Zinc forms of faujasite zeolites as a drug delivery system for 6-mercaptopurine

Jakubowski, Marcel; Kucińska, Małgorzata; Ratajczak, Maria; Pokora, Monika; Murias, Marek; Voelkel, Adam; Sandomierski, Mariusz

doi:10.1016/j.micromeso.2022.112194

Cited by 24 publications

(27 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cytotoxicity studies were also carried out for the zinc zeolite described in this paper. The absence of zeolite toxicity was proven using MCF-7 cells [33]. is several times greater for Zn-X material than the number of other pores.…”

Section: Resultsmentioning

confidence: 98%

Zinc Zeolite as a Carrier for Tumor Targeted and pH-responsive Drug Delivery

Sandomierski

Jakubowski

Ratajczak

et al. 2023

J Inorg Organomet Polym

Self Cite

View full text Add to dashboard Cite

In this work, for the first time, a material was prepared that releases the drug in a controlled manner under the influence of the pH of cancer environment. The material is zinc zeolite, which only releases the drug at an acidic pH. The release of the drug in an acidic environment indicates a very high potential of the synthesized material in the treatment of cancer. This material does not release the drug at pH 7.4 even for more than 100 h which proves that healthy organs will not be affected. The advantage of this material over those previously described in the literature is that it releases the drug very quickly under the influence of the cancerous environment (88% of the drug during approx 2 h), as well as the fact that it does not release the drug in a different environment. Materials with both features have not been previously described, there are only works on materials having one of these features. Moreover, this material releases zinc ions which additionally act on cancer cells by inducing apoptosis of cancer cells by increasing the intracellular production of reactive oxygen species.

show abstract

Section: Resultsmentioning

confidence: 98%

Zinc Zeolite as a Carrier for Tumor Targeted and pH-responsive Drug Delivery

Sandomierski

Jakubowski

Ratajczak

et al. 2023

J Inorg Organomet Polym

Self Cite

View full text Add to dashboard Cite

show abstract

“…The nanogels were effectively uptaken by MCF-7 cells and induced the apoptosis of cancer cells. Additionally, Jakubowski et al developed zinc zeolite particles loaded with 6-MP, which demonstrated a significant improvement in anticancer efficacy compared to standard bolus 6-MP treatment [ 43 ]. This drug delivery system, based on particles, can effectively accumulate in tumor tissue through the enhanced permeability and retention effect and the binding of various targeting molecules.…”

Section: Resultsmentioning

confidence: 99%

Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment

Kim

Lee

Park

et al. 2023

Gels

View full text Add to dashboard Cite

Colon cancer is a significant health concern. The development of effective drug delivery systems is critical for improving treatment outcomes. In this study, we developed a drug delivery system for colon cancer treatment by embedding 6-mercaptopurine (6-MP), an anticancer drug, in a thiolated gelatin/polyethylene glycol diacrylate hydrogel (6MP-GPGel). The 6MP-GPGel continuously released 6-MP, the anticancer drug. The release rate of 6-MP was further accelerated in an acidic or glutathione environment that mimicked a tumor microenvironment. In addition, when pure 6-MP was used for treatment, cancer cells proliferated again from day 5, whereas a continuous supply of 6-MP from the 6MP-GPGel continuously suppressed the survival rate of cancer cells. In conclusion, our study demonstrates that embedding 6-MP in a hydrogel formulation can improve the efficacy of colon cancer treatment and may serve as a promising minimally invasive and localized drug delivery system for future development.

show abstract

“…Cytotoxicity studies were also carried out for zinc zeolites. The absence of zinc zeolite toxicity was proven using MCF-7 cells [ 15 ]. Additionally, their regular structure, which can be micro-and meso-, as well as macro-porous, and above all their ability to ion exchange, give promising prospects for using them for the controlled delivery of therapeutic agents to target sites in the human body [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…The absence of zinc zeolite toxicity was proven using MCF-7 cells [ 15 ]. Additionally, their regular structure, which can be micro-and meso-, as well as macro-porous, and above all their ability to ion exchange, give promising prospects for using them for the controlled delivery of therapeutic agents to target sites in the human body [ 15 , 16 ]. Zeolites containing calcium ions (divalent ions) in their structure are characterized by the ability to interact well with bisphosphonates (BP) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

et al. 2023

Self Cite

View full text Add to dashboard Cite

Osteoporosis is the most common metabolic disease of the skeletal system and is characterized by impaired bone strength. This translates into an increased risk of low-energy fractures, which means fractures caused by disproportionate force. This disease is quite insidious, its presence is usually detected only at an advanced stage, where treatment with pharmaceuticals does not produce sufficient results. It is obligatory to replace the weakened bone with an implant. For this reason, it is necessary to look at the possibilities of surface modification used in tissue engineering, which, in combination with the drugs for osteoporosis, i.e., bisphosphonates, may constitute a new and effective method for preventing the deterioration of the osteoporotic state. To achieve this purpose, titanium implants coated with magnesium or zinc zeolite were prepared. Both the sorption and release profiles differed depending on the type of ion in the zeolite structure. The successful release of risedronate from the materials at a low level was proven. It can be concluded that the proposed solution will allow the preparation of endoprostheses for patients with bone diseases such as osteoporosis.

show abstract

Zinc forms of faujasite zeolites as a drug delivery system for 6-mercaptopurine

Cited by 24 publications

References 50 publications

Zinc Zeolite as a Carrier for Tumor Targeted and pH-responsive Drug Delivery

Zinc Zeolite as a Carrier for Tumor Targeted and pH-responsive Drug Delivery

Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment

Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

Contact Info

Product

Resources

About