Young-age onset of colorectal cancer in Israel

Neufeld, David; Shpitz, Baruch; Bugaev, Nikolay; Grankin, Milla; Bernheim, Jacques; Klein, Eric A.; Ziv, Yehiel

doi:10.1007/s10151-009-0501-7

Cited by 18 publications

(15 citation statements)

References 19 publications

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“…Similar studies in Jordan and Israel showed a predominant proportion of female in patients with early-onset CRC (Al-Jaberi et al, 2003;Neufeld et al, 2009). This could be explained partly by the racial and enviromental differences.…”

Section: Discussionmentioning

confidence: 56%

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Quach¹,

Nguyen²

2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 56%

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Quach¹,

Nguyen²

2012

Asian Pacific Journal of Cancer Prevention

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“…Many studies evaluated biological behavior and risk of relapse and death in young patients with CC [3], [4], [5], [7], [8], [9], [10], [11]. Despite much research, CC in the young has not been well characterized, due to conflicting data in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…These inconsistent could be explained by: First, the current definition of young CRC patients remains controversial. Although majority of studies in the literature used the cutoff age of 40 years to denote a young patients with CC [3], [4], [5], [6], [7], some other studies used the cutoff age of 30 years [4], [15], 25 years [16] or others [17], [18], [19]. Second, young age consisted wide age range of population, which maybe an inherent characteristic of heterogeneous, different composition of young subgroup may cause different results.…”

Section: Discussionmentioning

confidence: 99%

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Pathological Features and Survival Outcomes of Young Patients with Operable Colon Cancer: Are They Homogeneous?

Zhuo

Cai

et al. 2014

PLoS ONE

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ObjectiveTo compare the pathological features and survival outcomes at different age subgroups of young patients with colon cancer.MethodsUsing Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 2,861 young patients with colon cancer diagnosed between 1988 and 2005 treated with surgery. Patients were divided into four groups: group 1 (below 25 years), group 2 (26–30 years), group 3 (31–35 years) and group 4 (36–40 years). Five-year cancer specific survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors.ResultsThere were significant different among four groups in pathological grading, histological type, AJCC stage, current standard (≥12 lymph nodes retrieval), mean number of lymph nodes examined and positive lymph nodes (p<0.001). The 5-year cause specific survival was 71.0% in group 1, 75.1% in group 2, 80.6% in group 3 and 82.5% in group 4, which had significant difference in both univariate (P = 0.002) and multivariate analysis (P = 0.041).ConclusionsYoung patients with colon cancer at age 18–40 years are essentially a heterogeneous group. Patients at age 31–35, 36–40 subgroups have more favorable clinicopathologic characteristics and better cancer specific survival than below 30 years.

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“…6 In younger patients, there seems to be a higher frequency of tumors with poor differentiation, T4 disease stage, and vascular invasion. 7,8 A recent retrospective review of nine phase III chemotherapy trials in patients with advanced CRC assessed outcomes in younger versus older patients, as defined by age < 40 or > 50 years. 9 Although younger age was associated with shorter progression-free survival (PFS), there was no difference in overall survival (OS) or response rates for younger versus older patients, and younger patients derived similar benefit from combination chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Association of Age With Survival in Patients With Metastatic Colorectal Cancer: Analysis From the ARCAD Clinical Trials Program

Lieu

Renfro

Gramont

et al. 2014

JCO

131

116

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Purpose This study addressed whether age is prognostic for overall survival (OS) or progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC). Patients and Methods A total of 20,023 patients from 24 first-line clinical trials in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were analyzed. Primary age effects and interactions with age, sex, performance status (PS), and metastatic site were modeled using Cox proportional hazards stratified by treatment arm within study. Results Of total patients, 3,051 (15%) were age ≤ 50 years. Age was prognostic for both OS (P < .001) and PFS (P < .001), with U-shaped risk (ie, highest risk was evident in youngest and oldest patients). Relative to patients of middle age, the youngest patients experienced 19% (95% CI, 7% to 33%) increased risk of death and 22% (95% CI, 10% to 35%) increased risk of progression. The oldest patients experienced 42% (95% CI, 31% to 54%) increased risk of death and 15% (95% CI, 7% to 24%) increased risk of progression or death. This relationship was more pronounced in the first year of follow-up. Age remained marginally significant for OS (P = .08) when adjusted for PS, sex, and presence of liver, lung, or peritoneal metastases, and age was significant in an adjusted model for PFS (P = .005). The age effect did not differ by site of metastatic disease, year of enrollment, type of therapy received, or biomarker mutational status. Conclusion Younger and older age are associated with poorer OS and PFS among treated patients with mCRC. Younger and older patients may represent higher-risk populations, and additional studies are warranted.

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Young-age onset of colorectal cancer in Israel

Abstract: Younger age of onset colorectal cancer in our cohort of Israeli patients is associated with higher percentage of Arab patients, mucinous cancers, female gender, and advanced stage at diagnosis.

Cited by 18 publications

References 19 publications

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Pathological Features and Survival Outcomes of Young Patients with Operable Colon Cancer: Are They Homogeneous?

Association of Age With Survival in Patients With Metastatic Colorectal Cancer: Analysis From the ARCAD Clinical Trials Program

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