Young patients with myelofibrosis have distinct clinicomolecular features, favorable prognosis, and commonly exhibit inflammatory comorbidities

Horvat, Nathan P.; Abdallah, Enas F.; Xie, Zhuoer; Al Ali, Najla; Yun, Seongseok; Walker, Alison; Padron, Eric; Sallman, David; Chan, Onyee; Lancet, Jeffrey; Komrokji, Rami; Kuykendall, Andrew T.

doi:10.1007/s00277-023-05564-0

Ann Hematol

2023

DOI: 10.1007/s00277-023-05564-0

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Young patients with myelofibrosis have distinct clinicomolecular features, favorable prognosis, and commonly exhibit inflammatory comorbidities

Nathan P. Horvat,

Enas F. Abdallah,

Zhuoer Xie

et al.

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2024

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Cited by 2 publications

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Myeloproliferative neoplasms: young patients, current data and future considerations

Sobas,

Ianotto,

Kiladjian

et al. 2024

Ann Hematol

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Myeloproliferative neoplasms: young patients, current data and future considerations

Sobas,

Ianotto,

Kiladjian

et al. 2024

Ann Hematol

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Myeloproliferative neoplasms in the adolescent and young adult population: A comprehensive review of the literature

Goulart,

Masarova,

Mesa

et al. 2024

Br J Haematol

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SummaryMyeloproliferative neoplasms (MPN) are characterized by a clonal proliferation of myeloid lineage cells within the bone marrow. The classical BCR‐ABL negative MPNs are comprised of polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. Historically, the majority of MPNs are diagnosed in adults older than 60 years of age; however, in recent years, there has been recognition of MPNs in the adolescent and young adult (AYA) population. AYAs with MPN, typically defined as between the ages of 15 and 39 years old, may comprise up to 20% of patients diagnosed with MPN. They demonstrate unique patterns of driver mutations and thrombotic events and remain at risk for progression to more aggressive disease states. Given the likely long length of time they will live with their disease, there is a significant unmet need in identifying well‐tolerated and effective treatment options for these patients, particularly with the advent of disease modification. In this review, we provide a comprehensive overview of the clinical features, disease course and management of AYA patients with MPN and, in doing so, highlight key characteristics that distinguish them from their older counterparts.

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Young patients with myelofibrosis have distinct clinicomolecular features, favorable prognosis, and commonly exhibit inflammatory comorbidities

Cited by 2 publications

References 34 publications

Myeloproliferative neoplasms: young patients, current data and future considerations

Myeloproliferative neoplasms: young patients, current data and future considerations

Myeloproliferative neoplasms in the adolescent and young adult population: A comprehensive review of the literature

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