Zika virus infection–associated acute transient polyneuritis

Nascimento, Osvaldo J. M.; Frontera, Jennifer A.; Amitrano, Daniel A.; Filippis, Ana María Bispo de; Silva, Ivan R.F. da

doi:10.1212/wnl.0000000000004026

Cited by 18 publications

(11 citation statements)

References 7 publications

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“…During Zika viremia a mild illness can develop with symptoms such as fever, nonpurulent conjunctivitis, a maculopauplar rash, arthritis/arthralgias, headache, and vomiting (Petersen et al, ). Neurological disorders associated to ZIKV disease include now Guillain–Barré Syndrome, meningoencephalitis, myelitis, ophthalmic manifestations, and acute transient polyneuritis (Nascimento et al, ). There are four genetically distinct serotypes of DENV (DENV‐1, DENV‐2, DENV‐3, and DENV‐4).…”

Section: Introductionmentioning

confidence: 99%

Synergistic terpene combinations as larvicides against the dengue vector Aedes aegypti Linn.

Dhinakaran

Mathew

Munusamy

2019

Drug Development Research

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Most of the essential oils (EO) known for mosquitocidal activity contain terpenes as part of their chemical constituents. In this study, four monoterpenes namely γ‐terpinene (T), R‐(+)‐limonene (L), carvacrol (C), and trans‐anethole (A) were screened against late third instar Aedes aegypti Linn. larvae singly and in combination to find out the synergistic interaction. The monoterpenes γ‐terpinene, R‐(+)‐limonene, trans‐anethole, and carvacrol showed larvicidal activity with LC50 values of 9.76, 11.88, 50.19, 48.57 ppm and LC90 values of 16.99, 17.78, 65.21, 75.02 ppm, respectively for Ae. aegypti when tested individually. Prepared binary combinations at LC20 values and studied the synergistic interactions based on cotoxicity factor (CTF) and found that all the binary combinations showed synergistic interactions (CTF > 20). Further, the binary (1:1), ternary (1:1:1), and quaternary (1:1:1:1) terpene combinations on equal weight basis were prepared, evaluated against Ae. aegypti larvae and synergistic interactions were studied by Wadley's method. Among the eight combinations two combinations viz. LC (LC5010.42 ppm) and LA (LC5011.86 ppm) were showing synergistic interactions (R > 1.5) and others were exhibiting additive effect (1.5 ≥ R > 0.5) and none of the combinations showed antagonism (R < 0.5). Among the two methods used the Wadley's method found suitable when combinations were made on an equal weight basis. The two binary combinations found in this study are promising synergistic mixtures which has scope in designing mosquito larvicidal EOs by enriching the EOs with terpenes or by producing EO combinations with these terpenes as chemical constituents in the correct proportions.

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Section: Introductionmentioning

confidence: 99%

Synergistic terpene combinations as larvicides against the dengue vector Aedes aegypti Linn.

Dhinakaran

Mathew

Munusamy

2019

Drug Development Research

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“…In 2015–2016, ZIKV infected individuals in South America, first in Northeast Brazil, rapidly disseminating to other South American, Caribbean and Central America countries, and reached North America by the end of 2016, with a parallel increase in cases of Guillain–Barré Syndrome (GBS) (2). Neurological disorders associated to ZIKV disease include now GBS, meningoencephalitis, myelitis, ophthalmic manifestations, and acute transient polyneuritis (3).…”

Section: Introductionmentioning

confidence: 99%

Guillain–Barré Syndrome Associated With Zika Virus Infection: A Prospective Case Series From Mexico

Soto-Hernández

Rosales²,

Cañas

et al. 2019

Front. Neurol.

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Background: On May 2016, anticipating the rainy season from June to October in Mexico, we expected an increase in cases of Zika virus (ZIKV) infections. With the goal of identifying cases of GBS associated with ZIKV infection, a prospective joint study was conducted by a reference center for neurological patients and the Secretary of Health in Mexico City from July 2016 to November 2016. Methods: Serum, cerebrospinal fluid, urine, and saliva were tested by RT-PCR for ZIKV, dengue virus, and chikungunya virus in patients referred from states with reported transmissions of ZIKV infection, and with clinical symptoms of GBS according to the Brighton Collaboration criteria. Clinical, electrophysiological, and long-term disability data were collected. Results: In the year 2016 twenty-eight patients with GBS were diagnosed at our institute. In five hospitalized patients with GBS, RT-PCR was positive to ZIKV in any collected specimen. Dengue and chikungunya RT-PCR results were negative. All five patients had areflexic flaccid weakness, and cranial nerves affected in three. Electrophysiological patterns were demyelinating in two patients and axonal in three. Three patients were discharged improved in 10 days or less, and two patients required intensive care unit admission, and completely recovered during follow-up. Conclusion: Our results are similar to those reported from the state of Veracruz, Mexico, in which out of 33 samples of urine of patients with GBS two had a positive RT-PCR for ZIKV. Simultaneous processing of serum, CSF, urine, and saliva by RT-PCR may increase the success of diagnosis of GBS associated to ZIKV.

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“…There have been sporadic case reports linking other peripheral nerve and neuromuscular diseases to ZIKV infection, including two cases with acute onset of chronic inflammatory demyelinating polyneuropathy (CIDP), three cases of transient polyneuritis and two cases of myasthenia gravis. 24–26 The patients with transient polyneuritis had mild distal sensory and motor symptoms that resolved within 10 days and a positive PCR test for ZIKV in serum and CSF, suggesting a self-limiting direct peripheral nerve infection by ZIKV.…”

Section: Neurological Complications Of Zikv In the Adultmentioning

confidence: 90%

Zika virus infection in the returning traveller: what every neurologist should know

et al. 2018

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Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers with Zika virus infection have been reported and the virus continues to spread to previously unaffected regions. This review provides an overview of Zika virus-associated neurological disease and aims to support neurologists who may encounter patients returning from endemic areas.

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Zika virus infection–associated acute transient polyneuritis

Cited by 18 publications

References 7 publications

Synergistic terpene combinations as larvicides against the dengue vector Aedes aegypti Linn.

Synergistic terpene combinations as larvicides against the dengue vector Aedes aegypti Linn.

Guillain–Barré Syndrome Associated With Zika Virus Infection: A Prospective Case Series From Mexico

Zika virus infection in the returning traveller: what every neurologist should know

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