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doi:10.1590/s1678-91992011000400007

Cited by 16 publications

(11 citation statements)

References 17 publications

(17 reference statements)

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“…Methanol extracts of Cymbopogan citratus, Andrographis paniculata, Momordica charantia, Ocimum sanctum, Pelargonium citrosum, and Citrus limon showed inhibitory effects on DENV type-1 (DENV-1) growth in Vero E6 cells with A. paniculata exhibiting the highest activity followed by M. charantia [50]. Similar findings were also reported in ethanol and aqueous extracts of A. paniculata leaves [84,85]. The ethanol extract possessed higher inhibitory potential (75%), attributable to the presence of polyphenols and terpenes [88].…”

Section: In Vitro Studiessupporting

confidence: 67%

“…Reduction in cytopathic effect-structural changes in host cell due to viral invasionis the major technique used for the detection of the extract's inhibitory capacity against DENV. Polar extracts such as aqueous [36,81,84], methanol [50,[84][85][86], and ethanol [87,88] have been reported to possess anti-dengue activity. The inhibitory potential is attributable to the presence of polyphenols and terpenes [88].…”

Section: In Vitro Studiesmentioning

confidence: 99%

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Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Saleh

Kamisah

2020

Biomolecules

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While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with Carica papaya and Euphorbia hirta were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections.

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Section: In Vitro Studiessupporting

confidence: 67%

Section: In Vitro Studiesmentioning

confidence: 99%

Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Saleh

Kamisah

2020

Biomolecules

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“…Fruit picking is virtually limited to extractivism as hardly any plantations have been established (Narain et al, 1992;Neves et al, 2004;Neves and Carvalho, 2005). Moreover, S. tuberosa is used in traditional medicine and shows potential for its use in academic medicine Albuquerque and Oliveira, 2007;Almeida et al, 2010;Ferreira Júnior et al, 2011;Lins Neto et al, 2010;Silva et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Spondias tuberosa Arruda (Anacardiaceae), a threatened tree of the Brazilian Caatinga?

et al. 2016

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Spondias tuberosa Arr., a fructiferous tree endemic to the northeast Brazilian tropical dry forest called Caatinga, accounts for numerous benefits for its ecosystem as well as for the dwellers of the Caatinga. The tree serves as feed for pollinators and dispersers as well as fodder for domestic ruminants, and is a source of additional income for local smallholders and their families. Despite its vantages, it is facing several man-made and natural threats, and it is suspected that S. tuberosa could become extinct. Literature review suggests that S. tuberosa suffers a reduced regeneration leading to population decrease. At this juncture S. tuberosa cannot be considered threatened according to the International Union for Conservation of Nature Red List Categories and Criteria, as it has not yet been assessed and hampered generative regeneration is not considered in the IUCN assessment. The combination of threats, however, may have already caused an extinction debt for S. tuberosa. Due to the observed decline in tree density, a thorough assessment of the S. tuberosa population is recommended, as well as a threat assessment throughout the entire Caatinga.Keywords: Spondias tuberosa, natural regeneration, conservation, IUCN red list, Caatinga.Spondias tuberosa Arruda (Anacardiaceae), uma árvore ameaçada de extinção da Caatinga?Resumo Spondias tuberosa Arr., é uma árvore frutífera endêmica da Caatinga, floresta seca tropical localizada no Nordeste do Brasil. A árvore traz diversos benefícios para o ecossistema e para a população local. Ela serve de alimento tanto para polinizadores e dispersores quanto para ruminantes domésticos e é fonte de renda extra para os agricultores familiares da região. Apesar de seus benefícios, esta árvore enfrenta várias ameaças naturais e antrópicas que podem levar a sua extinção. A revisão da literatura científica sugere que S. tuberosa sofre de reduzida capacidade de regeneração, o que leva à diminuição da população. Todavia, S. tuberosa não é considerada uma espécie ameaçada de extinção de acordo com as categorias e critérios da Lista Vermelha da União Internacional para a Conservação da Natureza, já que a espécie ainda não foi avaliada e capacidade regenerativa reduzida não é considerado critério pelo UICN. A combinação de ameaças, entretanto, pode já ter levado ao débito de extinção da S. tuberosa. Devido ao declínio observado da densidade das árvores, recomenda-se uma avaliação completa da população de S. tuberosa e uma avaliação de todas as ameaças sofridas pela árvore na Caatinga.Palavras-chave: Spondias tuberosa, regeneracao natural, conservação, lista vermelha da UICN, Caatinga.

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“…Separation was performed with a linear gradient as previously described, with some modifications (Silva et al, 2011). Acetonitrile (C) and Milli-Q water (pH 2.8) (D) were used as the mobile phases with the following gradient elution programme: 0-15 min, isocratic elution with C:D (20:80 v/v); 17-25 min, linear change to C:D (40:60 v/v); and 25-40 min, isocratic elution with C:D (20:80 v/v).…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Chemical constituents of Calotropis procera latex and ultrastructural effects on Haemonchus contortus

Cavalcante

Morais

André

et al. 2020

Rev. Bras. Parasitol. Vet.

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This study aimed to evaluate the anthelmintic and ultrastructural effects of Calotropis procera latex on Haemonchus contortus. C. procera latex was twice centrifuged at 10,000×g and dialyzed to obtain a fraction rich in proteins, named LP (latex protein), and at 3,000 rpm to obtain a fraction rich in secondary metabolites, named LNP (latex non-protein). Specimens of H. contortus exposed to LNP, LP and PBS in the Adult Worm Motility Test (AWMT) were submitted to scanning (SEM) and transmission (TEM) electron microscopy to verify changes in their ultrastructure. Phytochemical tests in the LNP indicated the presence of phenols, steroids, alkaloids and cardenolides. High-Performance Liquid Chromatography (HPLC) characterized the presence of the compounds gallic acid and quercetin in the LNP. The protein content in the LP was 43.1 ± 1.1 mg/mL and 7.7 ± 0.3 mg/mL in LNP. In AWMT, LNP and LP inhibited the motility of 100% of the nematodes, with LNP being more effective than LP and ivermectin more effective than both (p <0.05). Cuticle changes were observed by SEM and TEM in nematodes treated with LP and LNP. Calotropis procera latex has anthelmintic effects against H. contortus, causing damage to its cuticle and other alterations in its ultrastructure.

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Cited by 16 publications

References 17 publications

Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Spondias tuberosa Arruda (Anacardiaceae), a threatened tree of the Brazilian Caatinga?

Chemical constituents of Calotropis procera latex and ultrastructural effects on Haemonchus contortus

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