YKL-40 protein expression in normal adult human tissues – an immunohistochemical study

Diagnostic and Prognostic Impact of Circulating YKL-40, IL-6, and CA 19.9 in Patients with Pancreatic Cancer

“…PC is characterized by scattered cancer cells embedded in a fibrotic desmoplastic stroma [40]. Neither YKL-40 nor IL-6 is a cancer-specific biomarker, and both are produced by cancer cells and inflammatory cells and are biomarkers of inflammation and tissue remodeling [3], [5], [6], [14], [15], [41]–[43]. Elevated plasma YKL-40 is found in a subset of patients with cancer and patients with non-malignant diseases characterized by inflammation and/or tissue remodeling [5].…”

YKL‐40 and mast cells are associated with detrusor fibrosis in patients diagnosed with bladder pain syndrome/interstitial cystitis according to the 2008 criteria of the European Society for the Study of Interstitial Cystitis

“…mast cells, macrophages, neutrophil granulocytes, chondrocytes and vascular smooth muscle cells, and may be in hepatic stellate cells). 25,38,39 YKL-40 is expressed by macrophages in the inflamed synovial membrane of patients with rheumatoid arthritis, and high serum YKL-40 is related to progression in joint destruction. 15 In patients with rheumatoid arthritis and osteoarthritis, the number of YKL-40-positive cells is related to the degree of synovitis.…”

Immunohistochemical expression of YKL-40 in peritoneal endometriosis

“…He concluded that all cells with a functioning nucleus appear to be capable of expressing YKL-40 in the cytoplasm with various intensity levels dependent on cellular activity [8]. Compared with healthy subjects, elevated YKL-40 values were reported in patients with primary or metastatic solid cancer of the breast, colon-rectum, brain (glioblas-toma), kidney, lung, skin (melanoma), pancreas, and prostate.…”