Zika in travellers 1947–2017: a systematic review

Wilder‐Smith, Annelies; Chang, Chui Rhong; Leong, Wei Yee

doi:10.1093/jtm/tay044

Cited by 68 publications

(50 citation statements)

References 101 publications

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“…As a member of the Flaviviridae family, ZIKV was first identified in rhesus monkeys in Zika Forest of Uganda in 1947 and has explosively spread to additional countries and territories since 2013. ZIKV is transmitted through its mosquito vector, usually Aedes aegypti, or other potential routes such as sexual contact and maternal-fetal transmission (2,3). Most people infected are asymptomatic or have mild symptoms, presenting with rash, fever, conjunctivitis, arthralgia, or myalgia.…”

mentioning

confidence: 99%

Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA

Dai

et al. 2019

FASEB j.

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Recently, Zika virus (ZIKV) has generated extraordinary concern because of its severe neurotoxicity. Disturbingly, there is no vaccine or specific drug to prevent or treat the diseases caused by ZIKV infection. Thus, it is extremely urgent to characterize the pathogenesis of ZIKV. It has been documented that ZIKV can evade antiviral responses of host cells. Here, we demonstrate that ZIKV strain SZ‐WIV01 down‐regulates the production of type I IFN and IFN‐stimulated genes along with the expression of mitochondrial antiviral signaling protein (MAVS) and mediator of IFN regulatory factor 3 activation (MITA). In the mechanism, ZIKV nonstructural (NS) 3 and NS2B3 negatively regulate IFN‐related retinoic acid‐inducible gene I‐like receptor signaling pathway by targeting MAVS and MITA, respectively. Overexpression of ZIKV NS3 and NS2B3 dramatically inhibits expression of IFN‐β. ZIKV NS3 interacts with MAVS, and NS2B3 interacts with MITA, which catalyzes K48‐linked polyubiquitination of MAVS and MITA for degradation. Further investigations suggest that ZIKV NS2B3 impairs polyinosinicpolycytidylic acid‐triggered K63‐linked polyubiquitination of MITA, thereby subverting the activation of downstream sensors. Our study reveals an undiscovered mechanism for ZIKV to escape the innate immune response, providing new insights into clinical study of vaccines or effective drugs.—Li, W., Li, N., Dai, S., Hou, G., Guo, K., Chen, X., Yi, C., Liu, W., Deng, F., Wu, Y., Cao, X. Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA. FASEB J. 33, 9929–9944 (2019). http://www.fasebj.org

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confidence: 99%

Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA

Dai

et al. 2019

FASEB j.

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“…Due to our expertise related to mathematical modelling, and vectorial capacity – developed through DengueTools – we decided to focus our research in this area. As ZIKV was rapidly spread via travellers [82–87], we modelled the risk of ZIKV importations from Brazil into Europe [69,88]. We analysed and overlaid the monthly flows of airline travellers arriving into European cities from Zika affected areas across the Americas, and the predicted monthly estimates of the basic reproduction number of Zika virus in areas where Aedes mosquito populations reside in Europe.…”

Section: Discussionmentioning

confidence: 99%

Novel tools for the surveillance and control of dengue: findings by the DengueTools research consortium

Wilder‐Smith

Tissera

AbuBakar

et al. 2018

Global Health Action

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Background: Dengue fever persists as a major global disease burden, and may increase as a consequence of climate change. Along with other measures, research actions to improve diagnosis, surveillance, prevention, and predictive models are highly relevant. The European Commission funded the DengueTools consortium to lead a major initiative in these areas, and this review synthesises the outputs and findings of this work conducted from 2011 to 2016. Research areas: DengueTools organised its work into three research areas, namely [1] Early warning and surveillance systems; [2] Strategies to prevent dengue in children; and [3] Predictive models for the global spread of dengue.Research area 1 focused on case-studies undertaken in Sri Lanka, including developing laboratory-based sentinel surveillance, evaluating economic impact, identifying drivers of transmission intensity, evaluating outbreak prediction capacity and developing diagnostic capacity. Research area 2 addressed preventing dengue transmission in school children, with case-studies undertaken in Thailand. Insecticide-treated school uniforms represented an intriguing potential approach, with some encouraging results, but which were overshadowed by a lack of persistence of insecticide on the uniforms with repeated washing. Research area 3 evaluated potential global spread of dengue, particularly into dengue-naïve areas such as Europe. The role of international travel, changing boundaries of vectors, developing models of vectorial capacity under different climate change scenarios and strategies for vector control in outbreaks was all evaluated. Concluding remarks: DengueTools was able to make significant advances in methods for understanding and controlling dengue transmission in a range of settings. These will have implications for public health agendas to counteract dengue, including vaccination programmes. Outlook: Towards the end of the DengueTools project, Zika virus emerged as an unexpected epidemic in the central and southern America. Given the similarities between the dengue and Zika viruses, with vectors in common, some of the DengueTools thinking translated readily into the Zika situation.

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“…The presence of Ae. albopictus in France is monitored at the departmental level [8]. We selected these three diseases due to: i) the strong human transportation connections between mainland France and its tropical overseas territories: French Guiana and French West Indies (DEN, CHIK and ZIKA), Reunion Island (DEN, CHIK), and French Polynesia (DEN, CHIK and ZIKA); ii) the huge numbers of international tourists visiting France each year (up to 83 million visitors in 2016); and iii) the social, economic and political impacts of the CHIK epidemics on Reunion Island in 2005-2006, and in Emilia-Romagna, an Italian region close to southeastern France.…”

Section: Data Collection and Participantsmentioning

confidence: 99%

“…The Mediterranean basin, which offers suitable environmental conditions for mosquitoes, is considered to be at high risk for outbreaks of new arboviral diseases [2]. Since 2010, sporadic cases and small outbreaks of DEN and CHIK viruses have been recorded in Western and Southern Europe [3][4][5][6][7][8] A small outbreak of DEN with 15 cases took place in Croatia in 2010 [9] followed by a much larger epidemic on the Portuguese Island of Madeira in 2012 [10] with over 2,000 human cases. Autochtonous DEN transmission has been repeatedly reported in France as well since 2010 [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Low to medium-low risk perception for dengue, chikungunya and Zika outbreaks by infectious diseases physicians in France, Western Europe

et al. 2019

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BackgroundMany tropical countries are currently experiencing dengue (DEN), chikungunya (CHIK) and also more recently Zika (ZIKA) epidemics (particularly in Latin America). Although the risk of transmission and spread of these infections in temperate regions remains a controversial issue, vector-borne diseases have been widely reported in the media and have been the focus of preventive strategies by national and international policy-makers and public health authorities. In this context, we wanted to determine the extent of risk perception in infectious diseases (ID) physicians of the current and future risk of arboviral disease introduction, autochthonous case development and epidemic scenarios in France, Western Europe.MethodsTo this aim, we developed an original standardized questionnaire survey which was disseminated by the French Infectious Diseases Society to ID physician members.ResultsWe found that ID physicians perceived the risk of introduction and outbreak development of DEN, CHIK and ZIKA in France to be low to medium-low. Generalized Linear Model(s) identified medical school training, the extent of professional experience, and awareness of the French national plan regarding arboviral infections as significant predictors for lower risk perception among respondents.ConclusionDespite the fact that arboviral diseases are increasingly being imported into France, sometimes resulting in sporadic autochtonous transmission, French ID physicians do not perceive the risk as high. Better communication and education targeting health professionals and citizens will be needed to enhance the effectiveness of the French national plan to prepare against arboviral diseases.Electronic supplementary materialThe online version of this article (10.1186/s12889-019-7317-9) contains supplementary material, which is available to authorized users.

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Zika in travellers 1947–2017: a systematic review

Cited by 68 publications

References 101 publications

Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA

Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA

Novel tools for the surveillance and control of dengue: findings by the DengueTools research consortium

Low to medium-low risk perception for dengue, chikungunya and Zika outbreaks by infectious diseases physicians in France, Western Europe

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