Yueju-Ganmaidazao Decoction confers rapid antidepressant-like effects and the involvement of suppression of NMDA/NO/cGMP signaling

Zhang, Hailou; Sun, Yan; Qian, Shiyu; Ge, Rui; Guo, Xiaoyan; Shen, Qin-Qin; Sheng, Li; Nie, Chunying; Zhang, Yi; Yao, Yao; Zhou, Tong; Wang, Wei; Xue, Wenhao; Chen, Gang

doi:10.1016/j.jep.2019.112380

Cited by 19 publications

(33 citation statements)

References 42 publications

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“…Chinese herb medicines have been widely used for treating mood disorders including depression (Choi et al, 2017; Xia et al, 2019; Xue et al, 2013; Zhang et al, 2015; Zhang et al, 2020). Several studies study found that chronic FRA administration had antidepressant‐like effects in rats in behavioral tests (Shi et al, 2020; Sun, Feng, & Yu, 2012; Zhang et al, 2012; Zhang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Novelty suppressed-feeding (NSF) assesses the animal's ability to resolve conflicts between anxiety-induced situations and motivation to seek appetite stimuli (Blasco-Serra, Gonzalez-Soler, Cervera-Ferri,Teruel-Marti, & Valverde-Navarro, 2017). In the NSF test, mice were food-deprived for 18 hr and then placed into an open-field arena (described above)(Duman, 2018;Tang et al, 2015;Zhang et al, 2020). A single pellet of the normal mouse chow was placed in the center of the open-field arena.…”

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confidence: 99%

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Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

Zhang

Chen

et al. 2020

Phytotherapy Research

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Several studies reported the relative antidepressant effects of Fructus Aurantii (FRA) with repeated treatment, the rapid antidepressant effects of FRA and the underlying mechanisms remained unclear. We, therefore, examined the rapid antidepressant actions of FRA in behavioral tests in mice and tested the underlying molecular mechanisms. We found FRA, like ketamine, reversed the behavioral deficits both in lipopolysaccharide(LPS)‐induced and learned helplessness (LH) models at 1 day after a single administration. FRA was also capable of increasing the expressions of protein kinase A/cAMP‐response element‐binding protein/brain‐derived neurotrophic factor (PKA/CREB/BDNF) signaling in hippocampus. Consistent with ketamine, FRA up‐regulated the expressions of GABAergic receptor (GAD67) and glutamatergic receptor 1 (GluR1) in mouse hippocampus both exposed to LPS and LH. Moreover, synaptic proteins such as postsynaptic density‐95 (PSD95) and synapsin1 were also up‐regulated by a single dose of FRA both in LH and LPS models, like ketamine. Finally, metadoxine (an antagonist of CREB) inhibited the antidepressant effects of FRA in tail suspension test (TST) and forced swimming test (FST) in LPS‐induced mice, which also blocked the phosphorylation of CREB and the expressions of neurotransmitters and synaptic molecules. Therefore, FRA had rapid antidepressant effects, which depended on PKA/CREB/BDNF pathway, subsequently regulated the downstream synaptic transmission.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

Zhang

Chen

et al. 2020

Phytotherapy Research

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“…The NOS3/sGC/cGMP/PRKG1 pathway is particularly important in cardiovascular and nervous systems. It can regulate smooth muscle relaxation, synaptic transmission, and adhesion of endothelial cells, blood cells, and epithelial cells [ 68 – 70 ]. CIF relieves the blood pressure of model rats, which may be affected by the NO pathway, thereby further improving the activation of vasoconstrictor factors ( Figure 14 ).…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology Prediction and Pharmacological Verification Mechanism of Yeju Jiangya Decoction on Hypertension

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Yeju Jiangya decoction (CIF) is an herbal formula from traditional Chinese medicine (TCM) for the treatment of hypertension. Materials and Methods. Based on the analysis of network pharmacology, combined with in animal experiments, the network pharmacology was used to explore the potential proteins and mechanisms of CIF against hypertension. The bioactive compounds of CIF were screened by using the platform, and the targets of hypertension and CIF were collected. Then, the Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interaction network (PPI) core targets were carried out, and the useful proteins were found by molecular docking technology. Finally, we used N-nitro-L-arginine (L-NNA) induced hypertension model rats to confirm the effect and mechanism of CIF on hypertension. Results. 14 bioactive compounds of CIF passed the virtual screening criteria, and 178 overlapping targets were identified as core targets of CIF against hypertension. The CIF-related target network with 178 nodes and 344 edges is constructed. The topological results show that quercetin and luteolin are the key components in the network. The key targets NOS3 (nitric oxide synthase 3) and NOS2 (nitric oxide synthase 2) were screened by the protein-protein interaction network. The analysis of target protein pathway enrichment showed that the accumulation pathway is related to the vascular structure of CIF regulation of hypertension. Further verification based on molecular docking results showed that NOS3 had the good binding ability with quercetin and luteolin. On the other hand, NOS3 has an important relationship with the composition of blood vessels. Furthermore, the animal experiment indicated that after the L-NNA-induced hypertension rat model was established, CIF intervention was given by gavage for 3 weeks, and it can decrease serum concentrations of endothelin-1 (ET-1) and thromboxane B2 (TXB2), increase the expression of nitric oxide (NO) and prostacyclin 2 (PGI2), and improve renal, cardiac, and aortic lesions. At the same time, it can reduce blood pressure and shorten vertigo time. Western blot (WB) and immunohistochemistry (IHC) analyses indicated that CIF may downregulate the expression of NOS3, guanylyl cyclase-alpha 1 (GC-α1), guanylyl cyclase-alpha 2 (GC-α2), and protein kinase CGMP-dependent 1 (PRKG1). These results suggest that CIF may play an antihypertensive role by inhibiting the activation of the NOS3/PRKG1 pathway. Conclusions. The results of this study indicate that CIF has the ability to improve target organs, protect endothelial function, and reduce blood pressure and that CIF might be a potential therapeutic drug for the prevention of hypertension. It provides new insight into hypertension and the potential biological basis and mechanism for CIF clinical research.

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“…On the contrary, there were no significant differences of the immobility time between K252a-treated groups and corticosterone -treated group also including TPx-MT2 (10 mg/kg) group. FST is a behavioral despair test useful for probing the pathological mechanism of depression and for the evaluation of antidepressant drugs (Zhang et al, 2019a). This neurobehavioral alteration was also ameliorated by red wine extract, thereby underlining the effectiveness of red wine as an antidepressant candidate.…”

Section: Immobility Time In the Fstmentioning

confidence: 99%

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Yan

Sun

et al. 2019

Ciência Téc. Vitiv.

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The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swimming test (FST). Red wine phenolic extracts treatment significantly reduced serum corticosterone levels. Moreover, it was found that red wine phenolic extract increased the brain-derived neurotrophic factor protein (BNDF) and tropomyosin-related kinase B (TrkB) phosphorylation and cAMP-responsive element binding protein (CREB) phosphorylation levels in the hippocampus and prefrontal cortex. However, K252a, an inhibitor of TrkB, completely abolished those antidepressant-like effects. These results suggested that the red wine phenolic extracts produce an antidepressant-like effect in corticosteronetreated mice, at least in part, which is possibly mediated by modulating hypothalamic-pituitary-adrenal (HPA) axis, BDNF, TrkB and CREB phosphorylation levels in the brain region of mice.

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Yueju-Ganmaidazao Decoction confers rapid antidepressant-like effects and the involvement of suppression of NMDA/NO/cGMP signaling

Cited by 19 publications

References 42 publications

Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

Network Pharmacology Prediction and Pharmacological Verification Mechanism of Yeju Jiangya Decoction on Hypertension

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

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