Most species of Cucurbitaceae respond favorably to irrigation, especially when combined with fertilizers. The effect of drip irrigation combined with nitrogen fertigation in melon grown on a very light soil in Central Poland, during 2013–2015, was evaluated. The field experimental design was a split-plot with four replications. Two factors were studied: (1) irrigation treatments applied in two combinations—drip irrigation + broadcast nitrogen fertilization (control), and drip irrigation + fertigation with nitrogen; (2) two cultivars—Melba and Seledyn. The total marketable yield of fruits, weight of a single fruit, and the concentration of dry matter, total sugars, monosaccharides, ascorbic acid, total carotenoids, and polyphenols were evaluated. Tested factors presented a significant effect both on the yield and nutritive value characteristics. Drip irrigation combined with nitrogen fertigation, comparing to the control, notably improved yields and nutritional value of fruits. Seledyn produced better yields than Melba. This study shows that on very light soil, with low water and nutrient retention capacity, melon should be drip-irrigated and nitrogen-fertigated to obtain the best cultivation results.