2016
DOI: 10.1371/journal.pntd.0004530
|View full text |Cite
|
Sign up to set email alerts
|

Zika Virus: Medical Countermeasure Development Challenges

Abstract: IntroductionReports of high rates of primary microcephaly and Guillain–Barré syndrome associated with Zika virus infection in French Polynesia and Brazil have raised concerns that the virus circulating in these regions is a rapidly developing neuropathic, teratogenic, emerging infectious public health threat. There are no licensed medical countermeasures (vaccines, therapies or preventive drugs) available for Zika virus infection and disease. The Pan American Health Organization (PAHO) predicts that Zika virus… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
158
0
7

Year Published

2016
2016
2018
2018

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 174 publications
(166 citation statements)
references
References 93 publications
(114 reference statements)
1
158
0
7
Order By: Relevance
“…Zika virus was first isolated from the serum of rhesus monkey in 1947 from the Zika forest of Uganda [1,2,6] ; simultaneously it has been spread to different places in the world. It was first identified in human in 1952 in Uganda and Tanzania [1] .…”
Section: Epidemiologymentioning
confidence: 99%
See 2 more Smart Citations
“…Zika virus was first isolated from the serum of rhesus monkey in 1947 from the Zika forest of Uganda [1,2,6] ; simultaneously it has been spread to different places in the world. It was first identified in human in 1952 in Uganda and Tanzania [1] .…”
Section: Epidemiologymentioning
confidence: 99%
“…The Flavivirus covers so many viral species such as yellow fever, dengue, Saint Louis encephalitis and West Nile viruses etc [17] . The Zika virus is spread by Aedes mosquito mainly Aedesaegypti and Aedesalbopictus particularly in the day time because this virus is very much active in day time [1,2,3,5] . This virus is enveloped, icosahedral and has a non-segmented single stranded positive RNA genome [8] .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The rapid development of a safe and effective ZIKV vaccine is a global health priority [1], [2], but very little is currently known about ZIKV immunology and mechanisms of immune protection. [7] was able to show that a single immunization of a plasmid DNA vaccine or a purified inactivated virus vaccine provides complete protection in susceptible mice against ZIKV strain from northeast Brazil.…”
Section: Introductionmentioning
confidence: 99%
“…The ZV has also raised attention to the possible deleterious effects that it may have on foetuses [12]. However, ''there are no licensed medical counter measures (vaccines, therapies or preventive drugs) available for Zika virus infection and disease'' [8]. In such a situation, studies on ZV are centric to the scientific interests.…”
mentioning
confidence: 99%