Yttrium oxide nanoparticle loaded scaffolds with enhanced cell adhesion and vascularization for tissue engineering applications

Augustine, Robin; Dalvi, Yogesh Bharat; Nath, Vishwa; Varghese, Ruby; Raghuveeran, Varun; Hasan, Anwarul; Thomas, Sabu; Sandhyarani, N.

doi:10.1016/j.msec.2019.109801

Cited by 66 publications

(54 citation statements)

References 64 publications

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“…A decrease in mechanical strength was noted at a higher content due to the agglomeration of nanomaterial. 20,22,23,40 The elongation at break was 7.5, 11.5, 11.1, 13.6, and 20.6% for the control, 0.1%, 0.5%, 1% and 2% incorporated CNCs, respectively indicating the more exible nature of the fabricated scaffolds than control. The tensile peak stress of the fabricated scaffolds is given in Fig.…”

Section: Mechanical Properties Of Pc Scaffoldsmentioning

confidence: 95%

“…An enhancement in the cell viability of PCL electrospun in the presence of nanoller has been reported earlier for tissue engineering. [16][17][18][19][20][21][22][23][24] The higher cell viability on composite scaffolds compared to pure PCL scaffold demonstrates the more biocompatible nature of PC scaffolds. Cell adhesion efficiency indicates the possible application of the scaffolds as a transplant material.…”

Section: Cell Viability and Adhesionmentioning

confidence: 99%

“…14 Polymer/CNCs composites have been studied from the last several decades in tissue engineering applications. [15][16][17][18][19][20][21][22][23][24] Besides, it has been found that the external stimuli including the electrical eld have wide effects on cell proliferation in the presence of CNCs. 25 It was observed that CNCs have low electroactive materials, and this property can be tuned by using highly conductive materials such as graphene or carbon nanotube with CNCs.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates

2019

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Section: Mechanical Properties Of Pc Scaffoldsmentioning

confidence: 95%

Section: Cell Viability and Adhesionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates

2019

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“…79,80 Several studies in literature report ability of different nanomaterials in exerting pro-angiogenic effects. In particular, gene expression analysis results concerning increased VEGF show Copper, Cerium or Yttriumcontaining nanoparticles to act through an hypoxia-induced mechanism, [81][82][83] whereas ZnO or Europium hydroxide nanoparticles to act through direct Ros generation. 84,85 Silver-doped C3 materials showed a significant VEGFA increase in transcript levels, as compared to untreated cells at both time points, in comparison to polystyrene, particularly at 7 days (1.42, 1.14 and 1.76-fold -p<0.0001; p<0.01; p<0.0001 for C3, C3Ag2 and C3Ag10, respectively), thus showing their angiogenic potential as well ( Figure 12A).…”

Section: Direct Cellular Effects Of the Silver-doped Mesoporous Carbomentioning

confidence: 99%

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Torre¹,

Giasafaki²,

Steriotis³

et al. 2019

IJN

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Introduction: Silver decorated mesoporous carbons are interesting systems that may offer effective solutions for advanced wound care products by combining the well-known antimicrobial activity of silver nanoparticles with the versatile properties of ordered mesoporous carbons. Silver is being used as a topical antimicrobial agent, especially in wound repair. However, while silver shows bactericidal properties, it is also cytotoxic at high concentrations. Therefore, the incorporation of silver into ordered mesoporous carbons allows to exploit both silver's biological effects and mesoporous carbons' biocompatibility and versatility with the purpose of conceiving silver-doped materials in light of the growing health concern in wound care. Methods: The wound healing potential of an ordered mesoporous carbon also doped with two different loadings of silver nanoparticles (2 wt% and 10 wt%), was investigated through a biological assessment study based on different assays (cell viability, inflammation, antibacterial tests, macrophage-conditioned fibroblast and human keratinocyte cell cultures). Results: The results show silver-doped ordered mesoporous carbons to positively condition cell viability, with a cell viability percentage >70% even for 10 wt% Ag, to modulate the expression of inflammatory cytokines and of genes involved in tissue repair (KRT6a, VEGFA, IVN) and remodeling (MMP9, TIMP3) in different cell systems. Furthermore, along with the biocompatibility and the bioactivity, the silver-doped ordered mesoporous carbons still retain an antibacterial effect, as shown by a maximum of 13.1% of inhibited area in the Halo test. The obtained results clearly showed that the silver-doped ordered mesoporous carbons exhibit both good biocompatibility and antibacterial effect with enhanced re-epithelialization, angiogenesis promotion and tissue regeneration. Discussion: These findings suggest that the exceptional properties of silver-doped ordered mesoporous carbons could be exploited in the treatment of acute and chronic wounds and that such carbon materials could be potential candidates for use in medical devices for wound healing purposes, in particular, the 10 wt% loading, as the results showed to be the most effective.

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“…In the past, metal oxide or metal hydroxide nanoparticles with angiogenic properties such as zinc oxide, cerium oxide, yttrium oxide, and europium hydroxide nanoparticles were loaded in electrospun polymeric meshes to develop angiogenic and bioactive biomaterials. Among other metal oxide nanostructures, titanium dioxide (TiO 2 ) nanomaterials have a broad spectrum of desirable properties and it has been used in wide range of applications such as catalysis, sensors, solar cells, and biomedical devices .…”

Section: Introductionmentioning

confidence: 99%

Titanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications

Augustine

Hasan

Patan

et al. 2019

Macromolecular Bioscience

Self Cite

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Proper management of nonhealing wounds is an imperative clinical challenge. For the effective healing of chronic wounds, suitable wound coverage materials with the capability to accelerate cell migration, cell proliferation, angiogenesis, and wound healing are required to protect the healing wound bed. Biodegradable polymeric meshes are utilized as effective wound coverage materials to protect the wounds from the external environment and prevent infections. Among them, electrospun biopolymeric meshes have got much attention due to their extracellular matrix mimicking morphology, ability to support cell adhesion, and cell proliferation. Herein, electrospun nanocomposite meshes based on polycaprolactone (PCL) and titanium dioxide nanorods (TNR) are developed. TNR incorporated PCL meshes are fabricated by electrospinning technique and characterized by scanning electron microscopy, energy dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy (FTIR) analysis, and X‐Ray diffraction (XRD) analysis. In vitro cell culture studies, in ovo angiogenesis assay, in vivo implantation study, and in vivo wound healing study are performed. Interestingly, obtained in vitro and in vivo results demonstrated that the presence of TNR in the PCL meshes greatly improved the cell migration, proliferation, angiogenesis, and wound healing. Owing to the above superior properties, they can be used as excellent biomaterials in wound healing and tissue regeneration applications.

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Yttrium oxide nanoparticle loaded scaffolds with enhanced cell adhesion and vascularization for tissue engineering applications

Cited by 66 publications

References 64 publications

Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates

Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Titanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications

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