Zebrafish Behavioral Models of Ageing

Brock, Alistair J.; Sudwarts, Ari; Parker, Matthew O.; Brennan, Caroline H.

doi:10.1007/978-3-319-33774-6_11

Cited by 8 publications

(6 citation statements)

References 103 publications

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“…However, the plant compounds were not tested individually, and further studies are needed to isolate and identify bioactive compounds in the mixture that could be used as Despite the promising antioxidant capacity of the phytochemical profiles of finger lime, mountain pepper, and tamarind extracts [5,7,58,59], there is limited understanding of their potential toxicological effects in live vertebrate models. We comprehensively assessed the effects of plant extracts from these plants on zebrafish, a high-throughput in vivo model with ~75% genetic homology and high physiological and behavioural similarities to humans [60,61].…”

Section: Malformationsmentioning

confidence: 99%

Phytochemical and Safety Evaluations of Finger Lime, Mountain Pepper, and Tamarind in Zebrafish Embryos

et al. 2022

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Plants play a pivotal role in drug discovery, constituting 50% of modern pharmacopeia. Many human diseases, including age-related degenerative diseases, converge onto common cellular oxidative stress pathways. This provides an opportunity to develop broad treatments to treat a wide range of diseases in the ageing population. Here, we characterize and assess the toxicological effects of finger lime (Citrus australasica), mountain pepper (Tasmannia lanceolata), and small-leaved tamarind (Diploglottis australis) extracts. The characterization demonstrates that these Australian native plants have antioxidant potential and, importantly, they have high concentrations of distinct combinations of different antioxidant classes. Using zebrafish larvae as a high-throughput pre-clinical in vivo toxicology screening model, our experiment effectively discriminates which of these extracts (and at what exposure levels) are suitable for development towards future therapies. The LC50-96h for finger lime and tamarind were >480 mg/L, and 1.70 mg/L for mountain pepper. Critically, this work shows that adverse effects are not correlated to the properties of these antioxidants, thus highlighting the need for combining characterization and in vivo screening to identify the most promising plant extracts for further development. Thus, we present a high-throughput pre-clinical screening that robustly tests natural plant products to utilize the diversity of antioxidant compounds for drug development.

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Section: Malformationsmentioning

confidence: 99%

Phytochemical and Safety Evaluations of Finger Lime, Mountain Pepper, and Tamarind in Zebrafish Embryos

et al. 2022

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“…Zebrafish ( Danio rerio ) has emerged as a species of choice for their genetic and neurological similarity to humans, high reproduction rate, and ease of maintenance ( Miklósi & Andrew, 2006 ; Lawrence, 2007 ; Spence et al, 2008 ; Brock et al, 2017 ). Their complex locomotory patterns have been extensively analyzed in biomechanics research, addressing the development of balance ( Fuiman & Webb, 1988 ; Bianco et al, 2012 ; Ehrlich & Schoppik, 2017 ), the mechanisms underpinning aggregation into schools ( Miller & Gerlai, 2012 ; Laan, Gil de Sagredo & De Polavieja, 2017 ), and neuromuscular transmission ( Borla et al, 2002 ; Drapeau et al, 2002 ; Fetcho, Higashijima & McLean, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Zebrafish swimming in the flow: a particle image velocimetry study

Mwaffo

Zhang

Cruz

et al. 2017

PeerJ

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Zebrafish is emerging as a species of choice for the study of a number of biomechanics problems, including balance development, schooling, and neuromuscular transmission. The precise quantification of the flow physics around swimming zebrafish is critical toward a mechanistic understanding of the complex swimming style of this fresh-water species. Although previous studies have elucidated the vortical structures in the wake of zebrafish swimming in placid water, the flow physics of zebrafish swimming against a water current remains unexplored. In an effort to illuminate zebrafish swimming in a dynamic environment reminiscent of its natural habitat, we experimentally investigated the locomotion and hydrodynamics of a single zebrafish swimming in a miniature water tunnel using particle image velocimetry. Our results on zebrafish locomotion detail the role of flow speed on tail beat undulations, heading direction, and swimming speed. Our findings on zebrafish hydrodynamics offer a precise quantification of vortex shedding during zebrafish swimming and demonstrate that locomotory patterns play a central role on the flow physics. This knowledge may help clarify the evolutionary advantage of burst and cruise swimming movements in zebrafish.

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“…Since it is a long-term process, longitudinal studies are needed to obtain the key data about markers that can affect personality change. Animal lifespan is usually shorter than in humans, and such studies in animals take less time [188]. It is also easier to observe each day of an animal's life in laboratory conditions and manipulate these conditions to determine how they affect personality development during the lifespan.…”

Section: Discussionmentioning

confidence: 99%

Cross-species Analyses of Intra-species Behavioral Differences in Mammals and Fish

et al. 2020

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Multiple species display robust behavioral variance among individuals due to genetic, genomic, epigenetic, neuroplasticity and environmental factors. Behavioral individuality has been extensively studied in various animal models, including rodents and other mammals. Recently, fish, such zebrafish (Danio rerio), have emerged as powerful aquatic model organisms with overt individual differences in behavioral, nociceptive and other CNS traits. Here, we evaluate individual behavioral differences in mammals and fish, emphasizing the importance of crossspecies analyses of intraspecies variance in experimental models of normal and pathological CNS functions.

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Zebrafish Behavioral Models of Ageing

Cited by 8 publications

References 103 publications

Phytochemical and Safety Evaluations of Finger Lime, Mountain Pepper, and Tamarind in Zebrafish Embryos

Phytochemical and Safety Evaluations of Finger Lime, Mountain Pepper, and Tamarind in Zebrafish Embryos

Zebrafish swimming in the flow: a particle image velocimetry study

Cross-species Analyses of Intra-species Behavioral Differences in Mammals and Fish

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