Zinc cross-linked hydroxamated alginates for pulsed drug release

Raut, Neha S.; Deshmukh, Prasad R; Umekar, Milind J.; Kotagale, Nandkishor R.

doi:10.4103/2230-973x.121292

Cited by 17 publications

(2 citation statements)

References 27 publications

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“…Kotagale et al [ 45 ] complexed alginates with zinc metal ion to improve beads' physicochemical and biological properties for controlling the drug release. They found that the atenolol-zinc polymeric beads exhibited pulsed release with increased half-life.…”

Section: Introductionmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

130

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Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.

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Section: Introductionmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

130

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“…1), a chiral polysaccharide, forms crosslinked hydrogels when complexed with suitable multivalent metal ions [26][27][28]. Subsequently, the ionotropic gelling technique evolves continuously and alginate becomes responsible for many drug-modified delivery systems as the resulted gel networks can confine small molecule drugs [29][30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

In vitro kinetic release study of ketoprofen enantiomers from alginate metal complexes

Alkhayer

Khudr²,

Koudsi

2021

Futur J Pharm Sci

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Background To explore the release behavior of ketoprofen enantiomers from alginate-metal-complexes. Five mathematical models of drug release kinetics were investigated. Results Beads of alginate-metal complexes, loaded with racemic ketoprofen, were prepared by the ionotropic method. Divalent (Ca, Ba, Zn) and trivalent (Fe, Al) metals were used in the preparation of single-metal and mixed-metal alginate complexes. In vitro release experiments were carried out in an aqueous phosphate buffer medium at pH = 7.4. The concentrations of ketoprofen released enantiomers were determined using chiral HPLC technique. The obtained data were used to simulate the release kinetic of ketoprofen enantiomers using various mathematical models. The Korsmeyer-Peppas model was the best fit for Ca, Al, and Fe beads. Moreover, alginate-iron beads tend to release the drug faster than all other cases. In contrast, the drug release for alginate-barium complex was the slowest. The presence of barium in alginate mixed-metal complexes reduced ketoprofen release in the case of Fe and Zn, while it increased the release in the case of Al complex. Conclusion In all the studied cases, ketoprofen showed very slow release for both enantiomers over a period exceeded 5 h (10 days in some cases). The release rate modification is possible using different multivalent metals, and it is also feasible by using two different metals for congealing either consecutively or simultaneously.

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Design and Optimization of pH‐Responsive Chitosan‐Coated Zn‐Carboxymethyl Cellulose Hydrogel Bead Carriers for Amoxicillin Trihydrate Delivery

Bulut

2022

ChemistrySelect

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In the study, chitosan (CS)‐coated carboxymethyl cellulose (CMC) bead carriers were developed via electrostatic interactions in the presence of chitosan and zinc ions, using amoxicillin trihydrate (AMX) as a model drug. The beads were produced by cross‐linking with Zn2+ ions by varying the drug/polymer ratio, concentration of chitosan and cross‐linker. Their structures were characterized with FTIR, XRD, TGA, DSC, and SEM. AMX release was investigated at two different pH mediums (1.2 and 7.4) at 37 °C. The release profiles of the carriers were highly affected by the degree of cross‐linking, the AMX/polymer ratio, pH, and especially the chitosan coating. As a result, the optimum AMX release was found as 77.4 % for chitosan‐coated beads (A3) with an AMX/polymer ratio of 1/5, ZnCl2 concentration of 1 %, CS concentration of 1 %. The entrapment efficiency for these carriers (A3) was found to be 57.61 % with high efficiency. It was also determined that AMX release was Fick diffusion and anomalous transport mechanism.

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Zinc cross-linked hydroxamated alginates for pulsed drug release

Cited by 17 publications

References 27 publications

Current Status of Alginate in Drug Delivery

Current Status of Alginate in Drug Delivery

In vitro kinetic release study of ketoprofen enantiomers from alginate metal complexes

Design and Optimization of pH‐Responsive Chitosan‐Coated Zn‐Carboxymethyl Cellulose Hydrogel Bead Carriers for Amoxicillin Trihydrate Delivery

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