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Sewak, Sanjeev; Muggia, Franco M.; Zagzag, David

doi:10.1023/a:1016039024196

Cited by 16 publications

(8 citation statements)

References 14 publications

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“…Of 35 papers on brain metastases from endometrial carcinoma published in the literature, 19 documented one patient each [16, 19, 21, 25–29, 32, 38, 40, 43–45, 48, 49, 52, 54, 55], seven: 2 patients each [33–35, 37, 39, 42, 47], two: 3 patients each [30, 50], one: 6 patients [53], one: 8 patients [46], two: 10 patients each [36, 41], two: 11 patients [24, 31], and one: 20 patients [51]. Age at diagnosis of brain metastases from endometrial carcinoma ranged from 40 to 83 years with a median of 60 years (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Brain Metastases from Endometrial Carcinoma

Piura

2012

ISRN Oncology

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This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy.

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Section: Introductionmentioning

confidence: 99%

Brain Metastases from Endometrial Carcinoma

Piura

2012

ISRN Oncology

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“…However, as long-term survival from gynecologic cancer improves with better chemotherapy and therapeutic modalities, there has been a corresponding increase in the incidence of diagnosed brain metastases from these diseases. 1 , 2 The observed increase can be attributed better treatment regimens, improvement in survival, and better imaging modalities. 3 – 6 …”

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confidence: 99%

Factors Predictive of Improved Survival in Patients With Brain Metastases From Gynecologic Cancer: A Single Institution Retrospective Study of 47 Cases and Review of the Literature

Gressel

Lundsberg

Altwerger

et al. 2015

Int J Gynecol Cancer

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ObjectiveThe reported incidence of brain metastasis from epithelial ovarian cancer (EOC), endometrial cancer (EC), and cervical cancer (CC) is exceedingly rare. As the long-term survival for patients with gynecologic cancer increases, there has been a corresponding increase in the number of diagnosed intracranial metastases. We seek to report our experience with managing brain metastatic disease (BMD) in patients with gynecologic cancer.MethodsA retrospective review of all patients with EOC, EC, and CC at our institution revealed 47 patients with concurrent BMD between 2000 and 2013. Demographic data, risk factors, treatment modalities, progression-free data, and overall survival data were collected.ResultsMedian survival time in patients with brain metastasis from EOC, EC, and CC was 9.0, 4.5, and 3.0 months, respectively. Two-year overall survival rates were 31.6%, 13.6%, and 0%, respectively. Patients received surgery, radiation therapy alone, palliative care, or radiation plus surgery. Radiation combined with surgical resection resulted in a significant hazards ratio of 0.36 (95% confidence interval, 0.15–0.86), compared with radiation alone.ConclusionsOur report provides a large single-institution experience of brain metastases from gynecologic cancer. Patients with BMD have poor prognoses; however, treatment with multimodal therapy including surgical resection and radiation may prolong overall survival.

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“…In a Gynaecologic Oncology Group, phase II study investigating the use of pegylated liposomal doxorubicin in 42 patients with recurrent previously treated metastatic endometrial cancer, four patients manifested new brain metastases (two in the cerebellum). Individual case reports describe one case with metastases to cerebellum and one to the pituitary gland [9].…”

Section: Discussionmentioning

confidence: 99%

Endometrial adenocarcinoma presenting as a suprasellar mass: lessons to be learned

Granina¹,

Fehniger²,

Kondziolka³

et al. 2020

ecancer

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A 66-year-old woman with a history of stage IA mixed endometrioid and serous endometrial cancer presented to our centre with 2 weeks of worsening headaches nearly 4 years after her initial surgery. At admission, she manifested bitemporal hemianopsia, difficulty walking and clinical and laboratory findings of panhypopituitarism, including diabetes insipidus. Magnetic resonance imaging of the brain revealed a 2.7 cm sellar/suprasellar mass compressing the optic chiasm and infiltrating the pituitary stalk. Computerised tomography documented mediastinal, lung, adrenal and liver involvement, including a 2.5 cm palpable left supraclavicular node that on excisional biopsy demonstrated metastatic endometrial adenocarcinoma. Due to the advanced stage of her cancer as well as the presence of multiple metastases, including lung and hepatic metastases causing postobstructive pneumonia and coagulopathy, the sellar/suprasellar mass was treated with fractionated radiosurgery rather than surgical excision.

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Cited by 16 publications

References 14 publications

Brain Metastases from Endometrial Carcinoma

Brain Metastases from Endometrial Carcinoma

Factors Predictive of Improved Survival in Patients With Brain Metastases From Gynecologic Cancer: A Single Institution Retrospective Study of 47 Cases and Review of the Literature

Endometrial adenocarcinoma presenting as a suprasellar mass: lessons to be learned

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