Immunohistochemical expression of YKL-40 in peritoneal endometriosis

Kim, Pan Jo; Hong, Dae Gy; Park, Ji Young; Cho, Young Lae; Park, Il Soo; Lee, Yoon Soon

doi:10.3109/09513590903184068

Cited by 5 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another parameter analysed in this study was YKL-40, secreted by neutrophils and macrophages in inflamed tissues, which makes it a biomarker of inflammation. However, the first available publication describing studies on YKL-40 concentration in endometriosis was published in 2010, and there is still only sparse information on this subject [43]. Tuten et al [44] reported significantly higher serum YKL-40 concentrations in patients with endometriosis in comparison to the control group, which is in accordance with the observations of this study.…”

Section: Discussionsupporting

confidence: 87%

Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis

Kokot

Piwowar

Jędryka

et al. 2021

IJMS

View full text Add to dashboard Cite

Endometriosis is a gynecological disease, the pathogenesis of which seems to be directly associated with inflammatory processes. Serum concentrations of IL-1β, IL-6, hs-CRP, IgG, YKL 40 and PRL, in comparison to the well-known CA 125 levels, were studied with the aim of identifying an additional noninvasive inflammatory marker or set of markers characteristic for endometriosis. The study group included 43 women with endometriosis (E), 35 women with benign gynecological disorders but without endometriosis (NE, non-endometriosis) as a comparative group, and a control group consisting of 18 healthy subjects (C). The serum concentrations of IL-1β, IL-6, hs-CRP, YKL-40, PRL and CA 125 were significantly higher in the E group (median values: 0.41 pg/mL, 2.42 pg/mL, 2.33 mg/L, 79.30 ng/mL, 21.88 ng/mL and 68.00 U/mL, respectively) than in the control group (median values: 0.21 pg/mL, 0.98 pg/mL, 0.52 mg/L, 49.77 ng/mL, 12.08 ng/mL and 12.20 U/mL respectively), with the significance of p = 0.011, p < 0.001, p = 0.028, p = 0.005, p < 0.001 and p < 0.001, respectively. The IgG concentrations were significantly lower in the endometriosis group (median value: 1061.21 mg/dL) as compared to healthy women (median value: 1210.50 mg/dL; p = 0.025). Significant differences in concentrations of IL-6 (p = 0.040), hs-CRP (p = 0.007) and CA 125 (p < 0.001) were observed in stage III vs. stage IV of endometriosis. Significantly higher concentrations of IL-6 (p = 0.010), hs-CRP (p = 0.037) and PRL (p < 0.001) were observed in the NE group vs. the control group. Only CA 125 concentrations were significantly higher in endometriosis patients as compared to the non-endometriosis group (p < 0.001). The proposed panel of inflammatory markers, especially IL-6, PRL and CA 125, may become a useful tool to identify women with advanced endometriosis who could qualify for treatment.

show abstract

Section: Discussionsupporting

confidence: 87%

Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis

Kokot

Piwowar

Jędryka

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…YKL-40 (alternatively called HCgp39 or CHI3L1) is observed in elevated levels for patients with severe asthma [91], cardiovascular disease and diabetes [92], cancer [93], peritoneal endometriosis [94], morbid obesity [95], osteoarthritis [96], and liver fibrosis [97]. The other chi-lectin YKL-39 (or CHI3L2) has been observed up-regulated in osteoarthritic chondrocytes [98] and osteoarthritic cartilage [99].…”

Section: Enzymes Acting On Chitin and Chitosanmentioning

confidence: 99%

Production of Chitooligosaccharides and Their Potential Applications in Medicine

et al. 2010

View full text Add to dashboard Cite

Chitooligosaccharides (CHOS) are homo- or heterooligomers of N-acetylglucosamine and D-glucosamine. CHOS can be produced using chitin or chitosan as a starting material, using enzymatic conversions, chemical methods or combinations thereof. Production of well-defined CHOS-mixtures, or even pure CHOS, is of great interest since these oligosaccharides are thought to have several interesting bioactivities. Understanding the mechanisms underlying these bioactivities is of major importance. However, so far in-depth knowledge on the mode-of-action of CHOS is scarce, one major reason being that most published studies are done with badly characterized heterogeneous mixtures of CHOS. Production of CHOS that are well-defined in terms of length, degree of N-acetylation, and sequence is not straightforward. Here we provide an overview of techniques that may be used to produce and characterize reasonably well-defined CHOS fractions. We also present possible medical applications of CHOS, including tumor growth inhibition and inhibition of TH2-induced inflammation in asthma, as well as use as a bone-strengthener in osteoporosis, a vector for gene delivery, an antibacterial agent, an antifungal agent, an anti-malaria agent, or a hemostatic agent in wound-dressings. By using well-defined CHOS-mixtures it will become possible to obtain a better understanding of the mechanisms underlying these bioactivities.

show abstract

State-of-the-art and future perspectives in infertility diagnosis: Conventional versus nanotechnology-based assays

Andone,

Handrea-Dragan,

Botiz

et al. 2023

Nanomedicine: Nanotechnology, Biology and Medicine

View full text Add to dashboard Cite

Immunohistochemical expression of YKL-40 in peritoneal endometriosis

Abstract: YKL-40 is related to severity of peritoneal endometriosis. However why a different expression level of immunohistochemical staining should occur is not known and needs further investigation.

Cited by 5 publications

References 22 publications

Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis

Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis

Production of Chitooligosaccharides and Their Potential Applications in Medicine

State-of-the-art and future perspectives in infertility diagnosis: Conventional versus nanotechnology-based assays

Contact Info

Product

Resources

About