Brain Metastases from Endometrial Carcinoma

Abstract

This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy.

Is Neurosurgery With Adjuvant Radiotherapy an Effective Treatment Modality in Isolated Brain Involvement From Endometrial Cancer?: From Case Report to Analysis

“…1,2,6,7 Chemotherapy, surgical resection, whole-brain radiotherapy (WBRT), stereotactic radiosurgery, or combinations of these therapeutic modalities are the options in case of a metastatic brain tumor. 2,8,9 Surgery is the mainstay of treatment in patients with brain involvement regardless of tumor origin, especially for a single lesion. 10 Whole-brain radiotherapy is the standard therapy for unresectable tumors or resection cavity.…”

“…1Y3 Many authors were all of one mind about prognosis and survival that were affected unfavorably from concurrent extracranial dissemination. 2,8,12 Because of improved survival of patients with EC and advancing neuroimaging technologies, encountering isolated brain recurrences (BRs) is becoming more frequent. The incidence of isolated brain involvement among the patients with BL from EC was 21% to 23%.…”

Brain Metastases in a Patient with Ovarian Cancer

“…[10], while in 2014, Pakneshan et al reported 591 cases between 1978 and 2013. [11] Piura and Piura determined the incidence of brain metastases from ovarian cancer to be 1.2% [10], which was twice the incidence associated with cervical [12] or endometrial cancer [13]. Pakneshan et al reported that the incidence among the various studies ranged from 0.49 to 11.4%, with an average of 2.55% [11].…”

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“…According to the literature, the patient had bone and cerebral metastases when the disease was very disseminated [5]. Radiotherapy is a successful and time efficient method by wich to palliate pain and/or prevent the morbidity of bone metastases.…”