Zinc administration modulates radiation-induced oxidative injury in lens of rat

Taysı, Seyithan; Okumuş, Seydi; Akyüz, Mehmet; Uzun, Naim; Aksoy, Alper; Demir, Elif; Örkmez, Mustafa; Tarakçıoğlu, Mehmet; Adlı, Mustafa

doi:10.4103/0973-1296.103646

Cited by 24 publications

(10 citation statements)

References 25 publications

(34 reference statements)

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“…39 Moreover, the zinc has clear antioxidant properties and prevented oxidative stress by scavenging free radicals generated by ionizing radiation in rat lenses. 40 Taken together, further studies are needed to elucidate the precise mechanism for the accumulation and toxicity of Ab in the lenses of patients with cortical opacification. In addition, it is important to clarify the precise relationships of Ab and copper or zinc in the lens epithelium.…”

Section: Discussionmentioning

confidence: 99%

Amyloid β_1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Nagai

Mano

Otake

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.We investigated the accumulation of amyloid b (Ab 1-40 , Ab 1-42 , Ab ) in the lens epithelium of patients with opacification of five different types (cortical cataract [COR]; nuclear cataract [NUC]; posterior subcapsular cataract [PSC]; retrodots [RD]; and water clefts [WC]).METHODS. Samples were collected from Japanese patients taken during cataract surgery; Ab levels and mRNA expression were determined by ELISA and a real-time RT-PCR method, respectively.RESULTS. Levels of Ab 1-40 and Ab 1-42 in the lens epithelium of patients with COR, NUC, PSC, RD, and WC showed no significant differences in comparison with transparent lens epithelium. Levels of Ab 1-43 in the lens epithelium of patients with PSC and WC were not detected, and NUC and RD were slightly elevated. In contrast to the results in these cataract types, high Ab 1-43 levels were observed in the lens epithelium of patients with COR, and a close relationship was observed between Ab 1-43 levels and the degree of lens opacification (R ¼ 0.8229, n ¼ 6). The levels of Ab 1-43 were also higher in the lens epithelium of patients with mixed-cataract showing cortical opacification, and the Ab 1-43 levels in the lens epithelium of mixed-cataract patients with cortical opacification was significantly higher than in that of mixed-cataract patients without cortical opacification. In addition, the level of an amyloid precursor protein mRNA in the lens epithelium of mixed-cataract patients with cortical opacification was significantly higher than in transparent lens and mixed-cataract patients without cortical opacification. CONCLUSIONS.We found high levels of Ab 1-43 accumulation in the lens epithelium of Japanese patients with cortical opacification.Keywords: amyloid b, cortical cataract, human, lens epithelium, Japanese A ge-related cataracts are the most common cause of vision loss in the elderly, and the principal cause of blindness in the world. Age-related cataracts are classified by the location of the opacity within the lens: cortical cataracts (COR); nuclear cataracts (NUC); and posterior subcapsular cataracts (PSC). In addition, retrodots (RD) and water clefts (WC) have been found to be associated with visual impairment. Cataracts represent a complex disease with numerous genetic and environmental contributing factors, including smoking, ultraviolet irradiation, diabetes, the cumulative effect of X-rays, nutrition, vitamin C deficiency, hypertension, and alterations in both endocrine and enzymatic equilibria.1-8 On the other hand, it has recently been reported that the accumulation of amyloid b (Ab) peptides in the human lens may be related to the onset of lens opacification, 9-11 but this involvement in terms of etiology and Ab levels is not fully understood. 12 The enzymes a-secretase (a disintegrin and metalloproteinase, ADAM10) 13-15 ; b-secretase (b site APP cleaving enzyme, called BACE1) 16 ; and c-secretase (a presenilin complex, PS1 and PS2) 17 are known to be related to Ab production by cleaving an amyloid precursor protein (APP). The...

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Section: Discussionmentioning

confidence: 99%

Amyloid β_1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Nagai

Mano

Otake

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…H 2 O 2 interacts with metal ions to produce harmful hydroxyl free radical . Free radicals cause depletion of antioxidant molecules like GSH, which results in increased opacity of eye lens . SOD and GSH comprise inherent antioxidant defense system.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical characterization and evaluation of anticataract potential of seabuckthorn leaf extract

Dubey

Deep

Singh

2015

Veterinary Ophthalmology

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“…[ 7 8 ] Thus, various radiation intensities can result in cataract through crystal lens oxidation and ROS production,[ 9 ] but this injury in lens could be modulated by some substances such as zinc. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Radioprotective effect of hesperidin on reducing oxidative stress in the lens tissue of rats

Karimi

Monfared

Haddadi

et al. 2017

Int J Pharma Investig

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Introduction:Oxidative stress is a common factor in cataract. Considering the antioxidant properties of hesperidin as a flavanone glycoside from the flavonoid family with radioprotective effect, this study aimed to determine the protective effect of this flavanone glycoside on reducing oxidative stress in the eye lens tissue of mature rats caused by gamma irradiation.Materials and Methods:A total of 48 adult rats were randomly divided into six groups, namely, control, Dimethyl sulfoxide (DMSO), hesperidin, radiation, radiation + DMSO, and radiation + hesperidin. 15 Gy irradiation was carried out using Cobalt-60 teletherapy instrument with a source-to-surface distance of 80 cm at a dose rate of 98.5 cGy/min. 2 days following irradiation, we removed the rats' lenses and analyzed them to determine the effects of hesperidin.Results:The comparison of control and intervention groups after irradiation showed that malondialdehyde (MDA) level in the lens tissue was significantly higher in the irradiation groups than the control group. Furthermore, a significant difference between radiation and radiation + hesperidin groups were observed. The level of glutathione (GSH) in the lens tissue was significantly lower in the irradiation groups compared to the control group. Nonetheless, significant elevation of GSH in the radiation + hesperidin group compared to radiation group was seen.Conclusions:Radiation exposure reduced GSH and enhanced MDA levels in the lens tissue. However, GSH and MDA levels were modulated after hesperidin consumption. These results show the antioxidative properties of hesperidin in the lens and demonstrated that radiation complications such as cataract can be reduced by hesperidin through reducing oxidative stress.

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Zinc administration modulates radiation-induced oxidative injury in lens of rat

Cited by 24 publications

References 25 publications

Amyloid β_1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Amyloid β_1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Phytochemical characterization and evaluation of anticataract potential of seabuckthorn leaf extract

Radioprotective effect of hesperidin on reducing oxidative stress in the lens tissue of rats

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Zinc administration modulates radiation-induced oxidative injury in lens of rat

Cited by 24 publications

References 25 publications

Amyloid β1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Amyloid β1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Phytochemical characterization and evaluation of anticataract potential of seabuckthorn leaf extract

Radioprotective effect of hesperidin on reducing oxidative stress in the lens tissue of rats

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Amyloid β_1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients

Amyloid β_1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients