2017
DOI: 10.5582/bst.2017.01259
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Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research

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Cited by 7 publications
(6 citation statements)
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“…Yin-yang effects of repressive versus repressive or adhesive versus repulsive nature have been described during neural development and disease [ 27 , 28 ]. With respect to cancer biology, yin-yang effects have been described inter-alia for the action of signalling molecules and transcription factors [ 29 ]. In 1991, a transcription factor ubiquitously expressed in mammalian cells was named yin-yang 1, according to its context-dependent activation or repression of transcription [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Yin-yang effects of repressive versus repressive or adhesive versus repulsive nature have been described during neural development and disease [ 27 , 28 ]. With respect to cancer biology, yin-yang effects have been described inter-alia for the action of signalling molecules and transcription factors [ 29 ]. In 1991, a transcription factor ubiquitously expressed in mammalian cells was named yin-yang 1, according to its context-dependent activation or repression of transcription [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…The association between IL-17-producing Treg and IL-10-producing Th17 and "Yin-Yang" Current discussions regarding the relationship between Yin and Yang and the immune system revolve around their opposing attributes, drawing parallels with the mutually inhibitory functions of immune cells and molecules [230][231][232]. In light of the immune functions of Treg and Th17, Treg, which secrete IL-10 to inhibit immune reactions, are linked to Yin, while Th17, which secrete IL-17 to promote immune reactions, are associated with Yang.…”
Section: The Chinese "Yin-yang" Theory and Immune Systemmentioning
confidence: 99%
“…Tumor infiltrating leukocytes, particularly monocytes, myeloid derived suppressor cells (MDSCs) and neutrophils create a tumor microenvironment (TME) that is inhospitable to effector cells such as CD4 and CD8 T cells and NK cells (4)(5)(6)(7)(8). Myeloid lineage cells such as dendritic cells (DCs), tumor associated macrophages (TAMs) and MDSCs can serve a dichotomous role within the TME, though in general they are largely immune suppressive (9)(10)(11)(12). These myeloid cells can promote tumor growth by exerting immune suppressive pressure, including secreted cytokines and growth factors promoting angiogenesis, direct cellular signaling or recruitment of Tregs and other immune suppressive cells such as TAMs, MDSCs, tumor associated neutrophils (TANs) and DCs (13).…”
Section: Introductionmentioning
confidence: 99%
“…The net outcome of the dynamic interplay in the TME is determined in part by secreted factors and cell signaling from tumor and stromal cells and by the resident immune cells within the TME, which perpetuate either a suppressive or stimulatory immune landscape ( 1 , 4 , 10 , 12 ). Targeting of myeloid immune suppressor cells to reduce or eliminate their immune suppressive impacts on adaptive immunity can turn the tide between cancer and the host’s immunity, thereby increasing tumor control and improving the efficacy of other treatments.…”
Section: Introductionmentioning
confidence: 99%