Zika: the continuing threat

Anderson, Tatum; Humphreys, Gary

doi:10.2471/blt.19.020119

Cited by 29 publications

(11 citation statements)

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“…At the peak of the epidemic in 2016, 216,207 probable cases of acute ZIKV disease were reported in Brazil, and it is estimated that 8,604 babies were born with malformations (128). In 2019, 1649 probable cases of ZIKV infections were reported in pregnant women, 447 of which were confirmed by laboratory tests (129).…”

Section: Infection In Pregnant Women and Congenital Effectsmentioning

confidence: 99%

Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

et al. 2020

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During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral infections, mainly during the first and second trimesters, that may cause congenital damage to the fetus. Recently, Zika virus (ZIKV) infection has gained great notoriety due to the occurrence of congenital ZIKV syndrome, characterized by fetal microcephaly, which results from the ability of ZIKV to infect placental cells and neural precursors in the fetus. Importantly, in addition to the congenital effects, studies have shown that perinatal ZIKV infection causes a number of disorders, including maculopapular rash, conjunctivitis, and arthralgia. In this paper, we contextualize the immunological aspects involved in the maternal-fetal interface and vulnerability to ZIKV infection, especially the alterations resulting in perinatal outcomes. This highlights the need to develop protective maternal vaccine strategies or interventions that are capable of preventing fetal or even neonatal infection.

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Section: Infection In Pregnant Women and Congenital Effectsmentioning

confidence: 99%

Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

et al. 2020

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“…Environmental DENV and ZIKV epidemic exposure was then assessed using pathogen-specific thermal thresholds derived from laboratory studies (ZIKV = 22.6-34. With endemic ZIKV circulation in Southeast Asia [44], and as temperature rises, there is a risk of ZIKV re-emergence in Fiji, with potentially extended transmission season in the near future. The findings demonstrate that ZIKV must still be considered a potential health threat in the Pacific, although no infected cases have been reported recently, which makes awareness raising and epidemic preparedness a public health priority.…”

Section: Mosquito-borne Diseases In the Pacific Region-a Review On Dementioning

confidence: 99%

Climate Change, Health and Mosquito-Borne Diseases: Trends and Implications to the Pacific Region

Filho

Scheday

Boenecke

et al. 2019

IJERPH

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Climate change is known to affect Pacific Island nations in a variety of ways. One of them is by increasing the vulnerability of human health induced by various climate change impacts, which pose an additional burden to the already distressed health systems in the region. This paper explores the associations between climate change and human health on the one hand, and outlines some of the health care challenges posed by a changing climate on the other. In particular, it describes the links between climate variations and the emergence of climate-sensitive infectious diseases, such as the mosquito-borne diseases dengue, chikungunya, and Zika. The paper also presents a summary of the key findings of the research initiatives Climate Change and Prevalence Study of ZIKA Virus Diseases in Fiji and the findings from the World Mosquito Program as two examples of public health action in the Pacific region.

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“…Those facts led the World Health Organization to declare ZIKV a global health problem ( WHO, 2016 ). Brazil had more than 200,000 reported cases of ZIKV at the peak of the 2016 emergency ( Spitz, 2019 ). The number of cases has now decreased in Brazil, but ZIKV continues to circulate and there is still the possibility of further outbreaks.…”

Section: Introductionmentioning

confidence: 99%

In silico predictions of protein interactions between Zika virus and human host

Pitta

Vasconcelos

Wallau

et al. 2021

PeerJ

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Background The ZIKA virus (ZIKV) belongs to the Flaviviridae family, was first isolated in the 1940s, and remained underreported until its global threat in 2016, where drastic consequences were reported as Guillan-Barre syndrome and microcephaly in newborns. Understanding molecular interactions of ZIKV proteins during the host infection is important to develop treatments and prophylactic measures; however, large-scale experimental approaches normally used to detect protein-protein interaction (PPI) are onerous and labor-intensive. On the other hand, computational methods may overcome these challenges and guide traditional approaches on one or few protein molecules. The prediction of PPIs can be used to study host-parasite interactions at the protein level and reveal key pathways that allow viral infection. Results Applying Random Forest and Support Vector Machine (SVM) algorithms, we performed predictions of PPI between two ZIKV strains and human proteomes. The consensus number of predictions of both algorithms was 17,223 pairs of proteins. Functional enrichment analyses were executed with the predicted networks to access the biological meanings of the protein interactions. Some pathways related to viral infection and neurological development were found for both ZIKV strains in the enrichment analysis, but the JAK-STAT pathway was observed only for strain PE243 when compared with the FSS13025 strain. Conclusions The consensus network of PPI predictions made by Random Forest and SVM algorithms allowed an enrichment analysis that corroborates many aspects of ZIKV infection. The enrichment results are mainly related to viral infection, neuronal development, and immune response, and presented differences among the two compared ZIKV strains. Strain PE243 presented more predicted interactions between proteins from the JAK-STAT signaling pathway, which could lead to a more inflammatory immune response when compared with the FSS13025 strain. These results show that the methodology employed in this study can potentially reveal new interactions between the ZIKV and human cells.

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Zika: the continuing threat

Abstract: The steep decline in Zika cases since 2016 has led to a perception that the threat posed by the virus has diminished. Recent outbreaks and global spread underline the need for continued vigilance. Tatum Anderson and Gary Humphreys report.

Cited by 29 publications

References 0 publications

Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

Climate Change, Health and Mosquito-Borne Diseases: Trends and Implications to the Pacific Region

In silico predictions of protein interactions between Zika virus and human host

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