Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research

Wei, Shuyong

doi:10.5582/bst.2017.01259

Cited by 7 publications

(6 citation statements)

References 64 publications

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“…Yin-yang effects of repressive versus repressive or adhesive versus repulsive nature have been described during neural development and disease [ 27 , 28 ]. With respect to cancer biology, yin-yang effects have been described inter-alia for the action of signalling molecules and transcription factors [ 29 ]. In 1991, a transcription factor ubiquitously expressed in mammalian cells was named yin-yang 1, according to its context-dependent activation or repression of transcription [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Presence of Yin-Yang Effects in the Migration Pattern of Staurosporine-Treated Single versus Collective Breast Carcinoma Cells

Meyer

Kraus

Glassmann

et al. 2021

IJMS

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Background: Staurosporine-dependent single and collective cell migration patterns of breast carcinoma cells MDA-MB-231, MCF-7, and SK-BR-3 were analysed to characterise the presence of drug-dependent migration promoting and inhibiting yin-yang effects. Methods: Migration patterns of various breast cancer cells after staurosporine treatment were investigated using Western blot, cell toxicity assays, single and collective cell migration assays, and video time-lapse. Statistical analyses were performed with Kruskal–Wallis and Fligner–Killeen tests. Results: Application of staurosporine induced the migration of single MCF-7 cells but inhibited collective cell migration. With the exception of low-density SK-BR-3 cells, staurosporine induced the generation of immobile flattened giant cells. Video time-lapse analysis revealed that within the borderline of cell collectives, staurosporine reduced the velocity of individual MDA-MB-231 and SK-BR-3, but not of MCF-7 cells. In individual MCF-7 cells, mainly the directionality of migration became disturbed, which led to an increased migration rate parallel to the borderline, and hereby to an inhibition of the migration of the cell collective as a total. Moreover, the application of staurosporine led to a transient activation of ERK1/2 in all cell lines. Conclusion: Dependent on the context (single versus collective cells), a drug may induce opposite effects in the same cell line.

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Section: Discussionmentioning

confidence: 99%

The Presence of Yin-Yang Effects in the Migration Pattern of Staurosporine-Treated Single versus Collective Breast Carcinoma Cells

Meyer

Kraus

Glassmann

et al. 2021

IJMS

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“…The association between IL-17-producing Treg and IL-10-producing Th17 and "Yin-Yang" Current discussions regarding the relationship between Yin and Yang and the immune system revolve around their opposing attributes, drawing parallels with the mutually inhibitory functions of immune cells and molecules [230][231][232]. In light of the immune functions of Treg and Th17, Treg, which secrete IL-10 to inhibit immune reactions, are linked to Yin, while Th17, which secrete IL-17 to promote immune reactions, are associated with Yang.…”

Section: The Chinese "Yin-yang" Theory and Immune Systemmentioning

confidence: 99%

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Cui,

Wang,

et al. 2024

Cell Commun Signal

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The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount importance in ensuring internal homeostasis and disease progression. Recently, novel subsets of Treg and Th17, namely IL-17-producing Treg and IL-10-producing Th17 have been identified. IL-17-producing Treg and IL-10-producing Th17 are widely considered as the intermediates during Treg/Th17 transformation. These “bi-functional” cells exhibit plasticity and have been demonstrated with important roles in multiple physiological functions and disease processes. Yin and Yang represent opposing aspects of phenomena according to the ancient Chinese philosophy “Yin-Yang” theory. Furthermore, Yin can transform into Yang, and vice versa, under specific conditions. This theory has been widely used to describe the contrasting functions of immune cells and molecules. Therefore, immune-activating populations (Th17, M1 macrophage, etc.) and immune overreaction (inflammation, autoimmunity) can be considered Yang, while immunosuppressive populations (Treg, M2 macrophage, etc.) and immunosuppression (tumor, immunodeficiency) can be considered Yin. However, another important connotation of “Yin-Yang” theory, the conversion between Yin and Yang, has been rarely documented in immune studies. The discovery of IL-17-producing Treg and IL-10-producing Th17 enriches the meaning of “Yin-Yang” theory and further promotes the relationship between ancient “Yin-Yang” theory and modern immunology. Besides, illustrating the functions of IL-17-producing Treg and IL-10-producing Th17 and mechanisms governing their differentiation provides valuable insights into the mechanisms underlying the dynamically changing statement of immune statement in health and diseases.

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“…Tumor infiltrating leukocytes, particularly monocytes, myeloid derived suppressor cells (MDSCs) and neutrophils create a tumor microenvironment (TME) that is inhospitable to effector cells such as CD4 and CD8 T cells and NK cells (4)(5)(6)(7)(8). Myeloid lineage cells such as dendritic cells (DCs), tumor associated macrophages (TAMs) and MDSCs can serve a dichotomous role within the TME, though in general they are largely immune suppressive (9)(10)(11)(12). These myeloid cells can promote tumor growth by exerting immune suppressive pressure, including secreted cytokines and growth factors promoting angiogenesis, direct cellular signaling or recruitment of Tregs and other immune suppressive cells such as TAMs, MDSCs, tumor associated neutrophils (TANs) and DCs (13).…”

Section: Introductionmentioning

confidence: 99%

“…The net outcome of the dynamic interplay in the TME is determined in part by secreted factors and cell signaling from tumor and stromal cells and by the resident immune cells within the TME, which perpetuate either a suppressive or stimulatory immune landscape ( 1 , 4 , 10 , 12 ). Targeting of myeloid immune suppressor cells to reduce or eliminate their immune suppressive impacts on adaptive immunity can turn the tide between cancer and the host’s immunity, thereby increasing tumor control and improving the efficacy of other treatments.…”

Section: Introductionmentioning

confidence: 99%

Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment

2023

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Cancer progression and metastasis due to tumor immune evasion and drug resistance is strongly associated with immune suppressive cellular responses, particularly in the case of metastatic tumors. The myeloid cell component plays a key role within the tumor microenvironment (TME) and disrupts both adaptive and innate immune cell responses leading to loss of tumor control. Therefore, strategies to eliminate or modulate the myeloid cell compartment of the TME are increasingly attractive to non-specifically increase anti-tumoral immunity and enhance existing immunotherapies. This review covers current strategies targeting myeloid suppressor cells in the TME to enhance anti-tumoral immunity, including strategies that target chemokine receptors to deplete selected immune suppressive myeloid cells and relieve the inhibition imposed on the effector arms of adaptive immunity. Remodeling the TME can in turn improve the activity of other immunotherapies such as checkpoint blockade and adoptive T cell therapies in immunologically “cold” tumors. When possible, in this review, we have provided evidence and outcomes from recent or current clinical trials evaluating the effectiveness of the specific strategies used to target myeloid cells in the TME. The review seeks to provide a broad overview of how myeloid cell targeting can become a key foundational approach to an overall strategy for improving tumor responses to immunotherapy.

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Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research

Cited by 7 publications

References 64 publications

The Presence of Yin-Yang Effects in the Migration Pattern of Staurosporine-Treated Single versus Collective Breast Carcinoma Cells

The Presence of Yin-Yang Effects in the Migration Pattern of Staurosporine-Treated Single versus Collective Breast Carcinoma Cells

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment

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