Zika Virus Genital Tract Shedding in Infected Women of Childbearing age: Table 1.

Prisant, Nadia; Breurec, Sébastien; Morinière, Catherine; Bujan, Louis; Joguet, Guillaume

doi:10.1093/cid/ciw669

Cited by 28 publications

(20 citation statements)

References 6 publications

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“…This is critical because virus-harboring blood monocytes could serve as a reservoir for latent ZIKV infection and for dissemination of ZIKV into other parts of the body, even though there is no evidence for this at this time. In recent studies performed in ZIKV-infected women of childbearing age, ZIKV RNA was detected in both vaginal secretions [ 23 , 30 ] and blood [ 23 ]. Likewise, in men, ZIKV has been reported to persist in semen for extended periods [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

A Sensitive Method for Detecting Zika Virus Antigen in Patients’ Whole-Blood Specimens as an Alternative Diagnostic Approach

Lum

Lin

Susova

et al. 2017

The Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

A Sensitive Method for Detecting Zika Virus Antigen in Patients’ Whole-Blood Specimens as an Alternative Diagnostic Approach

Lum

Lin

Susova

et al. 2017

The Journal of Infectious Diseases

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“…ZIKV is transmitted by at least three species of Aedes mosquitoes [ 2 , 6 , 7 ], but unlike other neurotropic flaviviruses, ZIKV is also transmitted sexually [ 8 , 9 ]. Following ZIKV infection, the virus is shed in urine and semen for several months and has also been detected in vaginal secretions [ 10 , 11 , 12 ]. Although ZIKV infection of testes has been demonstrated in animal models [ 13 , 14 , 15 , 16 ], viral RNA was also present in seminal fluid in vasectomized mice, suggesting that prolonged ZIKV shedding in semen may originate from a persistent site of infection other than the testes [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Zika Virus Persistently and Productively Infects Primary Adult Sensory Neurons In Vitro

et al. 2017

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Zika virus (ZIKV) has recently surged in human populations, causing an increase in congenital and Guillain-Barré syndromes. While sexual transmission and presence of ZIKV in urine, semen, vaginal secretions, and saliva have been established, the origin of persistent virus shedding into biological secretions is not clear. Using a primary adult murine neuronal culture model, we have determined that ZIKV persistently and productively infects sensory neurons of the trigeminal and dorsal root ganglia, which innervate glands and mucosa of the face and the genitourinary tract, respectively, without apparent injury. Autonomic neurons that innervate these regions are not permissive for infection. However, productive ZIKV infection of satellite glial cells that surround and support sensory and autonomic neurons in peripheral ganglia results in their destruction. Persistent infection of sensory neurons, without affecting their viability, provides a potential reservoir for viral shedding in biological secretions for extended periods of time after infection. Furthermore, viral destruction of satellite glial cells may contribute to the development of Guillain-Barré Syndrome via an alternative mechanism to the established autoimmune response.

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“…This hypothesis has been strengthened by numerous reports showing the long-term detection of ZIKV RNA and the isolation of infectious ZIKV from semen (Musso et al, 2015;Matheron et al, 2016;Nicastri et al, 2016;Moreira et al, 2017). ZIKV RNA has also been detected in female genital tract samples beyond viremia, albeit more transiently than in semen: it became undetectable around 3 weeks after symptom onset (Prisant et al, 2016(Prisant et al, , 2017Murray et al, 2017). Moreover, Penot et al (2017) have isolated infectious ZIKV from vaginal samples collected 3 days after the onset of symptoms from a woman with controlled HIV infection.…”

Section: Non-vectorial Transmissionmentioning

confidence: 94%

Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

2018

Frontiers Research Topics

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Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.

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Zika Virus Genital Tract Shedding in Infected Women of Childbearing age: Table 1.

Cited by 28 publications

References 6 publications

A Sensitive Method for Detecting Zika Virus Antigen in Patients’ Whole-Blood Specimens as an Alternative Diagnostic Approach

A Sensitive Method for Detecting Zika Virus Antigen in Patients’ Whole-Blood Specimens as an Alternative Diagnostic Approach

Zika Virus Persistently and Productively Infects Primary Adult Sensory Neurons In Vitro

Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

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