Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends

Yuan, Kunshan; Deng, Chengchen; Tan, Lili; Wang, Xiangxiu; Yan, Wenhua; Dai, Xiaozhen; Du, Ruolin; Zheng, Yufeng; Zhang, Haijun; Wang, Guixue

doi:10.1016/j.bioactmat.2024.01.017

Cited by 2 publications

(1 citation statement)

References 170 publications

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“…Insufficient vascularization is still a great challenge in the regeneration of critical-sized bone tissue defects ( Takaoka et al, 2024 ; Yuan et al, 2024 ). The formation of the H-type vessel plays a key role in the progress.…”

Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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Global trend and hotspot of resin materials for dental caries repair: a bibliometric analysis

Han,

Wang

2024

Front. Mater.

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ObjectiveThe objective of this study is to explore the current research status, key areas, and future development trends in the field of resin materials for dental caries repair through an objective and quantitative analysis of the literature.MethodsA search was conducted on the Web of Science Core Collection using “dental cavity” and “resin” as keywords, covering the period from 2000 to 2023. Data including author names, journals, countries, institutions, keywords, and citation rates were extracted. The collected data was subjected to statistical analysis using bibliometrics methodology, and visual knowledge maps were generated using software like CiteSpace 6.2.R4, Microsoft365, and R.ResultsA total of 4800 articles were retrieved, involving 13,423 authors, 2654 institutions, 76 countries, and 560 journals. The number of publications and cumulative publications in this field showed an increasing trend, reaching a peak in 2022. Dental Materials was the journal with the highest number of publications, cumulative publications, and citation rates. XU HHK was the most prolific author in terms of publications and citations. The University of Maryland was the institution with the highest number of publications. Brazil was the country with the highest number of publications. The USA had the highest level of collaboration with other countries. Collaboration between different authors, institutions, and countries in this field was relatively close, which contributed to the rapid development of resin materials for caries repair. The current research focus is mainly on the nature of dental caries, characteristics of resin materials, and bonding strength of adhesives. Enhancing the bioactivity and remineralization of resin materials, advanced antibacterial strategies, longevity and durability of resin restorations, nanotechnology, and material innovation, as well as digital dentistry, will receive increased attention as future research trends.ConclusionResin materials for dental caries repair have received significant attention. Future research should combine nanotechnology and big data analysis to investigate the mechanisms of dental caries occurrence and development, enhance the performance and longevity of resin materials, and conduct high-quality, large-scale empirical research.

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Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends

Cited by 2 publications

References 170 publications

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Global trend and hotspot of resin materials for dental caries repair: a bibliometric analysis

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