The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial

Khazdouz, Maryam; Daryani, Naser Ebrahimi; Cheraghpour, Makan; Alborzi, Foroogh; Hasani, Motahareh; Ghavami, Shaghayegh Baradaran; Shidfar, Farzad

doi:10.1007/s00394-023-03214-9

Cited by 3 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, only four studies [14,15,29,30] among those included in this systematic review analyzed cytokine levels, precluding the possibility of conducting a meta-analysis. The studies by [14,29] reported significant reductions in Interleukin-6 (IL-6) and Interferon gamma (IFN-γ) levels following supplementation with grounded flaxseed and riboflavin, respectively.…”

Section: Oxidative Stress and Inflammation Mediated By Cytokinesmentioning

confidence: 99%

Antioxidant Therapy in Inflammatory Bowel Disease: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials

Rodrigues Junior,

Vasconcelos,

Xavier

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

The objective of this study is to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review of clinical trials was conducted, searching electronic databases including PubMed, Science Direct, and Scopus. After excluding articles that did not meet the inclusion criteria, 19 studies were included in the systematic review and 8 in the meta-analysis (6 for antioxidant capacity, 6 for superoxide dismutase (SOD), and 5 for lipid peroxidation analyzed through malondialdehyde (MDA) levels). SOD was significantly modulated (RR = 0.3764, 95% CI [0.0262 to 0.7267], p = 0.035) but not antioxidant capacity (RR = 0.3424, 95% CI [0.0334 to 0.7183], p = 0.0742) or MDA (RR = −0.8534, 95% CI [−1.9333 to 0.2265], p = 0.1214). Nonetheless, studies investigating oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment are still scarce. This review highlights the potential of antioxidant supplementation in IBD management and underscores the need for further investigations into its effects on oxidative stress biomarkers and cytokines to improve therapeutic approaches for IBD patients.

show abstract

Section: Oxidative Stress and Inflammation Mediated By Cytokinesmentioning

confidence: 99%

Antioxidant Therapy in Inflammatory Bowel Disease: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials

Rodrigues Junior,

Vasconcelos,

Xavier

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

The Role of the Trace Element Selenium in Inflammatory Bowel Disease

Hu,

Xiao,

Fan

2024

Biol Trace Elem Res

View full text Add to dashboard Cite

The role of selenium in the pathogenesis and therapy of inflammatory bowel diseases

Glazunova,

Mameeva,

Samsonova

et al. 2024

HERALD of North-Western State Medical University named after I.

View full text Add to dashboard Cite

In recent decades, Russia, as well as around the world, has recorded a steady increase in the incidence of inflammatory bowel diseases, which include ulcerative colitis and Crohn’s disease. The incidence of inflammatory bowel diseases in Russia accounts for 4.1 per 100 thousand of the population for ulcerative colitis and 0.8 per 100 thousand – for Crohn’s disease. The prevalence of inflammatory bowel diseases in Russia is 19.3–29.8 cases per 100 thousand of the population for ulcerative colitis and 3.0–4.5 per 100 thousand – for Crohn’s disease. In recent years, selenium has attracted the attention of researchers due to its anti-inflammatory and antioxidant properties as well as its ability to influence the intestinal flora. There is evidence that inflammatory bowel diseases has deficiency of trace elements, which is more often detected during active period of the disease than during remission. The purpose of the review is to summarize and analyze current literature data on the relationship between selenium and inflammatory bowel diseases, with special emphasis on the mechanism and function of selenium in intestinal inflammation as well as to discuss the possible therapeutic use of selenium in inflammatory bowel diseases. The authors conducted a search for publications in the electronic databases PubMed and eLibrary. After the selection procedure, 87 studies were included in the review. Due to its anti-inflammatory and antioxidant properties, the concentration of selenium can be crucial in the occurrence and development of inflammatory bowel diseases. Dietary recommendations with the inclusion of selenium gradually improve the quality of life of patients with inflammatory bowel diseases. The development and use of selenium drugs have also provided new therapy strategies. In the future, a large number of experimental and clinical studies are still needed to confirm the relationship between selenium and inflammatory bowel diseases, which, in turn, will mark a new turn in the prevention and treatment of these severe chronic diseases.

show abstract

The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial

Cited by 3 publications

References 56 publications

Antioxidant Therapy in Inflammatory Bowel Disease: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials

Antioxidant Therapy in Inflammatory Bowel Disease: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials

The Role of the Trace Element Selenium in Inflammatory Bowel Disease

The role of selenium in the pathogenesis and therapy of inflammatory bowel diseases

Contact Info

Product

Resources

About