Synchronised approach for intrauterine insemination in subfertile couples.

Cantineau, Astrid E. P.; Janssen, Mirjam J; Cohlen, Ben J; Allersma, Thomas

doi:10.1002/14651858.cd006942.pub2

Cited by 40 publications

(16 citation statements)

References 41 publications

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“…Intrauterine insemination (IUI) is a commonly used infertility treatment option for couples with unexplained subfertility, low-grade endometriosis, impotentia coeundi and sexual function disorders, as well as male subfertility [1]. The probability of conceiving with this infertility treatment depends on several factors, including age, reason for subfertility or infertility, absence/presence and type of ovarian stimulation, as well as the timing of insemination [2].…”

Section: Introductionmentioning

confidence: 99%

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The effect of slow release insemination on pregnancy rates: report of two randomized controlled pilot studies and meta-analysis

Marschalek

Franz

Gonen

et al. 2017

Arch Gynecol Obstet

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PurposeA modified application technique of intrauterine insemination (IUI) is slow release insemination (SRI), first described by Muharib et al. (Hum Reprod 7(2):227–229, 1992), who postulated higher pregnancy rates with a slow release of spermatozoa for 3 h.MethodsTo investigate this approach, two randomized controlled, cross-over pilot studies were performed from 2004 to 2006 in Israel and Germany to compare SRI with the standard bolus IUI. We aimed to present the results and perform a meta-analysis on available data for SRI. Univariate comparisons of pregnancy rates were performed using one-tailed z tests for method superiority. For meta-analysis, a fixed-effect Mantel–Haentzel weighted average of relative risk was performed.ResultsFifty treatment cycles (IUI: n = 25, SRI: n = 25) were performed in Germany, achieving four pregnancies (IUI: 4%, SRI: 12%, p > 0.05). Thirty-nine treatment cycles (IUI: n = 19, SRI: n = 20) were performed in Israel achieving six pregnancies (IUI: 10.5%, SRI: 20%; p > 0.05). Meta-analysis of all eligible studies for SRI (n = 3) revealed a combined relative risk for pregnancy after SRI of 2.64 (95% CI 1.04–6.74), p = 0.02).ConclusionsIn conclusion, these results lend support to the hypothesis that the pregnancy rate might be improved by SRI compared to the standard bolus technique.

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Section: Introductionmentioning

confidence: 99%

“…Usually, IUI is performed around ovulation and, as the fertile timeframe is limited, the correct timing of the insemination seems to be important. However, the quality of evidence to determine the potential difference in effectiveness between different methods of synchronization of ovulation and insemination is low [1, 4, 5]. …”

Section: Introductionmentioning

confidence: 99%

The effect of slow release insemination on pregnancy rates: report of two randomized controlled pilot studies and meta-analysis

Marschalek

Franz

Gonen

et al. 2017

Arch Gynecol Obstet

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“…The mechanisms by which inhibin antagonizes activin actions are not fully understood. It has been shown that inhibin is capable of binding to type II activin and BMP receptors through its b (beta) subunit and preventing the recruitment of type I receptor, thus antagonizing the actions of activins [ 218 ] . This may be one of the mechanisms by which inhibins antagonize activin actions.…”

Section: Mechanism Of Action Of Activins Inhibins Follistatin and Amhmentioning

confidence: 99%

Clinical Reproductive Medicine and Surgery

Falcone¹,

Hurd²

2013

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“…The Cochrane review by Cantineau et al (2010), found no significant difference between different timing methods for IUI expressed as live birth rates, although the group sizes were small [hCG versus LH surge (OR: 1.0, 95% CI, 0.06-18)]. This review was also in agreement with the meta-analysis by Kosmas et al (2007), which showed that urinary LH surge detection remains as effective as hCG administration as a method for IUI timing in clomiphene citrate-IUI treatment (OR for pregnancy: 0.66, 95% CI, 0.35-1.21) in the subgroup with male infertility.…”

Section: Timing Of Inseminationmentioning

confidence: 99%

“…The updated Cochrane review (Cantineau et al, 2010) revealed that based on the results of five studies reporting pregnancy rate per couple in stimulated IUI cycles, double IUI resulted in more pregnancies than single IUI (Peto OR: 1.8; 95% CI, 1.4-2.4). There were no data for live birth per couple or ongoing pregnancies.…”

Section: Single Versus Double Inseminationmentioning

confidence: 99%

The role of intrauterine insemination in male infertility

Tijani

Bhattacharya

2010

Human Fertility

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Male infertility is a common condition and intrauterine insemination (IUI) is used to treat the mild to moderate forms. Male subfertility determination is usually based on routine semen analysis but recent publications have questioned its diagnostic and prognostic accuracy as well as the effectiveness of IUI itself, as a treatment modality. We carried out a structured review of the literature to assess the current evidence regarding the diagnosis of male infertility, the effectiveness and cost effectiveness of IUI in male infertility and factors that affect the outcome of IUI. There is still uncertainty regarding the criteria for diagnosing male infertility and predicting treatment outcome based on standard semen parameters. The presence of seminal defects compromises the outcome of IUI in comparison with unexplained infertility. The total motile sperm count (TMSC) appears to have a consistent, direct relationship with treatment outcome, but there is no definite predictive threshold for success. However, it is reasonable to offer IUI as first-line treatment if TMSC is greater than 10 million when balancing the risk and cost of alternate treatments, such as in vitro fertilization (IVF). Sperm DNA studies and sperm preparation techniques warrant further studies in order to establish their clinical relevance. There are limited data on the clinical and cost-effectiveness of IUI in male infertility and large high-quality randomized controlled trials are warranted. However the difficulties in organizing such a study, at the present time, are a matter for discussion.

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Synchronised approach for intrauterine insemination in subfertile couples.

Cited by 40 publications

References 41 publications

The effect of slow release insemination on pregnancy rates: report of two randomized controlled pilot studies and meta-analysis

The effect of slow release insemination on pregnancy rates: report of two randomized controlled pilot studies and meta-analysis

Clinical Reproductive Medicine and Surgery

The role of intrauterine insemination in male infertility

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