Zerumbone, a phytochemical from Asian ginger is a novel inhibitor of Jak2/Stat3 inhibits promigratory gene expression, growth and migration of pancreatic cancer cells

Chakraborty, Arup; Coffman, Renee; Jorvig, Jessica E.

doi:10.1016/j.pan.2012.12.118

Cited by 10 publications

(9 citation statements)

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“…Zerumbone is a novel inhibitor of Jak2/Stat3, which inhibits promigratory gene expression, growth, and migration of human pancreatic carcinoma (PaCa) [ 94 ]. It also inhibits CXCL12-induced spread of pancreatic (PANC-28, MIA PaCa-2, and AsPC-1) tumors [ 64 ].…”

Section: Anticancer Properties Of Zerumbonementioning

confidence: 99%

Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Rahman

Abdullah

Yeap

et al. 2014

BioMed Research International

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Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.

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Section: Anticancer Properties Of Zerumbonementioning

confidence: 99%

Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Rahman

Abdullah

Yeap

et al. 2014

BioMed Research International

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“…[ 6 ], Alpinia galanga [ 7 ], Zingiber montanum [ 8 ], and Xylopia aethiopica [ 9 ]. Biological and therapeutic effects of ZER include anti-inflammatory [ 10 ], anticancer [ 11 , 12 ], antioxidant [ 13 ], antinociceptive [ 14 ], antihypercholesterolemia [ 15 ], antimicrobial [ 4 ], and immunomodulatory [ 16 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALB/c Mice Model

Rahman

Abdullah

Othman

et al. 2014

BioMed Research International

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Zerumbone- (ZER-) loaded nanostructure lipid carrier (NLC) (ZER-NLC) prepared for its antileukemia effect in vitro was evaluated for its toxicological effects by observing changes in the liver, kidney, spleen, lung, heart, and brain tissues, serum biochemical parameters, total haemogram, and bone marrow stem cells. The acute toxicity study for ZER-NLC was conducted by orally treating BALB/c mice with a single dose with either water, olive oil, ZER, NLC, or ZER-NLC for 14 days. The animals were observed for clinical and behavioral abnormalities, toxicological symptoms, feed consumption, and gross appearance. The liver, kidney, heart, lung, spleen, and brain tissues were assessed histologically. Total haemogram was counted by hemocytometry and microhematocrit reader. Bone marrow examination in terms of cellular morphology was done by Wright staining with bone marrow smear. Furthermore, serum biochemical parameters were determined spectrophotometrically. Grossly all treated mice, their investigated tissues, serum biochemical parameters, total haemogram, and bone marrow were normal. At oral doses of 100 and 200 mg/kg ZER-NLC there was no sign of toxicity or mortality in BALB/c mice. This study suggests that the 50% lethal dose (LD50) of ZER-NLC is higher than 200 mg/kg, thus, safe by oral administration.

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“…Zerumbone is known to exhibit numerous biological and pharmacological effects ( Figure 2 ) such as antitumor, antioxidant, antimicrobial, anti-nociceptive, hepatoprotective, immunomodulatory, anti-inflammatory, gastro-protective, and antiproliferative through modulation of various molecular targets ( Figure 3 ) and signaling mechanisms. Multiple reviews and extensive amount of studies have been performed detailing the molecular targets of zerumbone for various chronic diseases and have been reviewed in references elsewhere in great detail [ 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 43 , 45 , 46 , 47 , 49 , 56 , 59 , 60 ].…”

Section: Source Chemistry Physicochemical Properties and Pharmamentioning

confidence: 99%

“…Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oil of rhizomes from wild ginger, Zingiber zerumbet [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Zerumbone has been shown to possess strong antitumor [ 27 , 30 , 39 ], antioxidant [ 40 ], antimicrobial [ 41 ], anti-nociceptive [ 42 ], hepatoprotective [ 43 ], immunomodulatory [ 44 ], anti-inflammatory [ 33 , 45 , 46 ], and gastro-protective [ 40 ] activity. However, despite promising in-vitro and in-vivo studies demonstrating the therapeutic utility of zerumbone, its preclinical and clinical development has been limited due to its poor water solubility, poor absorption, or low bioavailability, limiting its targeting into various tissues and organs of interest.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone

Kesharwani

Bhat

2020

Medicina

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About 40–70% of drug molecules in the clinical development pipeline suffer from one of either low aqueous solubility, poor absorption, or extremely low bioavailability. Approximately 75% of the world population relies on traditional therapies and therefore there has been a growing interest in the utilization of natural compounds. Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oils of rhizomes from Zingiber zerumbet. It possesses strong antitumor, antioxidant, antimicrobial, and anti-inflammatory activity. However, despite promising preclinical studies demonstrating the therapeutic utility of zerumbone, its clinical development has been limited due to its low aqueous solubility, poor absorption, or associated low bioavailability. Multiple reviews demonstrating the pharmacological effects of zerumbone for various diseases have been published. However, to our knowledge, no review demonstrates the various formulation strategies developed to overcome the biopharmaceutical challenges of zerumbone. The purpose of this review is to provide a comprehensive perspective on zerumbone as a molecule for formulation development. A section related to pharmacokinetics, toxicity, and patents of zerumbone is included. This review provides the importance of developing novel formulations of zerumbone to overcome its biopharmaceutical challenges thereby advance its potential in the treatment of various diseases.

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Zerumbone, a phytochemical from Asian ginger is a novel inhibitor of Jak2/Stat3 inhibits promigratory gene expression, growth and migration of pancreatic cancer cells

Cited by 10 publications

References 0 publications

Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALB/c Mice Model

Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone

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