“…Using analysis of adverse drug reactions datasets supplied by the European Medicines Agency, zolpidem has been shown to induce craving and to be frequently involved in abuse and withdrawal problems (Victorri-Vigneau et al, 2007;Chattopadhyay et al, 2016;Schifano et al, 2019). Furthermore, a large number of surveys emphasize the association between zolpidem and the occurrence of psychomotor agitation and behavioral alterations involving bizarre behaviors and sleep-related complex behaviors (sleep-shopping, sleep-eating, sleep-driving, and sleep-conversations) with amnesia for the episode (Mendelson, 1994;Morgenthaler and Silber, 2002;Monti et al, 2017;Ho et al, 2020;Orsolini et al, 2021). Interestingly, in patients taking high doses of zolpidem (600-2000 mg/day), euphoria, high energy, sociability, talkativeness, and feelings of well-being have been described (Victorri-Vigneau et al, 2007;Sabe et al, 2019), along with psychotic symptoms such as delusions and hallucinations (Markowitz and Brewerton, 1996;Sabe et al, 2019).…”