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Romeu, A.; Monzó, Ana; Peiró, Teresa; Diez, E.; Peinado, José A.; Quintero, Luis Alberto Zarco

doi:10.1023/a:1021127410300

Cited by 25 publications

(2 citation statements)

References 21 publications

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“…It is even more puzzling when we consider that in non-suppressed in vivo cycles, circulating estrogen and progesterone levels were found sufficient [ 27 ] and almost identical when these triggering options were compared. Moreover, pregnancy rates were similar [ 27 , 28 ]. A possible explanation can arise from the LH/hCG receptor in the reproductive tract along with the prolonged half-life of hCG as compared to LH.…”

Section: Introductionmentioning

confidence: 99%

hCG Triggering in ART: An Evolutionary Concept

Klement

Shulman

2017

IJMS

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Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.

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Section: Introductionmentioning

confidence: 99%

hCG Triggering in ART: An Evolutionary Concept

Klement

Shulman

2017

IJMS

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“…The incidence of EFS after a GnRH-a trigger has similar rate with hCG trigger [ 9 – 11 ]. Despite this, GnRH-a may still cause adverse reactions after the trigger, and relevant cases have been reported by many researchers [ 12 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

Low LH level does not indicate poor IVF cycle outcomes with GnRh-a single trigger: a retrospective analysis

Li¹,

Wang

He³

et al. 2022

BMC Pregnancy Childbirth

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Objective To compare the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes between patients with low and normal serum luteinizing hormone (LH) levels on the day after a gonadotropin-releasing hormone agonist (GnRH-a) single trigger. We further investigated the efficacy of human chorionic gonadotropin (hCG) retrigger on IVF cycle outcomes in patients with low LH levels after GnRH-a single trigger. Methods We retrospectively analyzed 957 infertile patients (tubal factor, ovulation disorders, male sperm factor, or unexplained infertility) who were treated with IVF/ICSI at the Chengdu Xinan Gynecology Hospital from July 2017 to December 2020. Patients received sufficient GnRH-a single trigger were divided into two groups based on the serum LH levels on the next day of trigger: normal serum LH levels (≥ 10 mIU/mL) group (control group, n = 906) and low LH levels (< 10 mIU/mL) group (experimental group, n = 51). And the efficacy of hCG retrigger on IVF/ICSI cycle outcomes in 10 patients with low LH levels after GnRH-a single trigger. Results There were no significant differences in IVF/ICSI cycle outcomes, including egg yield, two pronuclei fertilization rate, excellent embryo rate, or live birth rate of frozen-thawed embryos between patients with low and normal LH levels after GnRH-a trigger. It showed significantly higher risk of ovarian hyperstimulation syndrome in the group of low LH levels [ 0.7%(1/137) vs. 8.5%(4/47), P = 0.016] compared with the group of normal LH levels who received GnRH-a single trigger. The hCG retrigger had no obvious efficacy on cycle outcomes in patients with low LH levels, including oocytes retrieved, fertilization rate, embryo conditions, and live birth rate of frozen-thawed cycles. Conclusion The IVF/ICSI cycle outcomes of patients with low LH levels on the day after GnRH-a administration were similar to those of patients with normal LH levels. Blood LH test might not be required on the day following the trigger. The hCG retrigger did not have any effect on the cycle outcomes, suggesting that immediate retriggering with hCG was unnecessary.

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