Phosphate Dysregulation and Metabolic Syndrome

Mironov, Nikolay; Haque, Mainul; Atfi, Azeddine

doi:10.3390/nu14214477

Cited by 5 publications

(4 citation statements)

References 74 publications

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“…P is an important component of DNA and ATP, which mainly provides the energy for cell ( 33 ). P status imbalances often occur in neonates from clinically insignificant to those that can be life-threatening ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Changing trend of neonatal Ca/P/Mg status in a Chinese population

Mao,

Wu,

Shi

2023

Transl Pediatr

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Background Calcium (Ca), phosphorus (P), and magnesium (Mg) are essential elements for keeping the body homeostasis. We aimed to investigate the changing trend of serum levels of Ca/P/Mg in neonates. Methods We enrolled 82 premature newborns, 173 neonatal sepsis, 50 neonatal hypoglycemia, 254 neonatal jaundice, 43 neonatal haemolytic disease, and 59 healthy controls in our retrospective study. Serum levels of Ca/P/Mg were collected and expressed in quarters. We analysed the association between neonatal disorders and Ca/P/Mg levels (fourth quarter vs. first quarter) using binary logistic regression analysis. Smooth curve analysis was performed to analyze the non-linear association between birthweight/procalcitonin (PCT) and Ca/P levels. Threshold effect analysis was also performed to yield the turning point of birthweight/PCT in their associations with Ca/P levels. Results Binary logistic regression analyses showed that neonatal haemolytic disease, hypoglycemia, sepsis, jaundice, and prematurity were all significantly associated with the fourth quarter of Ca level (P<10 −4 ; P<10 −4 ; P<10 −4 ; P=0.001; and P<10 −4 , respectively). Neonatal hypoglycemia and prematurity were significantly associated with the fourth quarter of P level (P=0.004; and P=0.003, respectively). Neonatal haemolytic disease, hypoglycemia, sepsis, jaundice and prematurity were not associated with Mg level. Birthweight was significantly associated with Ca level before and after the turning point of 3,220 grams. PCT was significantly associated with Ca level before and after the turning point of 16.8 µg/L. Birthweight was significantly associated with P level before the turning point of 2,990 gram. PCT was significantly associated with P level before the turning points of 3.5 and 34.21 µg/L. Conclusions Neonatal disorders demonstrated a decreasing trend of serum Ca/P level. A significantly non-linear association was observed between birthweight/PCT and serum Ca/P levels.

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Section: Discussionmentioning

confidence: 99%

Changing trend of neonatal Ca/P/Mg status in a Chinese population

Mao,

Wu,

Shi

2023

Transl Pediatr

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“…Excessive dietary phosphorus intake has been linked to various health issues, including osteoporosis and cardiovascular diseases [14]. We speculate that elevated serum phosphorus due to excessive dietary intake may trigger inflammatory reactions and oxidative stress, negatively impacting the peripheral nervous system [15][16][17]. Additionally, phosphorus may influence the occurrence of PN by regulating the function of neuronal cell membranes and affecting neural signal transmission.…”

Section: Plos Onementioning

confidence: 99%

The relationship between dietary phosphorus and peripheral neuropathy in the general population of the United States: A preliminary research

Wu,

Chen

et al. 2024

PLoS ONE

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Background Dietary phosphorus intake may serve as a potential predictor for peripheral neuropathy (PN). While past research has predominantly focused on the relationship between dietary phosphorus and bone health, relatively little is known about its role in the nervous system, particularly its association with PN. Methods A cross-sectional study was conducted using data from NHANES 1999–2004. Participants were categorized into different dietary phosphorus intake groups, and the relationship between dietary phosphorus and PN was explored using multifactorial logistic regression, restricted cubic splines (RCS) analysis, and threshold effect analysis based on dietary intake. Results The final study included 7726 participants, with 1378 diagnosed with PN and 6348 without. The study revealed a U-shaped non-linear relationship between dietary calcium and magnesium intake levels and PN, indicating that both excessive and insufficient dietary phosphorus intake may increase the risk of PN. Specifically, the incidence rates in the first quintile (1.433, 95% CI: 1.080–1.901), the fourth quintile (1.284, 95% CI: 1.000–1.648), and the fifth quintile (1.533, 95% CI: 1.155–2.035) significantly higher than the second quintile, with an overall trend showing a decrease followed by an increase in incidence rates. The results of RCS and threshold effect analysis indicate that when dietary phosphorus intake is below 939.44mg, the risk of PN decreases with increasing dietary phosphorus intake. On the contrary, when dietary phosphorus intake exceeds 939.44mg, the risk of PN increases with increasing dietary phosphorus intake. Conclusion This study reveals a U-shaped correlation between dietary phosphorus intake and PN. Future research should further elucidate the molecular mechanisms underlying this association, providing guidance for more scientifically informed dietary adjustments to prevent the occurrence of PN.

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“…Nutritional imbalances, including in various vitamins and minerals, are associated with initiation and progression of numerous chronic disorders, including systemic and metabolic diseases (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Value-based nutritional care is an approach that links the incentive for healthcare providers to the value and outcomes they deliver to patients in terms of quality, equity, and cost of care.…”

Section: Editorial On the Research Topic Value-based Nutritional Inte...mentioning

confidence: 99%