Zinc Deficiency

Sandstead, Harold H.

doi:10.1001/archpedi.1991.02160080029016

Cited by 190 publications

(38 citation statements)

References 78 publications

(6 reference statements)

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“…The classic features of Zn deficiency include retardation of growth in children, immunodeficiency, hypogeusia, loss of appetite, diarrhea, skin changes and delayed sexual maturation [4,24]. Zn is limiting in the diet of some indigenous peoples, including Australian aborigines, but severe primary Zn deficiency is relatively rare.…”

Section: Zinc Deficiencymentioning

confidence: 99%

“…The other aspect relevant to this issue is that having mild or sub-clinical Zn deficiency early in life (or in the fetus) may be a previously unrecognized risk factor for development of asthma. Infants and young children are especially vulnerable to Zn deficiency because of their higher Zn requirement for rapid growth [4,24,25]. Factors that might exacerbate this problem are the increasing trends towards Zn-poor diets based on processed foods and soy-based substitutes, as well as food grown on Zn poor soil.…”

Section: Local and Systemic Zinc Deficiencies In The Pathogenesis Of mentioning

confidence: 99%

“…The best indications of severe Zn deficiency are the presence of more than one of the following: growth retardation (in children), low plasma and hair Zn, persistent diarrhea, loss of taste acuity and poor wound healing [4]. Unfortunately, a single laboratory marker that also tests for mild Zn deficiency is not available.…”

Section: Monitoring Zn Deficiency In Subjects With Airway Inflammationmentioning

confidence: 99%

“…Much of the pioneer work on Zn metabolism occurred at least four decades ago, commencing with the initial studies of experimental Zn deficiency in rodents, the finding of stoichiometric quantities of Zn in carbonic anhydrase and other metalloproteins and, later, the identification of human Zn deficiency syndromes [1][2][3][4]. This was followed in the 1980s by discovery of the unique role of Zn in the function of Zn finger transcription factors [5].…”

Section: Introductionmentioning

confidence: 99%

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Zinc and its Specific Transporters as Potential Targets in Airway Disease

Murgia

Lang

Truong-Tran

et al. 2006

CDT

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The dietary group IIb metal zinc (Zn) plays essential housekeeping roles in cellular metabolism and gene expression. It regulates a number of cellular processes including mitosis, apoptosis, secretion and signal transduction as well as critical events in physiological processes as diverse as insulin release, T cell cytokine production, wound healing, vision and neurotransmission. Critical to these processes are the mechanisms that regulate Zn homeostasis in cells and tissues. The proteins that control Zn uptake and compartmentalization are rapidly being identified and characterized. Recently, the first images of sub-cellular pools of Zn in airway epithelium have been obtained. This review discusses what we currently know about Zn in the airways, both in the normal and inflamed states, and then considers how we might target Zn metabolism by developing strategies to monitor and manipulate airway Zn levels in airway disease.

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Section: Zinc Deficiencymentioning

confidence: 99%

Section: Local and Systemic Zinc Deficiencies In The Pathogenesis Of mentioning

confidence: 99%

Section: Monitoring Zn Deficiency In Subjects With Airway Inflammationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Zinc and its Specific Transporters as Potential Targets in Airway Disease

Murgia

Lang

Truong-Tran

et al. 2006

CDT

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“…Therefore, either a deficiency or excess of Zn 2+ is expected to be detrimental. In fact, 23% of the world's population has been estimated to be Zn 2+ deficient; this deficiency may cause illness such as pneumonia and diarrhea [7, 8]. Indispensable in maintaining membrane potential, especially in excitable cells, energy-dependent Na + /K + -pumps generate a 10 to 30-fold gradient for Na + and K + ions [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Zinc-Permeable Ion Channels: Effects on Intracellular Zinc Dynamics and Potential Physiological/Pathophysiological Significance

Inoue¹,

O’Bryant²,

Xiong³

2015

CMC

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Zinc (Zn2+) is one of the most important trace metals in the body. It is necessary for the normal function of a large number of proteins including enzymes and transcription factors. While extracellular fluid may contain up to micromolar Zn2+, intracellular Zn2+ concentration is generally maintained at a subnanomolar level; this steep gradient across the cell membrane is primarily attributable to Zn2+ extrusion by Zn2+ transporting systems. Interestingly, systematic investigation has revealed that activities, previously believed to be dependent on calcium (Ca2+), may be partially mediated by Zn2+. This is also supported by new findings that some Ca2+-permeable channels such as voltage-dependent calcium channels (VDCCs), N-methyl-D-aspartate receptors (NMDA), and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPA-Rs) are also permeable to Zn2+. Thus, the importance of Zn2+ in physiological and pathophysiological processes is now more widely appreciated. In this review, we describe Zn2+-permeable membrane molecules, especially Zn2+-permeable ion channels, in intracellular Zn2+dynamics and Zn2+ mediated physiology/pathophysiology.

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Zinc: Growth, development, and function

Sandstead

2000

J. Trace Elem. Exp. Med.

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Zinc Deficiency

Cited by 190 publications

References 78 publications

Zinc and its Specific Transporters as Potential Targets in Airway Disease

Zinc and its Specific Transporters as Potential Targets in Airway Disease

Zinc-Permeable Ion Channels: Effects on Intracellular Zinc Dynamics and Potential Physiological/Pathophysiological Significance

Zinc: Growth, development, and function

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