Zika virus: epidemiology, clinical aspects, diagnosis, and control of infection

Karkhah, Ahmad; Nouri, Hamid Reza; Javanian, Mostafa; Koppolu, Veerendra; Masrour-Roudsari, Jila; Kazemi, Sohrab; Ebrahimpour, Soheil

doi:10.1007/s10096-018-3354-z

Cited by 24 publications

(15 citation statements)

References 107 publications

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“…In addition, Zika virus (ZIKV), one of the emerging viruses in the world, is a member of the virus family Flaviviridae 46 . Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range and threatens to devastate the population 47 . Myhrvold et al reported a specific and sensitive method for in vitro diagnosis of the dengue virus (DENV) and ZIKV, directly 41 .…”

Section: Crispr/cas–based In Vitro Diagnosticsmentioning

confidence: 99%

CRISPR‐Cas system for biomedical diagnostic platforms

Wang

Cui

2020

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Clustered short palindrome repeats with regular intervals, abbreviated as CRISPR, and functions as a self‐defense system for prokaryotes, detecting particular pathogenic nucleic acid, interfering with the functions of exoteric DNA, and protecting them against foreign invaders. In recent years, CRISPR has attracted increasing interests in the in vitro diagnostic field because of its inherent allele specificity, which is one of the critical factors for the successful application of this technology in the development of high‐precision treatment and diagnosis. Herein, this review article aims to provide an overview of CRISPR‐CRISPR associated proteins (Cas) based biomedical diagnostics, including the biological mechanism, biomaterials, and applications. This paper first briefly introduces the development history and biological characteristics of the CRISPR‐Cas system, and then summarizes the application status and development trend of the CRISPR‐Cas system in the detection and identification of particular pathogens, specifically displaying a brilliant prospect in the most recent outbreak of novel coronavirus (formerly named 2019‐nCoV). Moreover, its potential diagnostic power in oncogene mutations and single nucleotide variations detecting are assembled. Finally, we discuss challenges and future prospects of CRISPR‐Cas system based diagnostic platforms in biomedicine, hoping to further inspire the development of biomedical diagnostics.

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Section: Crispr/cas–based In Vitro Diagnosticsmentioning

confidence: 99%

CRISPR‐Cas system for biomedical diagnostic platforms

Wang

Cui

2020

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“…ZIKV was first isolated from rhesus monkey 766 in the Zika forest in Uganda in 1947 as part of a yellow fever surveillance study [13]. This was followed by the first recorded human infections in 1952 in Uganda and Tanzania [14][15][16]. There were 14 sporadic cases reported between the 1960s and 80s without serious consequences since the disease presented as a self-limiting febrile illness [17,18].…”

Section: Introductionmentioning

confidence: 99%

Importance of Zika Virus NS5 Protein for Viral Replication

2019

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Zika virus is the latest addition to an ever-growing list of arboviruses that are causing outbreaks with serious consequences. A few mild cases were recorded between 1960 and 1980 until the first major outbreak in 2007 on Yap Island. This was followed by more severe outbreaks in French Polynesia (2013) and Brazil (2015), which significantly increased both Guillain-Barre syndrome and microcephaly cases. No current vaccines or treatments are available, however, recent studies have taken interest in the NS5 protein which encodes both the viral methyltransferase and RNA-dependent RNA polymerase. This makes it important for viral replication alongside other important functions such as inhibiting the innate immune system thus ensuring virus survival and replication. Structural studies can help design inhibitors, while biochemical studies can help understand the various mechanisms utilized by NS5 thus counteracting them might inhibit or abolish the viral infection. Drug repurposing targeting the NS5 protein has also proven to be an effective tool since hundreds of thousands of compounds can be screened therefore saving time and resources, moreover information on these compounds might already be available especially if they are used to treat other ailments.

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“…This immune-mediated demyelinating neuropathy can rapidly evolve over a period of few days or more and can lead to paralysis or even death. [5][6][7] The initial symptoms of GBS include muscle weakness that starts from distal limbs which subsequently progresses to proximal limbs. [8] GBS may lead to respiratory failure requiring mechanical ventilation over 15% of cases.…”

Section: Guillain-barré Syndrome: Symptoms and Causesmentioning

confidence: 99%

“…[15,16] Infection by Campylobacter jejuni is identified as the most common inciting event although other agents such as herpes simplex virus (HSV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), Zika virus (ZIKV), Mycoplasma pneumoniae, Haemophilus influenza, and influenza have been reported. [7,[17][18][19][20][21][22] Vaccination to influenza has been implicated in GBS, although the evidence for this link is controversial. [23]…”

Section: Guillain-barré Syndrome: Symptoms and Causesmentioning

confidence: 99%

Influenza vaccination and Guillain–Barré syndrome: Reality or fear

Babazadeh

Afshar

Javanian

et al. 2019

Journal of Translational Internal Medicine

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Guillain–Barré syndrome (GBS) is an inflammatory disorder and an acute immune-mediated demyelinating neuropathy that causes reduced signal transmissions, progressive muscle weakness, and paralysis. The etiology of the syndrome still remains controversial and uncertain. GBS can be initiated and triggered by respiratory tract infections such as influenza, and intestinal infections such as Campylobacter jejuni. In addition, there is considerable evidence suggesting links between influenza vaccination and GBS. As reported previously, the incidence of GBS in individuals receiving swine flu vaccine was about one to two cases per million. Despite the influenza vaccine efficacy, its association with an immune-mediated demyelinating process can be challenging as millions of people get vaccinated every year. In this review we will discuss the association between influenza infection and vaccination with GBS by focusing on the possible immunopathological mechanisms.

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Zika virus: epidemiology, clinical aspects, diagnosis, and control of infection

Cited by 24 publications

References 107 publications

CRISPR‐Cas system for biomedical diagnostic platforms

CRISPR‐Cas system for biomedical diagnostic platforms

Importance of Zika Virus NS5 Protein for Viral Replication

Influenza vaccination and Guillain–Barré syndrome: Reality or fear

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