Zinc and its role in vitamin D function

Amos, Ashton

doi:10.1016/j.crphys.2022.04.001

Cited by 14 publications

(23 citation statements)

References 65 publications

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“…Mineral ion deficiency in clinical medicine, including Ca 2+ , Mg 2+ , zinc (Zn 2+ ), and iron (Fe 3+ ), is more common than generally acknowledged in elderly individuals and disease-related malnutrition in hospitalized patients [ 68 , 69 , 70 , 71 , 72 , 73 ]. However, individuals with a higher phosphate burden are at a greater risk of developing complications associated with metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Phosphate Dysregulation and Metabolic Syndrome

2022

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Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual’s risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.

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Section: Discussionmentioning

confidence: 99%

Phosphate Dysregulation and Metabolic Syndrome

2022

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“…The body has 2–4 g of Zn, of which approximately 90% is located in the bones and muscles. Only 0.1% of the total Zn is present in plasma, where it is primarily bound to albumin, and in a very small quantity, bound to metallothionein and transferrin [ 35 , 36 , 37 ].…”

Section: Zincmentioning

confidence: 99%

Zinc, Magnesium and Vitamin K Supplementation in Vitamin D Deficiency: Pathophysiological Background and Implications for Clinical Practice

Bleizgys

2024

Nutrients

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Zinc, magnesium, and vitamin K are important nutrients for humans. There are various factors that contribute to the development of their deficiency, which might result in or exacerbate various diseases. These nutrients can also interact with vitamin D metabolism and activity. This review discusses the main aspects of zinc, magnesium and vitamin K metabolism and action in the body, their clinical significance, and the “crosstalk” with vitamin D, as well as providing general suggestions for clinical practice when supplementation with these nutrients might be useful, in addition to vitamin D supplementation.

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“…Nutritional imbalances, including in various vitamins and minerals, are associated with initiation and progression of numerous chronic disorders, including systemic and metabolic diseases (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Value-based nutritional care is an approach that links the incentive for healthcare providers to the value and outcomes they deliver to patients in terms of quality, equity, and cost of care.…”

Section: Editorial On the Research Topic Value-based Nutritional Inte...mentioning

confidence: 99%