Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia

Abstract

Objective: The aim of this study was to measure serum zinc-α2-glycoprotein (ZAG) in pregnant Egyptian females with preeclampsia and eclampsia and to correlate its levels to biochemical measures of kidney function, lipid and glucose metabolism. Study Design: It was a retrospective study. Patients and Methods:This study measured ZAG levels by enzyme linked immunosorbent assay (ELISA) in pregnant females with preeclampsia (PE) (no. = 40) and eclampsia (no.=20) and were compared to healthy gestational age-matched subjects (no.=20). In addition, the association of ZAG with kidney function, lipid and glucose metabolism was studied. Results: Significant difference was detected on comparing the different groups regarding ZAG levels (p = 0.001). Furthermore, ZAG was positively correlated to systolic blood pressure, urinary protein, fasting insulin and HOMA-IR. After adjusting for other parameters,the association between ZAG and SBP, urinary protein, serum insulin and HOMA-IR remained significant by multivariate linear regression analysis. Conclusion: The study noted that maternal ZAG serum levels are significantly increased in PE.