Yorkie: the final destination of Hippo signaling

Oh, Hyangyee; Irvine, Kenneth D.

doi:10.1016/j.tcb.2010.04.005

Cited by 140 publications

(157 citation statements)

References 85 publications

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“…Since several excellent reviews have been published on these signaling pathways (for recent reviews, see Kango-Singh and Singh, 2009;L. Zhang et al, 2009;Grusche et al, 2010;Halder and Johnson, 2010;Oh and Irvine, 2010;Pan, 2010;Yi and Kissil, 2010;Zhao et al, 2010), we have not described these pathways in detail in this review. Rather, we aim to review recent advances in determining leg segment size and PVs in the leg segment, focusing on the Ds-Ft and Wts-Hpo signaling pathways.…”

Section: Fig 2 Drosophila Adult Leg Phenotypes Ofmentioning

confidence: 99%

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Bando

Mito

Nakamura

et al. 2011

Developmental Dynamics

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How limb size and shape is regulated is a long-standing question in developmental and regeneration biology. Recently, the protocadherin Dachsous-Fat (Ds-Ft) signaling pathway has been found to be essential for wing development of the fly and leg regeneration of the cricket. The Ds-Ft signaling pathway is linked to the Warts-Hippo (Wts-Hpo) signaling pathway, leading to cell proliferation. Several lines of evidence have suggested that the Wts-Hpo signaling pathway is involved in the control of organ size, and that this pathway is regulated by Ds-Ft and Merlin-Expanded, which are linked to morphogens such as decapentaplegic/bone morphogenic protein, Wingless/Wnt, and epidermal growth factor. Here we review recent progress in elucidating mechanisms controlling leg size and shape in insects and vertebrates, focusing on the Ds-Ft signaling pathway. We also introduce a working model, Ds-Ft steepness model, to explain how steepness of the Ds-Ft gradient controls leg size along the proximodistal axis. Developmental Dynamics 240:1028-1041,

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Section: Fig 2 Drosophila Adult Leg Phenotypes Ofmentioning

confidence: 99%

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Bando

Mito

Nakamura

et al. 2011

Developmental Dynamics

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“…The protocadherins Ds and Ft are linked to the unconventional myosin Dachs (D), and the FERM domain proteins Expanded (Ex) and Merlin (Mer) are linked WW domain protein Kibra (Baumgartner et al, 2010;Genevet et al, 2010;Yu et al, 2010), regulate Hippo/Salvador/ Warts (Hpo/Sav/Wts) tumor suppressor signaling, which in turn stimulates cell proliferation through the Yorkie (Yki) and Scalloped (Sd) transcriptional complex in Drosophila and mammals (for a review, see Reddy and Irvine, 2008;Oh and Irvine, 2010;Pan, 2010;Zhao et al, 2010;Halder and Johnson, 2011). The Ds/Ft signaling pathway also regulates planar cell polarity (PCP) and proximodistal tissue patterning (Reddy and Irvine, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Lft was recently shown to modulate Ds/Ft signaling in wing and leg morphogenesis by its interactions with the intracellular domains of both Ds and Ft (Mao et al, 2009), for review, see (Oh and Irvine, 2010;Pan, 2010;Zhao et al, 2010). Vertebrate homologues of Lft are known as Lix1 in chicken and mouse (Swindell et al, 2001;Moeller et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Lowfat, a mammalian Lix1 homologue, regulates leg size and growth under the Dachsous/Fat signaling pathway during tissue regeneration†

Bando

Hamada

Kurita

et al. 2011

Developmental Dynamics

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In the cricket Gryllus bimaculatus, missing distal parts of amputated legs are regenerated from blastemas based on positional information. The Dachsous/Fat (Ds/Ft) signaling pathway regulates blastema cell proliferation and positional information along the longitudinal axis during leg regeneration. Herein, we show that the Gryllus homologue of Lowfat (Gb'Lft), which modulates Ds/Ft signaling in Drosophila, is involved in leg regeneration. Gb'lft is expressed in regenerating legs, and RNAi against Gb'lft (Gb'lft RNAi ) suppressed blastema cell hyperproliferation caused by Gb'ft RNAi or Gb'ds RNAi but enhanced that caused by Gb'kibra RNAi or Gb'warts RNAi . In Gb'lft RNAi nymphs, missing parts of amputated legs were regenerated, but the length of the regenerated legs was shortened depending on the position of the amputation. Both normal and reversed intercalary regeneration occurred in Gb'lft RNAi nymphs, suggesting that Gb'Lft is involved in blastema cell proliferation and longitudinal leg regeneration under the Ds/Ft signaling pathway, but it is not required for intercalary regeneration.

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“…63 Yki has been classified as an oncogene, as it promotes proliferation and growth under normal conditions, and thus inhibits apoptosis. 15 Consequently, inactivation of the core kinase cascade causes tissue overgrowth because of Yki derepression. If the caffeine-dependent ablation of eye tissue we observed in hpo-or wts-RNAi animals were indeed a consequence of Yki activity, then one would expect Yki overexpression (ey4yki-cDNA) to produce a comparable eye phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…9 When Hippo signaling is inactive, Yki localizes to the nucleus where it forms complexes with transcription factors such as Scalloped, [10][11][12] Homothorax 13 or Mad 14 to activate the expression of target genes that promote cell growth, survival and proliferation. 15 Yki therefore acts as a growth promoter, whereas Hpo, Wts, Mats and Sav are considered tumor suppressors.…”

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confidence: 99%

The Hippo pathway promotes cell survival in response to chemical stress

Cara

Maile²,

Parsons

et al. 2015

Cell Death Differ

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Cellular stress defense mechanisms have evolved to maintain homeostasis in response to a broad variety of environmental challenges. Stress signaling pathways activate multiple cellular programs that range from the activation of survival pathways to the initiation of cell death when cells are damaged beyond repair. To identify novel players acting in stress response pathways, we conducted a cell culture RNA interference (RNAi) screen using caffeine as a xenobiotic stress-inducing agent, as this compound is a well-established inducer of detoxification response pathways. Specifically, we examined how caffeine affects cell survival when Drosophila kinases and phosphatases were depleted via RNAi. Using this approach, we identified and validated 10 kinases and 4 phosphatases that are essential for cell survival under caffeine-induced stress both in cell culture and living flies. Remarkably, our screen yielded an enrichment of Hippo pathway components, indicating that this pathway regulates cellular stress responses. Indeed, we show that the Hippo pathway acts as a potent repressor of stress-induced cell death. Further, we demonstrate that Hippo activation is necessary to inhibit a pro-apoptotic program triggered by the interaction of the transcriptional co-activator Yki with the transcription factor p53 in response to a range of stress stimuli. Our in vitro and in vivo loss-of-function data therefore implicate Hippo signaling in the transduction of cellular survival signals in response to chemical stress. Throughout their lives, organisms are exposed to a wide range of harmful substances. These compounds, often referred to as xenobiotics, may enter the body through direct contact, inhalation or ingestion, and can originate from many sources including pharmaceuticals, pesticides, plant toxins and pollutants. The ubiquitous and varied nature of xenobiotic pressure is reflected in the complexity of conserved cellular defense mechanisms that respond to these chemical compounds, and metazoans have thus developed a range of pathways that activate survival responses or trigger programmed cell death to eliminate damaged cells. 1 Xenobiotic pathways control the expression and activation of heat shock proteins, oxidative stress components, DNA repair enzymes, hypoxia response factors and several groups of xenobiotic-metabolizing enzymes. In eukaryotes, environmental challenges that activate stress response programs are relayed through a complex signaling cascade. Some stress pathways respond to very specific compounds, whereas others, such as those depending on Mitogen-activated protein kinases, propagate stress signals from a broad spectrum of stimuli. 1-3 Despite the importance that stress response pathways play in pharmacology and toxicology, we still have a relatively poor understanding of the complex networks that launch these cellular defense systems.We performed a quantitative cell-culture RNA interference (RNAi) assay of Drosophila kinases and phosphatases to identify key regulators of stress response pathways that reac...

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Yorkie: the final destination of Hippo signaling

Cited by 140 publications

References 85 publications

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Lowfat, a mammalian Lix1 homologue, regulates leg size and growth under the Dachsous/Fat signaling pathway during tissue regeneration†

The Hippo pathway promotes cell survival in response to chemical stress

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