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Chang, Li‐Ling; Bai, Jane P. F.

doi:10.1023/a:1016024322209

Cited by 18 publications

(1 citation statement)

References 12 publications

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“…[7][8][9] Thus, to enhance patient compliance and convenience, there is a pressing need to investigate the possibility of administering insulin orally to replace the painful subcutaneous route, which is more natural, less invasive, and can be self-administered. 8,10,11 However, the oral delivery of insulin has two main barriers to overcome: (1) the solution is able to remain stable inside the gastrointestinal environment; [12][13][14][15] (2) it manages to pass the intestinal epithelium. 11,14,16 In order to overcome these obstacles, many strategies to enhance the oral delivery of insulin have been or are currently being pursued, such as co-administration with bioadhesive agents, synthesis of their stable derivatives and the development of special dosage forms by utilizing micro-or nanoparticles as a drug carrier.…”

Section: Introductionmentioning

confidence: 99%

Chitosan modified cerasomes incorporating poly (vinyl pyrrolidone) for oral insulin delivery

Jin

Pan

et al. 2014

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Chitosan modified cerasomes incorporating poly (vinyl pyrrolidone) for oral insulin delivery

Jin

Pan

et al. 2014

RSC Adv.

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Region-Dependent Role of the Mucous/Glycocalyx Layers in Insulin Permeation Across Rat Small Intestinal Membrane

et al. 2005

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The regional difference in the contribution of the mucous/glycocalyx layers in rat small intestine, as a diffusional or enzymatic barrier, to the absorption of insulin was investigated by in vitro studies. The mucous/glycocalyx layers from the duodenum, the jejunum, and the ileum in rat were successfully removed without damaging membrane integrity, by exposing them to a hyaluronidase solution in situ. In an in vitro transport experiment, the apparent permeability coefficient (P(app)) of insulin for the hyaluronidase-pretreated group was significantly increased compared to the PBS-pretreated (control) group in all small intestinal regions, and the P(app) of insulin in both PBS- and hyaluronidase-pretreated groups increased in the following order: duodenum < jejunum < ileum. On the other hand, irrespective of small intestinal regions, the P(app) of FD-4 and of antipyrine, respectively the passive para- and transcellular permeation marker, exhibited no significant differences between PBS- and hyaluronidase-pretreated group. In addition, a significant amount of insulin was degraded in the mucous/glycocalyx layers compartment removed by hyaluronidase pretreatment, and the degradation activity in the mucous/glycocalyx layers showed regional differences in the following order: duodenum > jejunum > ileum. These findings suggest that, irrespective of small intestinal regions, the mucous/glycocalyx layers contributed to insulin permeation predominantly as an enzymatic barrier, and not as a diffusional barrier. Furthermore, the variation of the enzymatic activities in the mucous/glycocalyx layers and in the brush-border membrane would be one factor that accounts for the regional differences in the transport of insulin.

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Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Lin

et al. 2019

Advanced Drug Delivery Reviews

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Untitled

Cited by 18 publications

References 12 publications

Chitosan modified cerasomes incorporating poly (vinyl pyrrolidone) for oral insulin delivery

Chitosan modified cerasomes incorporating poly (vinyl pyrrolidone) for oral insulin delivery

Region-Dependent Role of the Mucous/Glycocalyx Layers in Insulin Permeation Across Rat Small Intestinal Membrane

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

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