Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Abstract

Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named C1, C2, C4 and C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. The collected analytical data allowed the determination of the stoichiometry in coordination compounds, thermal stability, crystal structure and way of bonding. The cytotoxicity effect of the new compounds as a potential antitumor agent on the glioblastoma (T98G), neuroblastoma (SK-N-AS) and lung adenocarcinoma (A549) cell lines and human normal skin fibroblasts (CCD-1059Sk) was also determined. Cell viability was determined by the MTT assay. The results obtained confirmed that conversion of ligands into the respective metal complexes significantly improved their anticancer properties. The complexes were screened for antibacterial and antifungal activities. The ADME technique was used to determine the physicochemical and biological properties.

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

“…At the present time, there are very many studies of the substituted benzimidazole derivatives, which showed a distinctive activity to kill microbes or stop their growth, and that many of the prepared derivatives were efficacy comparable or superior to the standard drugs used for the same purpose [138]- [147] . [148]- [153] 4.7.…”

CLC-Pred 2.0: A Freely Available Web Application for In Silico Prediction of Human Cell Line Cytotoxicity and Molecular Mechanisms of Action for Druglike Compounds

“…It was based on the PASS Online approach [ 13 , 14 , 15 ] and the experimental data from ChEMBL’s 23 databases for 59,882 compounds. Since then, more than 80 papers have been published with studies using CLC-Pred to evaluate the cytotoxicity of new chemical compounds [ 16 , 17 ], natural compounds [ 18 , 19 , 20 ], as well as in studies aimed at finding new antitumor substances [ 21 , 22 ]. In the present paper, we offer a new version of the web application, CLC-Pred 2.0, that is based on significantly bigger data on the cytotoxicity of compounds in relation to cell lines.…”

Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of Pepper Plants

“…Minerals are unquestionably essential for plants to develop effectively [ 20 ]. The use of benzimidazole as a ligand for transition metal ions with a variety of biological molecules, including ion heme systems, vitamin B 12, and its derivatives, and various metal lipoproteins is very common [ 21 ].…”

“…The use of benzimidazole as a ligand for transition metal ions with a variety of biological molecules, including ion heme systems, vitamin B 12, and its derivatives, and various metal lipoproteins is very common [ 21 ]. Furthermore, the complexes of metal salts with benzimidazole derivatives have been extensively investigated as a model structure of numerous key biological molecules [ 20 ]. It has been reported previously that, occasionally, biologically relevant ligands are more active in metal complexes than in the free form [ 22 ].…”