Zinc-doping enhanced cadmium sulfide electrochemiluminescence behavior based on Au-Cu alloy nanocrystals quenching for insulin detection

Zhu, Wenjuan; Wang, Chao; Li, Xiaojian; Khan, Malik Saddam; Sun, Xu; Ma, Hongmin; Fan, Dawei; Wei, Qin

doi:10.1016/j.bios.2017.05.046

Cited by 51 publications

(16 citation statements)

References 43 publications

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“…Some available methods for CEA detection have been developed, such as fluorometry, amperometry, electrochemistry, and capillary electrophoresis . However, these analysis methods have some shortcomings, such as time-wasting, base-current interference, waste of materials, complicated instrumentation, etc. Electrochemiluminescence (ECL) is a light-emission phenomenon generated at an electrode through highly energetic electron-transfer reactions and implies the resulting combination of electrochemistry and chemiluminescence .…”

Section: Introductionmentioning

confidence: 99%

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce₂Sn₂O₇ Nanocubes

2021

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In this research article, a novel and simple label-free electrochemiluminescence (ECL) immunosensor using cerium stannite (Ce2Sn2O7) nanocubes as brand-new ECL emitters has been suggested for the first time. Ce2Sn2O7 nanocubes prepared by a simple hydrothermal method displayed bright ECL emission, promising biocompatibility, low noxiousness, and perfect stability. On comparison of ECL and photoluminescence (PL) spectra, a surface-state mechanism was proposed to be involved in the ECL emission. After aminofunctionalization with 3-aminopropyltriethoxysilane (APTES), Ce2Sn2O7 could be decorated with gold nanoparticles through Au–NH2 covalent linkage, which yielded Au@Ce2Sn2O7 nanocomposites and further enhanced the ECL emission. To confirm the proposed immunosensor feasibility, carcinoembryonic antigen (CEA) was employed as an exemplary analyte. Based on the abovementioned points, our fabricated immunosensor improved the ECL performance to CEA concentrations in a linear range of 0.001–70 ng/mL with a low limit of detection of 0.53 pg/mL (S/N = 3). With outstanding stability, reproducibility, and specificity, this method is expected to be an innovative one for sensitive analyses of CEA and other biomarkers in real samples.

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Section: Introductionmentioning

confidence: 99%

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce₂Sn₂O₇ Nanocubes

2021

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“…Moreover, Zhu et al [ 79 ] have also fabricated a sandwich-type ECL biosensor for detecting insulin based on the ECL property of zinc-doping cadmium sulfide (Au-ZnCd 14 S) ( Figure 3 B). Au-ZnCd 14 S combined nitrogen doping mesoporous carbons (Au-ZnCd 14 S/NH 2 -NMCs) acted as sensing platform and Au-Cu alloy nanocrystals were employed as labels to quench the ECL of Au-ZnCd 14 S/NH 2 NMCs.…”

Section: Metallic Sulfide Nanomaterialsmentioning

confidence: 99%

“… ( A ) Schematic diagram of the HIV gene biosensor using EuS nanocrystals as luminophore [ 70 ]. Reproduced with permission Copyright 2018, Elsevier B.V. ( B ) The fabrication of insulin biosensor based on Au-ZnCd 14 S [ 79 ]. Reproduced with permission Copyright 2017, Elsevier B.V. ( C ) Schematic fabrication process of ECL sensor and CE-ECL detection [ 80 ].…”

Section: Figures Scheme and Tablesmentioning

confidence: 99%

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Wang

Jiang

et al. 2020

Sensors

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In recent years, sulfur-containing nanomaterials and their derivatives/composites have attracted much attention because of their important role in the field of biosensor, biolabeling, drug delivery and diagnostic imaging technology, which inspires us to compile this review. To focus on the relationships between advanced biomaterials and biosensors, this review describes the applications of various types of sulfur-containing nanomaterials in biosensors. We bring two types of sulfur-containing nanomaterials including metallic sulfide nanomaterials and sulfur-containing quantum dots, to discuss and summarize the possibility and application as biosensors based on the sulfur-containing nanomaterials. Finally, future perspective and challenges of biosensors based on sulfur-containing nanomaterials are briefly rendered.

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“…Zhu et al [64] reported an efficient ECL resonance energy transfer (RET) system between ZnCd 14 S as a donor and Au-Cu alloy nanocrystals as an acceptor for highly sensitive and excellent specific detection of target insulin. ZnCd 14 S showed the stable and strong ECL emission in the presence of coreactant K 2 S 2 O 8 , which was enhanced by AuNPs and mesoporous carbons, and further quenched by Au-Cu alloy nanocrystals.…”

Section: Ecl Immunoassays/immunosensorsmentioning

confidence: 99%

Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals

Zhang

Yang

et al. 2019

Journal of Pharmaceutical Analysis

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Electrogenerated chemiluminescence (electrochemiluminescence, ECL) generates species at electrode surfaces, which undergoes electron-transfer reactions and forms excited states to emit light. It has become a very powerful analytical technique and has been widely used in such as clinical testing, biowarfare agent detection, and pharmaceutical analysis. This review focuses on the current trends of molecular recognition-based biosensing methods for pharmaceutical analysis since 2010. It introduces a background of ECL and presents the recent ECL developments in ECL immunoassay (ECLIA), immunosensors, enzyme-based biosensors, aptamer-based biosensors, and molecularly imprinted polymers (MIP)-based sensors. At last, the future perspective for these analytical methods is briefly discussed.

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Zinc-doping enhanced cadmium sulfide electrochemiluminescence behavior based on Au-Cu alloy nanocrystals quenching for insulin detection

Cited by 51 publications

References 43 publications

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce₂Sn₂O₇ Nanocubes

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce₂Sn₂O₇ Nanocubes

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals

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Zinc-doping enhanced cadmium sulfide electrochemiluminescence behavior based on Au-Cu alloy nanocrystals quenching for insulin detection

Cited by 51 publications

References 43 publications

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce2Sn2O7 Nanocubes

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce2Sn2O7 Nanocubes

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals

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Product

Resources

About

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce₂Sn₂O₇ Nanocubes

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce₂Sn₂O₇ Nanocubes