Zearalenone exposure mediated hepatotoxicity via mitochondrial apoptotic and autophagy pathways: Associated with gut microbiome and metabolites

Li, Yuanliang; Yi, Jiangnan; Zeng, Qiwen; Liu, Yingwei; Yang, Bijing; Liu, Bingxian; Li, Yangwei; Mehmood, Khalid; Hussain, Riaz; Tang, Zhaoxin; Zhang, Hui; Liu, Ying

doi:10.1016/j.tox.2021.152957

Cited by 21 publications

(14 citation statements)

References 79 publications

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“…80 On the one hand, ZEN intake causes liver histological changes as well as increased liver weight. 30,81,82 On the other hand, ZEN ingestion leads to changes in biochemical and antioxidant parameters. [81][82][83] In addition, when exogenous toxic substances enter the body, the liver secretes various xenobiotic enzymes to convert them into more hydrophilic and polar metabolites.…”

Section: Food and Function Reviewmentioning

confidence: 99%

“…84 Furthermore, ZEN affects the liver by interacting with metabolites and the gut microbiota. 30 In addition, it has been reported that ZEN can also cause nephrotoxicity. 85 ZEN and its derivatives induce immunotoxicity independent of the estrogenic potential of their structure.…”

Section: Food and Function Reviewmentioning

confidence: 99%

“…84 Furthermore, ZEN affects the liver by interacting with metabolites and the gut microbiota. 30 In addition, it has been reported that ZEN can also cause nephrotoxicity. 85…”

Section: Zen-induced Systemic Toxicity In Humans and Animalsmentioning

confidence: 99%

“…26,27 In the past decades, many studies have been carried out on the possible toxic effects of ZEN on the body and its mechanisms of action. [28][29][30][31] At the same time, there are increasingly more studies on natural compounds protecting the body against ZEN through dietary intervention. [32][33][34] Based on the current research, this paper reviews the existence of ZEN in different countries and summarizes the various toxic effects of ZEN and its mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of zearalenone and its nutritional intervention by natural products

et al. 2022

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Section: Food and Function Reviewmentioning

confidence: 99%

Section: Food and Function Reviewmentioning

confidence: 99%

“…84 Furthermore, ZEN affects the liver by interacting with metabolites and the gut microbiota. 30 In addition, it has been reported that ZEN can also cause nephrotoxicity. 85…”

Section: Zen-induced Systemic Toxicity In Humans and Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicity of zearalenone and its nutritional intervention by natural products

et al. 2022

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“…The estrogenic-like effect of ZON results in sterility, feminization of male animals, decrease in the survival of embryos, leading to significant economic losses among farmers [7]. Moreover, ZON was found to exhibit hepatotoxic [11], hematotoxic [7], immunotoxic [12], and genotoxic [13] effects. It is known that ZON is heat stable (up to 150 °C) and does not degrade during feed processing [14].…”

Section: Introductionmentioning

confidence: 99%

Zearalenone-selective biomimetic-based sensor system and its validation for real samples’ analysis

et al. 2022

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The paper presents the calibration and validation of a recent biomimetic-based fluorescent sensor system for the analysis of zearalenone (ZON) contamination in cereals. Methods. ZONspecific biomimetic sensing elements in a form of molecularly imprinted polymer (MIP) membrane were prepared by the in-situ polymerization method using cyclododecyl-2,4dihydroxybenzoate as a dummy template molecule and ethylene glycol methacrylate phosphate (EGMP) as a functional monomer. The detection is based on the fluorescence of ZON selectively adsorbed on the MIP membrane surface, which is registered by the spectrofluorimeter. Results. A biomimetic-based sensor system was calibrated for zearalenone analysis in cereal food products. The working range of the sensor system as well as its detection limit and the selectivity were examined. The calibrated biomimetic-based sensor system was successfully validated using maize and wheat flour with mean recoveries about 109 %. Conclusions. Calibration and validation studies of the novel ZON-selective biomimetic-based sensor system were successfully performed in cooperation with SE Ukrmetrteststandard. The standardized biomimetic-based fluorescent sensor system holds great potential to provide reliable prevention instrument against ZON contamination in cereals-based food products and feeding stuff.

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SSThe coexistence and diversity of Candidatus methylomirabilis oxyfera-like and anammox bacteria in sediments of an urban eutrophic lake

Wang

et al. 2022

Int Microbiol

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Zearalenone exposure mediated hepatotoxicity via mitochondrial apoptotic and autophagy pathways: Associated with gut microbiome and metabolites

Cited by 21 publications

References 79 publications

Toxicity of zearalenone and its nutritional intervention by natural products

Toxicity of zearalenone and its nutritional intervention by natural products

Zearalenone-selective biomimetic-based sensor system and its validation for real samples’ analysis

SSThe coexistence and diversity of Candidatus methylomirabilis oxyfera-like and anammox bacteria in sediments of an urban eutrophic lake

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