Zika Virus Serene Protease Complex (Ns2b-Ns3) Inhibition by 2-Amino-5-{[(1z)-Amino({[(z)-Benzoyl]imino})methyl]amino}-N-(5-Amino-7-{[Carbamoyl(phenyl)methyl]amino}-6-Oxoheptyl)pentanamide, in Silico Studies

Drug discovery and design is a tedious and lengthy process which takes enormous time, andwhen this process reaches it’s final stage that is the final stage of clinical trials 90% of thepromising drug candidates fail levying a huge financial burden of around $2-3bn on thedeveloper company. The drug failure not only incurs a financial loss to the company, but alsosmashes the hopes of the patients and families waiting for the successful approval of the drug.The scenario is even complicated when it comes to the drug approval for diseases likeAlzheimer’s. Computer aided drug design may help in the drug discovery process by slashingthe time required for searching the potential drug target through computer aided software andprograms. However the key to the success of the drug still lies in the understanding of themechanism of the cause of disease and prognosis. Computer aided drug design help in theselection and modification of leads out of number of hits available. The present study dealswith a case study of Intepridine an ambitious Axovant drug molecule which failed in the finalphase of clinical trials and was withdrawn from the market by Axovant the developer pharmacompany.

show abstract

Computer Aided Drug Design: A Paradigm Shift to Rational Drug Design (A Case Study of Alzheimer’s Drug Interpirdine Failure)

Singh¹,

Shouche²,

Merugu

et al. 2020

Int. J. Eng. Tech. Mgmt. Res.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Zika Virus Serene Protease Complex (Ns2b-Ns3) Inhibition by 2-Amino-5-{[(1z)-Amino({[(z)-Benzoyl]imino})methyl]amino}-N-(5-Amino-7-{[Carbamoyl(phenyl)methyl]amino}-6-Oxoheptyl)pentanamide, in Silico Studies

Cited by 1 publication

References 32 publications

Computer Aided Drug Design: A Paradigm Shift to Rational Drug Design (A Case Study of Alzheimer’s Drug Interpirdine Failure)

Computer Aided Drug Design: A Paradigm Shift to Rational Drug Design (A Case Study of Alzheimer’s Drug Interpirdine Failure)

Contact Info

Product

Resources

About