Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Quach, Duc Trong; Nguyen, Oanh Thuy

doi:10.7314/apjcp.2012.13.5.1767

Cited by 26 publications

(57 citation statements)

References 17 publications

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“…We did not find any difference in the distribution of tumor (rectum vs. colon) between young and non-Young CRC groups, similar to findings from other studies looking at early onset CRC (Hav et al, 2011;Quach & Nguyen, 2012) or overall CRC cases (Cai et al, 2014). However a study from the United States reported a higher incidence of rectal cancer in persons younger than 50 years compared to older adults (Fairley et al, 2006), and several other studies have reported increasing incidence of rectal cancer among the younger population (Siegel et al, 2009;Meyer et al, 2010;Ahnen et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

“…A study from Saudi Arabia using the same definition as our study reported a rate of 20.9% (Mosli & Al-Ahwal, 2012). In South-East Asia, the rates ranged from 11.5% in Malaysia (National Cancer Registry Report 2007) to as high as 28% in Vietnam (<50 years of age) (Quach & Nguyen, 2012). However, the Vietnam study had used <50 as young CRC.…”

Section: Discussionmentioning

confidence: 52%

“…CRC is mainly a disease of the mature adult or the elderly demographic and generally considered uncommon among the younger population. However, in certain parts of the world, especially the less developed nations, Young CRC variably defined as CRC diagnosed in those ages younger than 45 to 50 years old, is not uncommon (Hav et al, 2011;Mosli et al, 2012;Quach et al, 2012). Even in the developed nations, there are reports of increasing incidence of Young CRC (Siegel et al, 2009;Meyer et al, 2010;Ahnen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)

Koh¹,

Telisinghe²,

Bickle³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is the most common gastrointestinal cancer and the incidence is increasing. CRC is more common with increasing age, but a proportion occurs in young adults, termed young CRC. This study assessed the incidence and the demographic of young CRC in Brunei Darussalam. Materials and Methods: All histologically proven CRC between 1986 and 2014 registered with the Department of Pathology cancer registry were reviewed and data extracted for analyses. Young CRC was defined as cancer in patients aged less than 45 years. The various population groups were categorized into locals (Malays, Chinese and Indigenous) and expatriates. Results: Over the study period, there were 1,126 histologically proven CRC (mean age 59.1 ± 14.7 years, Male 58.0%, Locals 91.8% and 8.2% expatriates). Young CRC accounted for 15.1% with the proportion declining over the years, from 29% (1986-1990) to 13.2% (2011-2014). The proportion of young CRC was highest among the indigenous (30.8%), followed by the expatriates (29.3%), Malays (14.3%) and lowest among the Chinese (10.8%). The mean age of young CRC was 35.9 ± 6.2; lowest among the indigenous (33.5 ± 6.7), expatriate (34.9 ± 6.0) groupd and the Malays (35.6 ± 6.5) compared to the Chinese (38.6 ± 4.6), a similar trend being observed in the non-young CRC groups. There were no difference between the genders and tumor locations (rectum or colon) between the young and the non-young CRC cases. Female young CRC was significantly younger than male (p<0.05) without any significant variation between the various population groups (p>0.05). Conclusions: Our study showed that the young CRC accounted for 15.1% of all CRC with declining trend observed over recent years. Young CRC was more common among indigenous, expatriates and Malays and least common among the Chinese. There were no differences in the gender and tumor locations.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)

Koh¹,

Telisinghe²,

Bickle³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Epidemiological surveys indicate that the incidence of colorectal cancers is much lower in the developing countries. Conversely, there have been reports that suggest a higher incidence of early onset disease in the developing world [19]. The exact cause of this difference is not known; however, it can be postulated that the higher proportion of younger patients in the underdeveloped countries can be a reason for this skewed finding [16].…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcome of Sporadic Colorectal Carcinoma in Young Patients: A Cross-Sectional Analysis from a Developing Country

et al. 2014

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Background. Early onset colorectal carcinoma (CRC) is rare and has been hypothesized to be a biologically and clinically distinct entity personifying aggressive disease and worse survival. Methods. Data for 131 patients was collected by retrospective chart review. Cox proportional hazard model was used to compute prevalence ratios and 95% confidence intervals. Results. Early onset sporadic CRC accounted for 32% of all CRC treated in the specified time period. The mean age was 33.3 ± 7.9 years and the male to female ratio was 2 : 1. Colon and rectal cancers accounted for 55% and 45% of patients, respectively. 96% of rectal carcinoma patients received appropriate therapy as opposed to 65% of colon cancers. On multivariable analysis, appropriate reception of therapy (PR 4.99; 95% CI, 1.21–20.6) and signet ring morphology (PR 2.40; 95% CI, 1.33–4.32) were significantly associated with rectal cancers as opposed to colon cancer. Kaplan-Meier analysis revealed a trend towards inferior survival for rectal carcinoma 2 years after diagnosis. Conclusion.A high prevalence of early onset CRC was noted in the study. A trend towards inferior survival was seen in patients with rectal cancer. This finding raises the possibility of rectal carcinoma being an aggressive subset of young CRC.

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“…Vietnam is one of the developing countries in Asia, and Japan is one of the developed countries. In Vietnam, CRC is the third most common cause of cancer deaths in men and fourth in women [ 2 ]. In addition, a high incidence of early-onset CRC (that occurring in patients under 50 years of age) has been reported: the ratio of early-onset CRC to all CRCs is approximately 28% [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Differences in K-rasand mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients

et al. 2014

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BackgroundThe incidence of early-onset (under 50 years of age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that in the Japanese. To clarify the differences in genetic alterations between Vietnamese and Japanese CRCs, we investigated mutations in K-ras and mitochondrial DNA (mtDNA) and high-frequency microsatellite instability (MSI-H) in the CRCs of Vietnamese and Japanese patients.MethodsWe enrolled 60 Vietnamese and 233 Japanese patients with invasive CRCs. DNA was extracted from formalin-fixed, paraffin-embedded tissue sections. K-ras mutations were examined with PCR-single-strand conformation polymorphism analysis. mtDNA mutations and MSI-H were examined with microsatellite analysis using D310 and BAT-26, respectively.ResultsK-ras mutations were examined in 60 Vietnamese and 45 Japanese CRCs. The frequency of the mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (8 of 24 [33%] vs 5 of 45 [11%], p =0.048). MSI-H was examined in 60 Vietnamese and 130 Japanese CRCs. The frequency of MSI-H in the Vietnamese CRCs was also significantly higher than that in the Japanese CRCs (6 of 27 [22%] vs 10 of 130 [8%], p =0.030). mtDNA mutations were examined in 60 Vietnamese and 138 Japanese CRCs. The frequency of mtDNA mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (19 of 44 [43%] vs 11 of 133 [9%], p <0.001). There were no significant differences in clinicopathologic characteristics, such as age, sex, tumour location, and depth, in terms of tumours with/without each genetic alteration in the CRCs of the Vietnamese and Japanese patients.ConclusionsThese results indicate that the developmental pathways of CRCs in the Vietnamese may differ from those of CRCs in the Japanese.

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Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Cited by 26 publications

References 17 publications

Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)

Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)

Clinical Features and Outcome of Sporadic Colorectal Carcinoma in Young Patients: A Cross-Sectional Analysis from a Developing Country

Differences in K-rasand mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients

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