Zinc-65 retention by aortic tissue of rats

Strain, William H.; Huegin, Felix; Lankau, Charles A.; Berliner, W.P.; McEvoy, Richard K.; Pories, Walter J.

doi:10.1016/0020-708x(64)90069-9

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…It would seem, then, that the protective agents are exerting their counteractive effects at the vascular level. There is considerable evidence that zinc (Strain, 1961;Savlov, Strain & Huegin, 1962;Strain, Huegin, Lankau, Berliner, McEvoy & Pories, 1964), thiols (Bennett, 1951;Danielli, Danielli & Mitchell, 1947;Zweifach, 1961), selenium (Dam & Glavind, 1940;Rosenfeld & Beath, 1964) and cadmium (Schroeder, 1965;Carroll, 1966) are associated with vascularity or with cir¬ culatory disorders.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Zinc, Cysteine and Selenium Protection Against Cadmium-Induced Vascular Injury to Mouse Testis

Gunn¹,

Gould²,

Anderson³

1968

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It is known that the selective injurious effect of cadmium on the testis can be prevented by zinc, cysteine or selenium. Studies, conducted in CD-1 mice, were initiated to determine whether any of these treatments offered protection by preventing cadmium from reaching the testis in doses sufficient to cause injury. Using cadmium chloride, labelled with 109Cd, it was shown that none of these protective agents decreased the amount of cadmium reaching the testis. Zinc acetate evoked no significant changes, cysteine brought about a slight enhancement of cadmium level but selenium dioxide produced a marked and prolonged elevation of cadmium uptake by the testis. Comparable studies in which selenium, rather than cadmium, was labelled (75Se) demonstrated that, in the presence of cadmium, selenium levels were augmented. Possible mechanisms are discussed to explain the diverse means of protection offered by zinc, cysteine and selenium. Since the site of cadmium-induced testicular injury has been pinpointed at its vasculature, it is suggested that these protective agents exert their action at the vascular level.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Zinc, Cysteine and Selenium Protection Against Cadmium-Induced Vascular Injury to Mouse Testis

Gunn¹,

Gould²,

Anderson³

1968

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show abstract

“…1970, Magno, Baratta and Leonard 1966, Moeller, Baratta and Leonard 1964, Popov, Plotko, Ibatullin and Ramzaev 1967, Strain, Berliner, Lankau, McEvoy, Pories and Greenlow 1964, Strain, Berliner, Tangeman, Lankau and Pories 1965, Strain, Huegin, Lankau, Berliner, McEvoy and Pories 1964 . In using the hair for this purpose there are several essential advantages .…”

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confidence: 99%