Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma

Abstract

Objective. The aim of this study was to examine the epidemiology, natural history, treatment pattern, and predictors of long-term survival of signet ring prostate carcinoma (SRPC) patients based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database. Methods & Results. Between 1980 and 2004, a total of 93 patients with pathologically confirmed SRPC were identified. The mean age was 70 ± 11 years old. 82.8% of the patients had poorly or undifferentiated histology grade. 13.9% patients presented with metastatic disease. The 1-, 3-, and 5-year cancer-specific survival rates were 94.6%, 89.6%, and 83.8%, respectively. Using multivariate Cox proportional hazard model, younger age (40–50 versus age >70 yrs, P = .01), advanced tumor stage (distant versus local/regional, P = .02), and earlier diagnosis year (before 1995 versus after 1995, P = .01) were predictors of worse cancer specific survival. Conclusions. Despite more aggressive cancer therapy, younger SRPC patients had a worse cancer specific survival. This information could be useful when counseling these patients and emphasizes the need for new strategies and molecular-based therapeutic approaches for younger patients with SRPC.

Brachytherapy and radical prostatectomy in patients with early prostate cancer

“…Some series show younger patients at diagnosis have more aggressive tumors. 34,35 On the other hand, other studies show that survival among younger patients was equivalent or even higher than older patients. 36,37 The median age of patients undergoing brachytherapy in this study was higher than that of the patients operated on (p=0.001), showing a current tendency of recommending this treatment only to older patients that cannot undergo surgery.…”

A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review

“…Warner et al reported an average survival time of 29 months [ 9 ]. Interestingly, Wang et al concluded that younger age is related to poor survival [ 54 ]. In the study by Saito and Iwaki, the three-year and five-year survival rates were 27.3% and 0%, respectively, while Fujita et al reported a five-year survival rate of 11.7% [ 6 , 37 ].…”