Zero-valent Fe confined mesoporous silica nanocarriers (Fe(0) @ MCM-41) for targeting experimental orthotopic glioma in rats

Shevtsov, Maxim; Parr, Marina A.; Ryzhov, V. A.; Zemtsova, E. G.; Arbenin, A. Yu.; Ponomareva, A. N.; Смирнов, В. М.; Multhoff, Gabriele

doi:10.1038/srep29247

Cited by 34 publications

(21 citation statements)

References 50 publications

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“…Fe‐based nanomaterials, such as zerovalent Fe [ 87 ] and FePt, [ 88 ] which can release Fe 2+ ions in the tumor environment, can lead to an intratumoral Fenton reaction. For example, Shi's group initiated the concept of CDT in 2016 by making amorphous Fe NPs, which can be decomposed in a mildly acidic tumor environment to release Fe 2+ , and subsequently induce a Fenton reaction with the overproduced H 2 O 2 in cancer cells to generate highly cytotoxic • OH against tumor growth.…”

Section: Therapeutic Applicationmentioning

confidence: 99%

Inorganic Nanoparticles Applied as Functional Therapeutics

Liu¹,

Kim

et al. 2020

Adv Funct Materials

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Inorganic nanoparticles (NPs) offer significant advantages to the biomedical field owing to their large surface area, controllable structures, diverse surface chemistry, and unique optical and physical properties. Researchers worldwide have shown that inorganic NPs and the released metal ions can act as therapeutic agents in targeted tissues or to cure various diseases without acute toxicity. In this progress report, the recent developments in inorganic NPs with different compositions directly used as therapeutics are discussed. First, the recent convergence of nanotechnology and biotechnology in biomedical applications as well as the unique functions, features, and advantages of inorganic NPs in biomedical applications are summarized. Thereafter, the biological effects of inorganic compositions in NPs which include balancing the intracellular redox environment, regulating the specific cellular signaling and cellular behaviors, and apoptosis are explained. In addition, the emerging therapeutic applications of inorganic NPs in various diseases are exemplified. Finally, the perspectives and challenges for overcoming the weaknesses of inorganic NPs as therapeutics are discussed. By carefully considering and investigating the biological effects of inorganic NPs and metal ions released from NPs, more promising inorganic NPs based therapeutic agents can be developed.

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Section: Therapeutic Applicationmentioning

confidence: 99%

Inorganic Nanoparticles Applied as Functional Therapeutics

Liu¹,

Kim

et al. 2020

Adv Funct Materials

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“…A glass reactor for vacuum impregnation was used to introduce iron chloride into the silica matrix [12]. Initially, the sample was degassed in pentane by ultrasound.…”

Section: Synthesis Of Iron Nanoparticles In Mesoporous Mcm-41 Silica mentioning

confidence: 99%

Structural Organization of Themagnetic Part of Smart Material Based on Nanoparticles of Iron or Magnetite in Pores of Mcm-41 Mesoporous Silica for Target Drug Delivery

Zemtsova

Ponomareva

Arbenin

et al. 2018

Reviews on Advanced Materials Science

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The important stage of the development of smart material for the target drug delivery is the construction of the magnetic part of this material, including mesoporous silica and magnetic nanoparticles (Fe3O4or Fe0). Such a systemwill allow carry outmagnetic decapsulation (excretion) of drug from smart material using the magnetic field of a given value in the right place of the body. The paper considers the features of synthesis mesoporous silica MCM-41 with various pore diameter (33-51 Å) and synthesis of superparamagnetic nanoparticles of magnetite or metallic iron in the pores of mesoporous silica. The dependence of magnetic properties of nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 from the pore diameters of MCM-41 templates is studied. It was found that the matrix has a decisive influence on the content of iron or magnetite nanoparticles. The saturation magnetization of the material increases with increasing pore size of the mesoporous matrix. Nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 exhibit superparamagnetism, that allows them to be used as a magnetic material for targeted drug delivery.

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“…During recent years, silica-based nanoparticles have gained vast attention in therapy, diagnosis, and theranostics [16]; albeit limited examples exist specifically for brain cancer treatment. A few promising studies have been published to date [17][18][19][20][21][22], suggesting that their advantageous characteristics should be exploitable also in this therapeutic area. The most prominent advantage of mesoporous silica nanoparticles (MSNs) is perhaps their drug delivery capability, being able to efficiently carry high payloads of poorly soluble drugs; equipped with controlled release functions, ability to cross biological barriers e.g.…”

Section: Introductionmentioning

confidence: 99%

Circumventing drug treatment? Polyethylenimine functionalized nanoparticles inherently and selectively kill patient-derived glioblastoma stem cells

Prabhakar

Merisaari

Joncour

et al. 2020

Preprint

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Glioblastoma (GB) is the most frequent malignant tumor originating from the central nervous system. Despite breakthroughs in treatment modalities for other cancer types, GB remains largely irremediable due to its high degree of intratumoral heterogeneity, infiltrative growth, and intrinsic resistance towards multiple treatments. These resistant and aggressive sub-populations of GBs including the glioblastoma stem cells (GSCs) can circumvent treatment. GSCs act as a reservoir of cancer-initiating cells; they are a major challenge for successful therapy. We have discovered, as opposed to well-reported anti-cancer drug based therapeutical approach for GB therapy, the role of polyethylenimine (PEI) in inducing selective death of patient-derived GSCs via lysosomal membrane rupturing. Even at very low doses (1 ug/ml), PEI surface-functionalized mesoporous silica nanoparticles (PEI-MSNs), without any additional anti-cancer drug, very potently and selectively killed multiple GSC lines. Very importantly, PEI-MSNs did not affect the survival of well-established GB cells, or other type of cancer cells even at 25x higher doses. Remarkably, any sign of predominant cell death pathways such as apoptosis and autophagy was absent. Instead, as a potential explanation for their GSC selective killing function, we demonstrate that the internalized PEI-MSNs accumulated inside the lysosomes, subsequently causing a rupture of the vulnerable lysosomal membranes, exclusively in GSCs. As a further evaluation, we observed blood-brain-barrier (BBB) permeability of these PEI-MSNs in vitro and in vivo. Taking together the recent indications for the vulnerability of GSCs for lysosomal targeting, and GSC selectivity of the PEI-MSNs described here, the results suggest that PEI-functionalized nanoparticles could have a potential role in the eradication of GSCs.

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Zero-valent Fe confined mesoporous silica nanocarriers (Fe(0) @ MCM-41) for targeting experimental orthotopic glioma in rats

Cited by 34 publications

References 50 publications

Inorganic Nanoparticles Applied as Functional Therapeutics

Inorganic Nanoparticles Applied as Functional Therapeutics

Structural Organization of Themagnetic Part of Smart Material Based on Nanoparticles of Iron or Magnetite in Pores of Mcm-41 Mesoporous Silica for Target Drug Delivery

Circumventing drug treatment? Polyethylenimine functionalized nanoparticles inherently and selectively kill patient-derived glioblastoma stem cells

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