Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Rahman, Heshu Sulaiman; Abdullah, Rasedee; Yeap, Swee Keong; Othman, Hemn Hassan; Chartrand, Max Stanley; Namvar, Farideh; Abdul, Ahmad Bustamam; How, Chee Wun

doi:10.1155/2014/920742

Cited by 78 publications

(69 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The safety of zerumbone has been demonstrated in normal human cells [424]. On oral ingestion of zerumbone (20/40 mg/kg/day) for 8 weeks reduced hyperglycemia induced p38 mediated inflammatory response (infiltration of macrophages and increased levels of IL-1, -6 and TNF-α) and also reduced expression of intercellular adhesion molecule-1, MCP-1, TGF-β1 and fibronectin in nephropathic rats.…”

Section: Approachesmentioning

confidence: 99%

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey

Amedei

Aquilano

et al. 2015

Seminars in Cancer Biology

304

204

View full text Add to dashboard Cite

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adapative immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2, 3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer.

show abstract

Section: Approachesmentioning

confidence: 99%

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey

Amedei

Aquilano

et al. 2015

Seminars in Cancer Biology

304

204

View full text Add to dashboard Cite

show abstract

“…Similarly, Sidahmed et al evaluated the gastroprotective effect of zerumbone and the results depict that zerumbone promotes ulcer protection along with antioxidant activity and maintenance of mucus integrity [6]. It also has been shown to have anti-inflammatory and antioxidant properties [7]. Despite having promising pharmacological activities, its clinical development has been hindered because of its poor aqueous solubility and consequent low bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Development and In Vitro Evaluation of a Zerumbone Loaded Nanosuspension Drug Delivery System

Kit

Jagdish

et al. 2018

Crystals

View full text Add to dashboard Cite

Zerumbone extracted from the volatile oil of rhizomes available from the Zinigiber zerumbet has promising pharmacological activity. However, it has poor aqueous solubility and dissolution characteristics. To improve this, a nanosuspension formulation of zerumbone was developed. Nanosuspensions were formulated using high-pressure homogenization (HPH) with sodium dodecyl sulphate (SDS) and hydroxypropylmethylcellulose (HPMC) as stabilizers; the formulation was optimized and freeze dried. The optimized nanosuspension product was evaluated using an optical light microscope, photon correlation spectroscopy (PCS), polydispersity index, zeta potential, SEM, differential scanning calorimetry (DSC) and FT-IR. The physical stability of the nanosuspensions was evaluated for 30 days at 4 • C, 25 • C, and 37 • C. To validate the theoretical benefit of the increased surface area, we determined an in vitro saturation solubility and dissolution profile. The mean particle size, polydispersity index and zeta potential of the zerumbone nanosuspensions stabilized by SDS versus HPMC were found to be 211 ± 27 nm vs. 398 ± 3.5 nm, 0.39 ± 0.06 vs. 0.55 ± 0.004, and −30.86 ± 2.3 mV vs. −3.37 ± 0.002 mV, respectively. The in vitro saturation solubility and dissolution revealed improved solubility for the zerumbone nanosuspension. These results suggested that the nanosuspensionlization improves the saturation solubility and dissolution profile of zerumbone, which may facilitate its use as a therapeutic agent in the future.

show abstract

“…One of the chemopreventive strategies in the treatment of cancer is the induction of apoptotic cell death (7). Natural compounds are rich sources of anticancer agents that can induce apoptosis and DNA repair in response to mutations (10). Previous studies have shown that essential oils and compounds from medicinal herbs can be used to treat human diseases owing to their potent biological activities against abnormal physiological reactions in the body (19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

“…Natural compounds have an abundance of polyphenols and can be used as chemoprevention agents against malignant cancers in humans (10). Cnidium officinale Makino (CO) has been used historically in traditional Eastern medicine to enhance stamina and manage pain.…”

Section: Introductionmentioning

confidence: 99%

Cnidium officinale Makino extract induces apoptosis through activation of caspase-3 and p53 in human liver cancer HepG2 cells

Hong

Cruz

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. A number of diverse studies have reported the anticancer properties of Cnidium officinale Makino (CO). However, the apoptotic effect of this traditional medicinal herb in human hepatocellular carcinoma cells (HepG2) remains to be elucidated. Therefore, the present study investigated the ability of CO to reduce cell viability through apoptotic pathways. Cell viability was determined using the 2,3-bis [2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide assay. CO extract-induced apoptosis in HepG2 cells was assessed by Hoechst 33258 staining. The cell cycle was monitored using fluorescence-activated cell sorting analysis with propidium iodide staining. Furthermore, the present study explored whether various signaling molecules associated with HepG2 cell death were affected by CO treatment, including caspase-3, B-cell lymphoma 2 (Bcl-2), tumor protein p53 (p53), cyclin-dependent kinase 4 (CDK4) and cyclin D. The expression levels of these genes were examined by reverse-transcription polymerase chain reaction and western blotting. The expression levels of caspase-3 and p53 were upregulated with CO extract treatment, whereas those of Bcl-2, CDK4 and cyclin D were significantly downregulated. Cleaved caspase-3 expression was upregulated following treatment with CO extract in a dose-dependent manner. Collectively, the data suggest that CO extract has the potential to induce apoptosis of HepG2 cells and may act by suppressing the cell cycle, which leads to caspase-3 cleavage and p53 signaling.

show abstract

Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Cited by 78 publications

References 123 publications

Cancer prevention and therapy through the modulation of the tumor microenvironment

Cancer prevention and therapy through the modulation of the tumor microenvironment

Development and In Vitro Evaluation of a Zerumbone Loaded Nanosuspension Drug Delivery System

Cnidium officinale Makino extract induces apoptosis through activation of caspase-3 and p53 in human liver cancer HepG2 cells

Contact Info

Product

Resources

About