Zinc coordination complexes as anticancer agents

Synthesis and crystal structures of new mixed-ligand schiff base complexes containing N-donor heterocyclic co-ligands: Molecular docking and pharmacophore modeling studies on the main proteases of SARS-CoV-2 virus (COVID-19 disease)

“…From the pharmacological point of view, they have shown antibacterial, antifungal, anti-inflammatory, antioxidant, anti-proliferative, etc. activity and numerous studies have been performed to develop efficient medicines with SB backbone [ [5] , [6] , [7] , [8] ]. Table 1.…”

Novel 5-fluorouracil complexes of Zn(ii) with pyridine-based ligands as potential anticancer agents

“…Two comprehensive reviews suggest that Zn(II) complexes may be considered as possible candidates for anticancer agents as an alternative to platinumbased anticancer drugs. 19,20 To the best of our knowledge, the crystal structure of a Zn(II) complex of 5-FU has not been reported in the literature. In this work, we report the syntheses, characterization and X-ray structures of five novel Zn(II) 5-FU complexes with a general formula of [Zn(5-FU) 2 (L)], where L is 2,2′-bipyridine (bpy), 1,10-phenanthroline ( phen), 2,2′-dipyridylamine (dpya), bis(2-pyridylmethyl)amine (bpyma) and 2,2′;6′,2″-terpyridine (terpy) in complexes 1-5, respectively (Scheme 1).…”

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

“…The presence of the benzimidazole molecule in bioactive compounds has an impact on antiparasitic, anticonvulsant, analgesic, antihistaminic, antiulcer, antihypertensive, antiviral, anticancer, antifungal and anti-inflammatory agents, and this compound has anticoagulant properties [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In this work, we focused on the design and creation of medically active coordination compounds containing a benzimidazole core, with potential anticancer properties and an element essential for all living organisms—zinc [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Currently, the leading cause of cancer-related mortality worldwide is lung cancer.…”