2007
DOI: 10.1007/s10735-007-9100-y
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YKL-40 protein expression in normal adult human tissues – an immunohistochemical study

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Cited by 12 publications
(18 citation statements)
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“…PC is characterized by scattered cancer cells embedded in a fibrotic desmoplastic stroma [40]. Neither YKL-40 nor IL-6 is a cancer-specific biomarker, and both are produced by cancer cells and inflammatory cells and are biomarkers of inflammation and tissue remodeling [3], [5], [6], [14], [15], [41][43]. Elevated plasma YKL-40 is found in a subset of patients with cancer and patients with non-malignant diseases characterized by inflammation and/or tissue remodeling [5].…”
Section: Discussionmentioning
confidence: 99%
“…PC is characterized by scattered cancer cells embedded in a fibrotic desmoplastic stroma [40]. Neither YKL-40 nor IL-6 is a cancer-specific biomarker, and both are produced by cancer cells and inflammatory cells and are biomarkers of inflammation and tissue remodeling [3], [5], [6], [14], [15], [41][43]. Elevated plasma YKL-40 is found in a subset of patients with cancer and patients with non-malignant diseases characterized by inflammation and/or tissue remodeling [5].…”
Section: Discussionmentioning
confidence: 99%
“…mast cells, macrophages, neutrophil granulocytes, chondrocytes and vascular smooth muscle cells, and may be in hepatic stellate cells). 25,38,39 YKL-40 is expressed by macrophages in the inflamed synovial membrane of patients with rheumatoid arthritis, and high serum YKL-40 is related to progression in joint destruction. 15 In patients with rheumatoid arthritis and osteoarthritis, the number of YKL-40-positive cells is related to the degree of synovitis.…”
Section: Discussionmentioning
confidence: 99%
“…He concluded that all cells with a functioning nucleus appear to be capable of expressing YKL-40 in the cytoplasm with various intensity levels dependent on cellular activity [8]. Compared with healthy subjects, elevated YKL-40 values were reported in patients with primary or metastatic solid cancer of the breast, colon-rectum, brain (glioblas-toma), kidney, lung, skin (melanoma), pancreas, and prostate.…”
Section: Discussionmentioning
confidence: 99%