Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Lin, Yi-Chun; Mi, Fwu Long; Lin, Po‐Yen; Miao, Yang‐Bao; Huang, Tringyo; Chen, Kuan Hung; Chen, Chiung Tong; Chang, Yen; Sung, Hsing‐Wen

doi:10.1016/j.addr.2018.12.001

Cited by 34 publications

(20 citation statements)

References 96 publications

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“…The positive charge allows for the adhesion of chitosan‐materials to the highly negative mucous environment, through electrostatic interactions. Moreover, the interaction of chitosan with the negatively charged cell wall disrupts the phospholipid alignment and promotes cell penetration (Hamedi, Moradi, Hudson, & Tonelli, ; Lin et al, ; M Ways, Lau, & Khutoryanskiy, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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“…Delivery of insulin through the human lungs by inhalation is another non-invasive administration rout for systemic delivery that would receive considerable attention and high compliance. 29 The lungs have an enormous absorptive surface area (∼80-120 m 2 ), 10 extremely thin mucosal membrane, good supply of blood, low intracellular and extracellular enzyme activity and avoidance of first pass hepatic metabolism; so these properties make lungs a good site for systemic delivery of peptide and proteins. 20,30 Delivery of sufficient dose of drug to special target needs an efficient carrier.…”

Section: Pulmonary Administrationmentioning

confidence: 99%

“…Enormous absorptive surface area (~80-120 m 2 ) 10 Extremely thin (0.2 µm) mucosal membrane 10 Good supply of blood 55 Relatively resistant to most peptidases 10 Delivery of insufficient dose of drug because of patient 56 Rapid clearance by mucociliary clearance 10 Transdermal administration Inexpensive 56 Large surface 19 Low permeability of the stratum corneum 3 Possibility of skin hypersensitivity 55…”

Section: Pulmonary Administrationmentioning

confidence: 99%

Non-Invasive and Less Degradative Ways of Insulin Administration

Allahyari

Javadzadeh

2019

Pharm Sci

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Protein and peptide delivery systems attract great attention nowadays. They play crucial role in several diseases, but their way of administration has some disadvantages that makes patients dissatisfied. In this study, we choose insulin as a peptide that is used for type I and type II diabetic patients, but injection way of its usage is not suitable in diabetes as a chronic remedy. Although oral way is a needle-free one, but its bioavailability through that would be decreased because of degradation in gastro-intestine and consequently, further dosage should be used to get the desired hypoglycemic effect. Administration of insulin through non-parenteral and less enzymatic pathways, such as intranasal, pulmonary, transdermal, colon and vaginal routes, is new that attracts researchers’ attention considerably. Although the bioavailability of insulin may be lower than the current injection way, but it may be improved by some strategies like the use of permeation enhancers. There are also some limitations in each way, but propagation of them would result in improvement of patients’ quality of life and may cause some economic profits. The objective of this review was to introduce the convenient ways for long term insulin administration with few enzymatic barriers.

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“…In literature, it is seen that [18] insulin loaded chitosan‐alginate (CS/ALG) nanoparticles can drop the level of glucose in a significant manner with oral administration. Albeit CS and ALG have very suitable properties as building blocks in insulin delivery systems with their pH‐responsive and bioadhesive nature, it is known that after encapsulation into these biopolymers, the bioavailability of insulin stayed low after oral administration [19–20] . In this study, we developed a novel particulate system for oral insulin delivery by benefiting from the favorable properties of PCL, CS and ALG.…”

Section: Introductionmentioning

confidence: 99%

“…Albeit CS and ALG have very suitable properties as building blocks in insulin delivery systems with their pHresponsive and bioadhesive nature, it is known that after encapsulation into these biopolymers, the bioavailability of insulin stayed low after oral administration. [19][20] In this study, we developed a novel particulate system for oral insulin delivery by benefiting from the favorable properties of PCL, CS and ALG. As a core material, PCL nanoparticles were prepared and coated with layers of CS and ALG.…”

Section: Introductionmentioning

confidence: 99%

pH‐Sensitive Polymeric Poly (ϵ‐caprolactone) Core‐ Chitosan/Alginate Shell Particle System for Oral Insulin Delivery

et al. 2021

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Oral administration of the drugs is considered as one of the most convenient and comfortable routes. However, an effective oral delivery of insulin still remains a challenging and elusive goal, due to bioavailability problem. The aim of our work is to develop a pH sensitive polymeric system for the oral delivery of insulin based on a poly (ε-caprolactone) (PCL) core and shells of chitosan (CS) and alginate (ALG). The particles were prepared based on the double emulsion (water/oil/water) solvent evaporation method. The effect of blending Pluronic127 (F127) into the hydrophobic PCL matrix to improve its water permeability by increasing specific surface area. ALG have been chosen to provide the needed pH-sensitivity to the system. However, to coat the PCL surface with this anionic ALG layer a cationic CS layer has been added. The influence of each of the CS and ALG layers on the nanoparticle's physiochemical properties as well as on the encapsulation efficiency and the drug release behavior of the nanoparticles was investigated. The results showed that CS and ALG shells increased the stability of the nanoparticles. The in vitro release studies using two different pH environments (1.2 and 6.8) to simulate the physiological conditions in the gastrointestinal tract (GIT) showed that, the particles have pH-responsive release patterns. The kinetics studies showed that, the insulin release from all the particles formulations obey the Korsmeyer-Peppas kinetic model.

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Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Cited by 34 publications

References 96 publications

Carbohydrate‐based nanomaterials for biomedical applications

Carbohydrate‐based nanomaterials for biomedical applications

Non-Invasive and Less Degradative Ways of Insulin Administration

pH‐Sensitive Polymeric Poly (ϵ‐caprolactone) Core‐ Chitosan/Alginate Shell Particle System for Oral Insulin Delivery

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