Zinc 65 metabolism: gastrointestinal secretion by the pig

Jc, Pekas

doi:10.1152/ajplegacy.1966.211.2.407

Cited by 50 publications

(13 citation statements)

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“…ZnO therefore, has been used as a growth‐promoting feed additive besides its well‐known use as an active anti‐bacterial agent in a number of pharmaceuticals for skin disorders (Sawai ). However, the high level of dietary ZnO, which is mostly excreted into the feces unabsorbed (Pekas ; Hill ), poses substantial concerns regarding environmental pollution. European feed legislation therefore limits total dietary Zn in complete feed to a maximum of 150 ppm and sooner or later similar legislation may be adopted by non‐European countries as well.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation of lipid‐encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenicEscherichia coli

Kwon

Lee

Han

et al. 2014

Animal Science Journal

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This study was aimed to evaluate the effect of dietary supplementation of lipid-encapsulated (coated) zinc oxide ZnO on post-weaning diarrhea (colibacillosis) in weaned piglets challenged with enterotoxigenic Escherichia coli (ETEC). Thirty-two 35-day-old weaned piglets were orally challenged with 3 × 10(10) colony forming units of ETEC K88 while eight piglets received no challenge (control). Each eight challenged piglets received a diet containing 100 ppm ZnO (low ZnO), 2500 ppm ZnO (high ZnO) or 100 ppm of lipid (10%)-coated ZnO (coated ZnO) for 7 days; control pigs received the low ZnO diet. Daily gain, goblet cell density in the villi of the duodenum, jejunum and ileum, and villus height in the jejunum and ileum, which decreased due to the challenge, were equally greater in the coated ZnO and high ZnO groups versus low ZnO group. Fecal consistency score, serum interleukin-8 concentration, subjective score of fecal E. coli shedding, and digesta pH in the stomach, jejunum and ileum, which increased due to the challenge, were equally low in the coated ZnO and high ZnO groups versus low ZnO. Results suggest that a low level of coated ZnO might well substitute for a pharmacological level of native ZnO in dietary supplementation to alleviate colibacillosis of weaned piglets.

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Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation of lipid‐encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenicEscherichia coli

Kwon

Lee

Han

et al. 2014

Animal Science Journal

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“…In health, the physiologic mechanisms vary with each individual trace element. Zinc is excreted primarily in pancreatic secretions (38,39); iron is excreted as a component of the desquamation of intestinal cells (35) and can also be wasted as a consequence of occult hemorrhage; and copper is excreted from the liver into the gut via the bile in a form that is not readily reabsorbed (40,41). The excretion of both sodium and potassium is largely controlled by renal mechanisms under normal conditions of health, and only with diarrheal or emetic processes can the gastrointestinal loss of electrolytes exceed that of the kidneys.…”

Section: Discussionmentioning

confidence: 99%

Mineral Excretion during Acute, Dehydrating Diarrhea Treated with Oral Rehydration Therapy

Ruz

Solomons

1990

Pediatr Res

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ABSTRACT. Twenty-four male Guatemalan children, aged 7 to 23 mo, suffering dehydration due to acute diarrhea were studied to assess their fecal endogenous losses of trace minerals zinc, iron, and copper while treated with oral rehydration therapy, either with standard or glycineadded solutions. Sodium and potassium excretions (from endogenous and exogenous sources) were also monitored. No statistically significant effect of glycine was observed on any of the minerals studied, although a tendency to higher output was seen with zinc. Median rates of fecal excretion of zinc, iron, and copper were 6.08, 6.33, and 1.61 pg/kg/h, respectively, whereas those for sodium and potassium were 11.2 and 9.

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“…Specifically, for the weight used, recommendations for meeting the nutritional requirements proposed by Rostagno et al (2011) are about 90 mg kg -1 of Zn. After the metabolism of this element in the animal, its excretion occurs mainly via feces (PEKAS, 1966) and can be disseminated in the soil via organic fertilization (GIROTTO et al, 2010). In toxic concentrations, Zn can damage soil fauna, because its retention occurs mainly in soil organic matter particles (ASHWORTH; ALLOWAY, 2004).…”

Section: Avoidance Behavior Of Springtailsmentioning

confidence: 99%

Different diets with and without inclusion of antimicrobial additives alter the toxicity of swine manure to springtails and earthworms

et al. 2020

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The objective of this study was to measure the impact on part of soil fauna of application of non-stabilized (fresh) manure from post-weaning pigs fed diets formulated with or without dual-purpose wheat, and with or without the use of antimicrobial growth-promoting additives (100 mg kg-1 doxycycline + 50 mg kg-1 colistin + 250 mg kg-1 Zn oxide). Two species of edaphic organisms were evaluated, the springtails Folsomia candida and the earthworms Eisenia andrei, using ecotoxicological avoidance behavior tests. The treatments were swine manure from: RR: Reference Ration; WR: Wheat Reference; RA: Reference Ration + Antimicrobial Additives; WA: Wheat Reference + Antimicrobial Additives). The doses of waste used for treatments were as follows: 0, 5, 10, 20, 30, 40, 65 and 100 m³ ha-1 for the springtails and 0, 5, 10, 20, 30, 40 and 65 m³ ha-1 for the earthworms, applied in the Oxisol. The experimental design was completely randomized with five replicates. The use of non-stabilized swine manure did not affect the avoidance behavior of F. candida at any dose, regardless of the use of antimicrobial or wheat additives. For E. andrei, there was avoidance behavior at all treatments and doses used. These avoidance behaviors were related to the sensitivity of each species of soil organism. The avoidance behavior for earthworms was related to the doses of non-stabilized swine manure in soil and not to the various diets and/or the use of growth-promoting additives.

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Zinc 65 metabolism: gastrointestinal secretion by the pig

Cited by 50 publications

References 0 publications

Effects of dietary supplementation of lipid‐encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenicEscherichia coli

Effects of dietary supplementation of lipid‐encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenicEscherichia coli

Mineral Excretion during Acute, Dehydrating Diarrhea Treated with Oral Rehydration Therapy

Different diets with and without inclusion of antimicrobial additives alter the toxicity of swine manure to springtails and earthworms

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