Young patients with cystic fibrosis demonstrate subtle alterations of the cardiovascular system

Eising, Jacobien B.; Ent, Cornelis K. van der; Teske, Arco J.; Vanderschuren, Maaike M.; Uiterwaal, Cuno S.P.M.; Meijboom, Folkert J.

doi:10.1016/j.jcf.2017.12.009

Cited by 31 publications

(34 citation statements)

References 30 publications

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“…While ventricular function appeared to be normal in TTE, both techniques gave results confirming subclinical ventricular dysfunction. 5,8,10,26 Pulmonary artery systolic pressure as measured based on the tricuspid regurgitation (TR) jet was higher in the CF patients group than in controls. an abnormal interventricular septal motion may also affect LV function.…”

Section: Discussionmentioning

confidence: 99%

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Tissue Doppler and speckle tracking echocardiography assessment of left ventricular function in children with cystic fibrosis

et al. 2020

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Background: Cystic fibrosis may lead to left ventricular (LV) dysfunction. This dysfunction can be documented by methods such as tissue Doppler echocardiographic (TDI) imaging and two-dimensional speckle tracking echocardiography (STE) in early stage. Study design: This was prospective cohort study. Methods: A total of 34 patients diagnosed with cystic fibrosis (mean age and SD 9.9 ± 4.9 years) and 37 healthy control subjects with a comparable gender and age distribution (mean age 9.8 ± 4.3) were studied. The results for the two groups were compared along with the results of published reports. Results: No significant relationship was found between the groups in terms of systolic and diastolic measurements of the interventricular septum and posterior left ventricular wall, and ejection fraction (P > .05). Myocardial performance indexes of left ventricular free wall and interventricular septum increased in the patient group compared with the controls (P < .05). As measured by STE, seven segments in the LV myocardial longitudinal strain and three segments in the LV myocardial circumferential strain showed significant reductions in patients with cystic fibrosis compared with controls (P < .05). The longitudinal global, circumferential global, and total global strain values had no significant difference between the groups (P > .05). Longitudinal strain rates and circumferential strain rates were both lower in five segments in the patient group (P < .05). Conclusions: Tissue Doppler echocardiographic imaging and STE may help identifying subclinical LV dysfunction in cystic fibrosis patients with unremarkable conventional echocardiography. They may be considered for the routine follow-up of cystic fibrosis patients.

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Section: Discussionmentioning

confidence: 99%

“…They did not find any differences in total global, mid, and apical strain values. 26 This suggested that total cardiac involvement might be related to the duration of the disease.…”

Section: Discussionmentioning

confidence: 99%

Tissue Doppler and speckle tracking echocardiography assessment of left ventricular function in children with cystic fibrosis

et al. 2020

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“…While the effects of severe lung disease on cardiovascular health in CF are well known, cardiovascular health in CF children has had less attention. A study of 33 children with CF, aged 3 to 12 years, and 33 age‐matched controls were selected from a population‐based cohort study . Measures of pulmonary function, arterial stiffness, and echocardiographic measures were compared.…”

Section: Multisystem Effects Of Cystic Fibrosismentioning

confidence: 99%

“…A study of 33 children with CF, aged 3 to 12 years, and 33 age-matched controls were selected from a population-based cohort study. 39 Thus, while specific patient-and catheter-related risk factors were identified, attention to center practices including insertion, maintenance and anticoagulation may be a target for reducing complications of the more commonly used PICCs.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

“…IQR] 1301 kcal/d vs 686; P < .0001) and proportion of energy intake (median [IQR] 44%[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] vs 31%[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]; P < .0001). Thus, while children with CF met their energy requirements and ate ample fat, this was largely due to ingestion of EDNP foods.…”

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Cystic fibrosis year in review 2018, part 2

Savant

McColley

2019

Pediatric Pulmonology

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Evaluation of increased arterial stiffness in pediatric patients with cystic fibrosis by augmentation index and pulse wave velocity analysis

Öztürk

Çonkar

Eşki

et al. 2020

Pediatric Pulmonology

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With the increase in life expectancy, cardiovascular complications of cystic fibrosis (CF) have come to the forefront. Increased arterial stiffness is a marker of increased cardiovascular risk. The aim of this study was to compare both pulse wave velocity (PWV) and augmentation index (Aix) measurements in children with CF and to compare them with healthy controls. We hypothesized that children with CF had increased arterial stiffness, although traditional risk factors for CVD were not observed. Forty‐four patients and age and sex‐matched 30 healthy controls were included in the study. Hemodynamic measurements were compared in both groups, together with traditional risk factors. Peripheral blood pressure parameters of CF and control groups were similar (P > .05). Bodyweight and BMI were significantly lower in the CF group (P < .001). Serum cholesterol, HDL, and LDL levels were significantly lower in the CF group, whereas fasting blood glucose and triglyceride levels were significantly higher than the control group (P < .05). Mean ± SD Aix was significantly higher in the CF group (33.22 ± 13.87%) compared with the control group (24.93 ± 10.58%), respectively (P < .05), while PWV was similar. No significant correlation between PWV and Aix and fasting blood glucose and lipid profile in both groups (P > .05). Children with CF have been shown to have increased arterial stiffness compared to healthy children. Although there are not many traditional risk factors, increased arterial stiffness have been demonstrated in children with CF. The effects of this process starting from childhood on the development of CVD in adulthood are not known. Therefore, further studies are needed.

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Young patients with cystic fibrosis demonstrate subtle alterations of the cardiovascular system

Abstract: Our study suggests that already at a very young age, children with cystic fibrosis show an increased arterial stiffness and some signs of diminished both right and left ventricular function.

Cited by 31 publications

References 30 publications

Tissue Doppler and speckle tracking echocardiography assessment of left ventricular function in children with cystic fibrosis

Tissue Doppler and speckle tracking echocardiography assessment of left ventricular function in children with cystic fibrosis

Cystic fibrosis year in review 2018, part 2

Evaluation of increased arterial stiffness in pediatric patients with cystic fibrosis by augmentation index and pulse wave velocity analysis

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