Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

Hong, Sung Kyu; Nam, Jung Soo; Na, Woong; Oh, Jong Jin; Yoon, Cheol Yong; Jeong, Chang Wook; Kim, Hyun June; Byun, Seok‐Soo; Lee, Sang Eun

doi:10.1038/aja.2011.39

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…Some reports recognized advanced age as an indicator of poorer biochemical outcome [70], while others did not find any association in patients undergoing radical prostatectomy [71] or radiotherapy [72]. However, another study suggested that in high-risk younger patients, biochemical recurrence-free survival is poorer than in older patients [73]. In addition, PSA serum level was not significantly different in patients with CTC-negative and positive samples detected with the dual fluoro-EPISPOT assay.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays

Budna‐Tukan

Świerczewska

Mazel³

et al. 2019

Cancers

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The characterization of circulating tumor cells (CTCs) can lead to a promising strategy for monitoring residual or relapsing prostate cancer (PCa) after local therapy. The aim of this study was to compare three innovative technologies for CTC enumeration in 131 high-risk patients with PCa, before and after radiotherapy, combined with androgen deprivation. The CTC number was tested using the FDA-cleared CellSearch® system, the dual fluoro-EPISPOT assay that only detects functional CTCs, and the in vivo CellCollector® technology. The highest percentage of CTC-positive patients was detected with the CellCollector® (48%) and dual fluoro-EPISPOT (42%) assays, while the CellSearch® system presented the lowest rate (14%). Although the concordance among methods was only 23%, the cumulative positivity rate was 79%. A matched-pair analysis of the samples before, and after, treatment suggested a trend toward a decrease in CTC count after treatment with all methods. CTC tended to be positivity correlated with age for the fluoro-EPISPOT assay and with PSA level from the data of three assays. Combining different CTC assays improved CTC detection rates in patients with non-metastatic high-risk PCa before and after treatment. Our findings do not support the hypothesis that radiotherapy leads to cancer cell release in the circulation.

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Section: Discussionmentioning

confidence: 99%

Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays

Budna‐Tukan

Świerczewska

Mazel³

et al. 2019

Cancers

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“…Poor prognosis is reported with advanced age. [23,24] However, some studies did not find any effect at all. [25,26] In another meta-analysis study, age was not found to be a prognostic factor.…”

Section: Discussionmentioning

confidence: 93%

Factors determining biochemical recurrence in low-risk prostate cancer patients who underwent radical prostatectomy

Ün¹,

Türk²,

Koca³

et al. 2015

Turkish Journal of Urology

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Objective: This study was conducted to research the factors determining biochemical recurrence (BCR) in low-risk localized prostate cancer patients who underwent radical prostatectomy (RP). Material and methods:We retrospectively analyzed the data of 504 patients who had undergone RP between 2003 and 2013 at our clinic. One hundred and fifty-two patients who underwent RP for low-risk prostate cancer were included in the study. Results:The mean follow-up period for patients was 58.7 (21-229) months. The mean age of the patients was 63.7±7.2 years (49-79). The mean prostate specific antigen (PSA) value was 5.25±4.22 ng/mL (3.58-9.45). The BCR rate after the operation was 25% (38/152). In the univariate analysis, recurrence determining factors were shown to include extracapsular involvement (ECI) (p= 0.004), capsular invasion (CI) (p= 0.001), age (p= 0.014), and tumor size (p= 0.006). However, only CI was found to be significant in multivariate analysis (p= 0.001). Conclusion:Capsular invasion is an independent risk factor in low-risk prostate cancer patients who underwent RP for BCR.

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“…However, they did not state why younger men with seminal vesicle invasion should have unfavorable outcomes even after controlling for tumor grade and surgical margin status. Recently, Hong et al (9) determined in their cohort that younger and older patients showed no significant differences regarding pathological parameters and BCR-free survival among all subjects who underwent RP. However, in the high-risk group, younger patients (<60 years) had a lower rate of BCR-free survival after RP compared with older patients (≥60 years) even with no significant differences observed among various known prognostic parameters between these two groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of prognostic factors after radical prostatectomy in pT3b prostate cancer patients in Japanese population

Inoue

Kinoshita

Terada

et al. 2015

Jpn. J. Clin. Oncol.

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Objective: The purpose of the current study was to evaluate prognostic factors after radical prostatectomy for prostate cancer patients with seminal vesicle invasion ( pT3b) in the Japanese population. Methods: Between January 2005 and December 2011, 814 patients underwent radical prostatectomy without neoadjuvant hormonal therapy at our institutions. Among these patients, 31 were (3.8%) presented with pT3b. Kaplan-Meier method was used to determine biochemical recurrence-free, disease-specific and overall survival of patients in this group. Proportional hazards models were used to determine predictors of biochemical recurrence-free survival. Results: The median follow-up period was 60 months (range, 9-108 months). During follow-up, 23 patients (74.2%) experienced biochemical recurrence, and the overall 3-year probability of freedom from biochemical recurrence was 29%. However, only one patient died of the disease, and the 5-year overall survival was 92%. In multivariate analysis, age at the time of surgery was the only significant variable for predicting biochemical recurrence after radical prostatectomy (P = 0.0356, hazard ratio = 0.92, 95% confidence interval = 0.851-0.994). Conclusions: Patients with seminal vesicle invasion of pathological specimens after radical prostatectomy have high biochemical recurrence, but the survival was favorable especially in light of current multimodal treatment regimens. However, patients with younger age at the time of surgery, in particular, should receive multimodal treatments to improve their outcome.

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Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

Cited by 9 publications

References 28 publications

Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays

Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays

Factors determining biochemical recurrence in low-risk prostate cancer patients who underwent radical prostatectomy

Evaluation of prognostic factors after radical prostatectomy in pT3b prostate cancer patients in Japanese population

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