Zinc gluconate supplementation impacts the clinical improvement in patients with ulcerative colitis

Moura, Mayara Storel Beserra de; Soares, Nina Rosa Mello; Barros, Susy Érika de Lima; Pinho, Flaviane Alves de; Silva, Tomas Magno Costa; Braz, Débora Cavalcante; Vieira, Edivan Carvalho; Lima, Murilo Moura; Parente, José Miguel Luz; Marreiro, Dilina do Nascimento; Silva, Adalberto Socorro da; Nogueira, Nadir do Nascimento

doi:10.1007/s10534-019-00225-0

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…We failed to find a significant association between Zn supplementation and the IL-2 production in the pooled estimate. However, sensitivity analysis revealed that Zn supplementation led to a significant increase in IL-2 level after omitting Beserra de Moura et al study (34) . The intervention groups in the mentioned (37) Thailand study were subjects with Zn deficiency in whom their serum Zn levels were not raised enough to reach Zn sufficiency status during the supplementation, likely because of short duration and low dosage of intervention.…”

Section: Discussionmentioning

confidence: 89%

“…On the other hand, another in vivo study reported that zinc gluconate and zinc sulphate had equivalent bioavailability (43) . The second cause is study population; in one study administered zinc gluconate, subjects had Zn deficiency (34) . It seems Zn supplementation had a more beneficial effect on inflammatory markers in the Zn deficiency status.…”

Section: Discussionmentioning

confidence: 99%

“…4(a)). However, sensitivity analysis revealed that removing Beserra de Moura et al study (34) in pooled analysis led to a significant increase in IL-2 level following Zn supplementation (SMD = 2•96 pg/ml; 95 % CI 2•03, 3•88; P < 0•05). Because of limited number of studies on IL-2, subgroup analysis and meta-regression were not possible.…”

Section: Effects Of Zinc On Il-2mentioning

confidence: 94%

“…Four of the included studies were performed in Iran (29)(30)(31)(32) . Other studies have been carried out in Turkey (33) , Brazil (34) , Russia (35) , Australia (36) , Thailand (37) , USA (38) South Korea (39) and Poland (40) with a total sample size of 680 (varied from 17 to 254 participants). The included studies were performed from 2010 to 2020.…”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

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Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

et al. 2021

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Chronic inflammation has been considered as the main cause of chronic diseases. Zn has anti-inflammatory effects by decreasing the expression of inflammatory markers. The present systematic review and meta-analysis study aims to evaluate the impact of Zn supplementation on inflammation. Pubmed (Medline), Scopus, Web of Science, and Embase databases were searched up to December 10th, 2020. Randomized placebo-controlled trials have investigated the effects of Zn supplementation on serum/plasma levels of inflammatory cytokines in >15 years’ subjects were included. A pooled meta-analysis was performed using a random-effect model. Sensitivity analysis was performed to determine the robustness of the observed effect sizes. Potential causes of heterogeneity were determined using subgroup analyses. The relationship between effect size and co-variables was explored using meta-regression. In the cases of the presence of publication bias, trim and fill analysis was carried out. Cochrane Collaboration’s tool was used for assessing the quality of the included studies. A total of 12 studies was included in meta-analysis. Zn could decrease IL-6 levels (SMD= -0.76 pg/ml; 95% CI: -1.28, -0.24; P= 0.004). There was no significant change in TNF-α (SMD= 0.42 pg/ml; 95% CI: -0.31, 1.16; P= 0.257) and IL-2 levels (SMD= 1.64 pg/ml; 95% CI: -1.31, 4.59; P= 0.277) following Zn supplementation. However, Zn could increase IL-2 significantly after deletion of one arm in sensitivity analysis (SMD= 2.96 pg/ml; 95% CI: 2.03, 3.88; P< 0.05). Conclusively, Zn supplementation can decrease the IL-6 level. Zn increased IL-2 level after sensitivity analysis. Zn supplementation has not ameliorative effects on TNF-α.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Effects Of Zinc On Il-2mentioning

confidence: 94%

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

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Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

et al. 2021

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“…Moreover, Jafari and Ghobadi suggested that we exclude a study by Beserra de Moura et al (7) , which is not randomized due to different plasma zinc status (deficient, sufficient) in intervention and control groups. Due to the limited number of studies, we included all controlled-clinical trial studies, regardless of being randomized or not; however, we mistakenly stated that the nonrandomized studies were excluded from our study.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Invited letter to editor in response to profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of randomised controlled trials

et al. 2021

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The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial

Khazdouz,

Daryani,

Cheraghpour

et al. 2023

Eur J Nutr

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Zinc gluconate supplementation impacts the clinical improvement in patients with ulcerative colitis

Cited by 12 publications

References 32 publications

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

Invited letter to editor in response to profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of randomised controlled trials

The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial

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