Zearalenone Induced Cytotoxicity and Oxidative Stress in Human Peripheral Blood Leukocytesevita

Viera-Limón, Martha Josefina; Morlett-Chávez, Jesús Antonio; Sierra‐Rivera, Crystel Aleyvick; Luque-Contreras, Diana; Zugasti–Cruz, Alejandro

doi:10.4172/2476-2067.1000102

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…At high doses, ZEN induces an overproduction of ROS, thus can lead to oxidative stress. This stress can be correlated with DNA damage and mitochondrial degeneration that can lead to cell apoptosis [73,74]. At lower doses, ZEN is known for its carcinogenic activity in the liver and reproductive system [75].…”

Section: Zearalenonementioning

confidence: 99%

Genetics and Environmental Factors Associated with Resistance to Fusarium graminearum, the Causal Agent of Gibberella Ear Rot in Maize

et al. 2023

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Maize is one of the most important food and feed sources at the worldwide level. Due to this importance, all the pathogens that can infect this crop can harm both food safety and security. Fungi are the most important pathogens in cultivated maize, and Fusarium spp. are one of the most important families. Reduction in yield and production of dangerous mycotoxins are the main effects of Fusarium spp. infection. Fusarium graminearum (part of the Fusarium graminearum species complex) is one the most important fungi that infect maize, and it is the causative agent of Gibberella ear rot (GER). The main characteristics of this species include its ability to infect various species and its varying infection pressures across different years. This fungus produces various harmful mycotoxins, such as deoxynivalenol, zearalenone, butanolide, and culmorin. Infection can start from silk channels or from ear wounds. In the first case, the environmental conditions are the most important factors, but in the second, a key role is played by the feeding action of lepidopteran larvae (in Europe, Ostrinia nubilalis). All these factors need to be taken into account to develop a successful management strategy, starting from cropping methods that can reduce the source of inoculum to the direct control of the fungus with fungicide, as well as insect control to reduce ear wounds. But, the most important factor that can reduce the effects of this fungus is the use of resistant hybrids. Different studies have highlighted different defensive methods developed by the plant to reduce fungal infections, like fast drying of silk and kernels, chemical compounds produced by the plant after infection, and mechanical protection from insects’ wounds. The aim of this paper is to review the scientific evidence of the most important management strategies against GER in maize and to highlight the genetic basis which is behind hybrid resistance to this disease, with a focus on genes and QTLs found in studies conducted across the world and with different types of maize from tropical cultivars to European flint.

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Section: Zearalenonementioning

confidence: 99%

Genetics and Environmental Factors Associated with Resistance to Fusarium graminearum, the Causal Agent of Gibberella Ear Rot in Maize

et al. 2023

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“…Del mismo modo, induce citotoxicidad en células hepáticas humanas CCL13 al inhibir la proliferación celular (> 50%) de manera dependiente de la dosis (10 a 150 µM) y tiempo de 12 y 24 horas de exposición a concentraciones de ZEA de hasta 200 µM [34]. Así mismo, ZEA disminuyó la viabilidad celular (36%) en leucocitos humanos con un efecto citotóxico dependiente de la concentración a un tiempo de exposición corto (1 hora) [35]. También, ZEA posee una acción inhibidora en la proliferación ce células MTEC1 (línea celular epitelial tímica 1).…”

Section: Efecto Citotóxico De Zea Sobre Células Hepg2unclassified

Cuantificación de Zearalenona en el arroz cultivado en Norte de Santander y su efecto citotóxico sobre las células HepG2

Botia¹,

Méndez²,

Contreras³

2023

BISTUA

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La contaminación por micotoxinas en el arroz puede ser considerado un riesgo para la salud de los consumidores. Por lo tanto, el objetivo de esta investigación fue cuantificar la concentración de ZEA y determinar la presencia de Fusarium spp. en arroz de cultivo de 4 municipios de Norte de Santander, así mismo, evaluar el efecto citotóxico de un patrón de ZEA (10 µg/ml), a través del ensayo de bromuro de 3-(4,5-dimetil-2-tiazolil) -2, 5-difeniltetrazolio (MTT), y la inducción de cambios morfológicos apoptóticos por microscopia electrónica de trasmisión en la línea celular HepG2. En los resultados obtenidos se pudo establecer la presencia de ZEA en 3 de las 15 muestras de arroz de cultivo analizadas en concentraciones entre 98 y 490 ?g/Kg, de igual manera, se determinó, la presencia de Fusarium spp., presuntivamente, teniendo en cuenta la caracterización fenotípica de acuerdo a la morfología macroscópica y microscópica, en tres medios de cultivo (PDA, Avena, DG18). Además, los resultados de citotoxicidad indicaron que ZEA causó una disminución notable de la actividad metabólica, y a su vez una reducción significativa en los porcentajes de proliferación celular, de manera dependiente de la concentración y el tiempo de exposición, ya que a partir de 5 µM se obtuvo valores de 60,88% y 66,020%, a las 48 y 72 horas respectivamente; de igual manera, se evidenció la inducción de cambios morfológicos característicos de la muerte celular por apoptosis.

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“…Following OTA exposure, apoptotic signal-regulated kinase 1 (ASK-1) expression is increased, which controls ROS generation and lowers mitochondrial membrane potential ( 57 ). According to the research, both in vivo and in vitro , ZEA causes DNA damage and oxidative stress ( 58 , 59 ). DNA damage and elevated ROS levels were caused by ZEA and its analogs, including α-ZEL and β-ZEL ( 60 ).…”

Section: Principal Toxicological Mechanisms Induced By Mycotoxinsmentioning

confidence: 99%

Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review

Fang

Liu

2022

Front. Vet. Sci.

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Animal feed can easily be infected with molds during production and storage processes, and this can lead to the production of secondary metabolites, such as mycotoxins, which eventually threaten human and animal health. Furthermore, livestock production is also not free from viral infections. Under these conditions, the essential trace element, selenium (Se), can confer various biological benefits to humans and animals, especially due to its anticancer, antiviral, and antioxidant properties, as well as its ability to regulate immune responses. This article reviews the latest literature on the antagonistic effects of Se on mycotoxin toxicity and viral infections in animals. We outlined the systemic toxicity of mycotoxins and the primary mechanisms of mycotoxin-induced toxicity in this analysis. In addition, we pay close attention to how mycotoxins and viral infections in livestock interact. The use of Se supplementation against mycotoxin-induced toxicity and cattle viral infection was the topic of our final discussion. The coronavirus disease 2019 (COVID-19) pandemic, which is currently causing a health catastrophe, has altered our perspective on health concerns to one that is more holistic and increasingly embraces the One Health Concept, which acknowledges the interdependence of humans, animals, and the environment. In light of this, we have made an effort to present a thorough and wide-ranging background on the protective functions of selenium in successfully reducing mycotoxin toxicity and livestock viral infection. It concluded that mycotoxins could be systemically harmful and pose a severe risk to human and animal health. On the contrary, animal mycotoxins and viral illnesses have a close connection. Last but not least, these findings show that the interaction between Se status and host response to mycotoxins and cattle virus infection is crucial.

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Zearalenone Induced Cytotoxicity and Oxidative Stress in Human Peripheral Blood Leukocytesevita

Cited by 7 publications

References 26 publications

Genetics and Environmental Factors Associated with Resistance to Fusarium graminearum, the Causal Agent of Gibberella Ear Rot in Maize

Genetics and Environmental Factors Associated with Resistance to Fusarium graminearum, the Causal Agent of Gibberella Ear Rot in Maize

Cuantificación de Zearalenona en el arroz cultivado en Norte de Santander y su efecto citotóxico sobre las células HepG2

Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review

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