Zinc finger protein 91 accelerates tumour progression by activating β‐catenin signalling in pancreatic cancer

Tang, Neng; Xu, Shanshan; Song, Taiyu; Qiu, Yudong; He, Jian; Fu, Xiao

doi:10.1111/cpr.13031

Cited by 10 publications

(8 citation statements)

References 20 publications

(44 reference statements)

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“…The WNT/β-catenin pathway is one of the most crucial signaling pathways in modulating the occurrence of EMT in tumor cells (25)(26)(27). In addition, several studies were detected regarding the activation of WNT/β-catenin in PC (27)(28)(29)(30)(31). Combined with the EMT results of the present study, it was hypothesized that linc01614 may function as an oncogene partly by modulating the WNT/β-catenin signaling pathway.…”

Section: Linc01614 Promotes the Migration And Invasion Of Pc Cells In...supporting

confidence: 64%

Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β

Chen

Wang

et al. 2022

Int J Oncol

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Pancreatic cancer (PC) is a lethal type of cancer for which effective therapies are limited. Long non-coding RNAs (lncRNAs) represent a critical type of regulator category, mediating the tumorigenesis and development of various tumor types, including PC. However, the expression patterns and functions of numerous lncRNAs in PC remain poorly understood. In the present study, linc01614 was identified as a PC-related lncRNA. linc01614 was notably upregulated in PC tissues and cell lines and was associated with the poor disease-free survival of patients with PC according to the analysis of The Cancer Genome Atlas-derived datasets. Functionally, linc01614 knockdown suppressed PC cell proliferation, migration and invasion in vitro, and inhibited tumor proliferation in vitro and in vivo. Mechanistically, linc01614 overexpression stabilized the level of β-catenin protein to hyperactivate the WNT/β-catenin signaling pathway in PC cells. Further analyses revealed that linc01614 bound to GSK-3β and perturbed the interaction between GSK-3β and AXIN1, thereby preventing the formation of the β-catenin degradation complex and reducing the degradation of β-catenin. In summary, the present findings reveal that linc01614 may function as an oncogene and promote the progression of PC and may thus be considered as a potential therapeutic target in the future.

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Section: Linc01614 Promotes the Migration And Invasion Of Pc Cells In...supporting

confidence: 64%

Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β

Chen

Wang

et al. 2022

Int J Oncol

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“…For 'zinc-finger protein 91', an E3 ubiquitin ligase upregulated in prostate cancer, colon cancer and pancreatic cancer 24 , no experimental structures are available, but the human structure is predicted by AlphaFold (AF-Q05481). All transplanted zinc atoms have high global r.m.s.d.…”

Section: Zinc Binding Sitesmentioning

confidence: 99%

AlphaFill: enriching AlphaFold models with ligands and cofactors

et al. 2022

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Artificial intelligence-based protein structure prediction approaches have had a transformative effect on biomolecular sciences. The predicted protein models in the AlphaFold protein structure database, however, all lack coordinates for small molecules, essential for molecular structure or function: hemoglobin lacks bound heme; zinc-finger motifs lack zinc ions essential for structural integrity and metalloproteases lack metal ions needed for catalysis. Ligands important for biological function are absent too; no ADP or ATP is bound to any of the ATPases or kinases. Here we present AlphaFill, an algorithm that uses sequence and structure similarity to ‘transplant’ such ‘missing’ small molecules and ions from experimentally determined structures to predicted protein models. The algorithm was successfully validated against experimental structures. A total of 12,029,789 transplants were performed on 995,411 AlphaFold models and are available together with associated validation metrics in the alphafill.eu databank, a resource to help scientists make new hypotheses and design targeted experiments.

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“…ZFP91 promotes the proliferation, migration, and invasion of pancreatic cancer and enhances chemoresistance by activating the βcatenin signaling pathway. 89 ZEB1 is closely associated with the development of krasdriven PC, promotes EMT, and enhances the stemness and drug resistance. 90,91 In conclusion, majority of ZNFs can promote tumor cell proliferation, invasion, and migration in pancreatic cancer.…”

Section: Pancreatic Cancermentioning

confidence: 99%

“…Notably, some ZNFs may contribute to the chemoresistance. ZFP91 promotes the proliferation, migration, and invasion of pancreatic cancer and enhances chemoresistance by activating the β‐catenin signaling pathway 89 . ZEB1 is closely associated with the development of kras‐driven PC, promotes EMT, and enhances the stemness and drug resistance 90,91 .…”

Section: Role Of Znfs In Different Tumorsmentioning

confidence: 99%

The role of zinc finger proteins in malignant tumors

Zhao,

Wen,

Zhang

et al. 2023

The FASEB Journal

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Zinc finger proteins (ZNFs) are the largest family of transcriptional factors in mammalian cells. Recently, their role in the development, progression, and metastasis of malignant tumors via regulating gene transcription and translation processes has become evident. Besides, their possible involvement in drug resistance has also been found, indicating that ZNFs have the potential to become new biological markers and therapeutic targets. In this review, we summarize the oncogenic and suppressive roles of various ZNFs in malignant tumors, including lung, breast, liver, gastric, colorectal, pancreatic, and other cancers, highlighting their role as prognostic markers, and hopefully provide new ideas for the treatment of malignant tumors in the future.

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Zinc finger protein 91 accelerates tumour progression by activating β‐catenin signalling in pancreatic cancer

Cited by 10 publications

References 20 publications

Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β

Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β

AlphaFill: enriching AlphaFold models with ligands and cofactors

The role of zinc finger proteins in malignant tumors

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